Signaling by FGFR1 (Homo sapiens)

From WikiPathways

Revision as of 11:20, 1 November 2018 by ReactomeTeam (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
16, 28, 39, 45, 88...608, 24, 35, 11120, 6987, 102, 132, 14519, 69, 98, 1172, 61, 123, 129, 15387, 102, 132, 14564, 832, 100, 123, 129, 153...30, 52, 79, 85, 1313, 102, 12756, 15069, 97, 9831, 48, 912, 61, 123, 129, 1535, 14, 22, 16213, 21, 33, 36, 53...11, 68, 76127, 13255, 62, 104, 14652, 79, 85, 131, 1376015, 52, 79, 85781131, 42, 6887, 102, 14514, 19, 81, 983, 102, 12781, 117, 139102, 12730, 9378, 16329, 73, 74, 102, 110...78, 8698, 11790, 1039310, 18, 92, 1205, 14, 22, 10513, 36, 53, 80, 115...9, 13, 29, 46, 66...11214, 22, 1051, 6827, 29, 46, 108, 127...27, 47, 50, 75, 102...7, 43, 122, 136, 141...20, 109, 116, 14810, 18, 92, 12046, 87, 102, 127, 14540, 42, 6419, 392, 61, 123, 129, 153493, 102, 1276062, 104, 13919, 392, 61, 123, 129, 1536712, 26, 70, 72, 82...6, 23, 25, 71, 84...13, 8759, 9366, 13419, 3919, 22, 32, 69, 9729, 38, 110, 1666076, 1126763, 98, 14826, 72, 82, 96, 118...43cytosolFGF5-1 FGFRL1 ADPKL-1 FGF2(10-155) ADPFGF9 Activated FGFR1mutants andfusions:PLCG1activatedFGFR1:p-4Y-PLCG1FGF5-1 FGF3 FGF4 MYO18A-p-2Y-FGFR1 fusion FGF2(10-155) GRB2:GAB2FGF5-1 PI(3,4,5)P3 p-8Y-FGFR1b ADPp-8Y-FGFR1c p-Y177-BCR-pY-FGFR1mutant:GRB2:p-GAB2:PIK3R1p-6Y-FRS2 FLRT1,2,3KL-1 FGF5-1 FGF3 GalNAc-T178-FGF23(25-251) HRAS ActivatedFGFR1:p-8T-FRS2HRAS GRB2-1 FGF17-1 FGF23(25-251) ADPFGF8-1 UBA52(1-76) GalNAc-T178-FGF23(25-251) UBC(457-532) GalNAc-T178-FGF23(25-251) GalNAc-T178-FGF23(25-251) FGF3 p-Y55,Y227-SPRY2 UBC(153-228) FGF2(10-155) FGF22 FGF22 UBA52(1-76) TRIM24-p-2Y-FGFR1 fusion FGF8-1 LRRFIP1-p-2Y-FGFR1 fusion FGF23(25-251) FGF23(25-251) FGF22 FGF17-1 Activated FGFR1mutant dimers withenhanced kinaseactivityFGF3 FGF17-1 FGF4 FGF22 PIK3R1 FGF9 ATPPIK3R1 UBC(609-684) PIP3 activates AKTsignalingHS FGF9 PIK3R1SPRED2 STAT5A,STAT5BUBC(229-304) FGF3 FGF5-1 FGFR1c homodimerbound to FGFFGFR1 K656E UBC(1-76) FGF5-1 p-6Y-FRS2 KL-1 FGF17-1 KL-2 HS FGF8-1 cytosolic activated FGFR1 fusion mutants FGF22 FGF20 SPRY2 FGF23(25-251) FGF1 FGF9 UBC(457-532) p-8Y-FGFR1b FGF5-1 FGF10 FGF17-1 SHC1-2,SHC1-3UBC(1-76) FGFR1b homodimerbound to FGFFGF3 FGF10 PPP2CB FGF17-1 p-8Y-FGFR1c UBB(77-152) FGF5-1 Activated FGFR1 mutants KL-2 FGF10 PPP2CB FGF23(25-251) FGF2(10-155) p-Y371-CBL FGFR1b SHC1-2 p-S111,S120-SPRY2 FGF9 KL-2 CNTRL-p-2Y-FGFR1 fusion FGF2(10-155) FGF9 UBB(153-228) FGFR1OP-p-FGFR1 fusion HSHS FGF23(25-251) SPRED2 FGF3 FGF20 BAG4(1-126):FGFR1(208-822) fusion ATPKL-1 PIK3R1 KL-1 p-8Y-FGFR1b UBC(229-304) UBC(533-608) FGF1 FGF6 PPP2R1A FGF17-1 FGF4 GRB2-1 FGF23(25-251) p-Y699-STAT5B ZMYM2-p-2Y-FGFR1 fusion FGF18 PiUBB(77-152) PPP2CA FGF17-1 p-8Y-FGFR1c CUX1-FGFR1 fusion p-8Y-FGFR1c P252T UBC(77-152) FGFR1 N546K ATPKAL1 HS FGF22 FGFR1cFGF1 FGF8-1 UBC(229-304) FGF2(10-155) UBC(153-228) FGF6 UBC(457-532) RPS27A(1-76) FGF2(10-155) FGF4 FGF10 KL-1 p-4Y-PLCG1 SHC1-3 GalNAc-T178-FGF23(25-251) FGF10 GRB2-1pY177-BCR-p-FGFR1 fusion ActivatedFGFR1:p-SHC1UBC(229-304) ADPFGF20 p-8Y-FGFR1b FGF9 p-8Y-FGFR1c FGF4 CUX1-FGFR1 fusion GTPFGF2(10-155) BCR-p-FGFR1 fusion FGF6 FGF9 HS SPRED1/2 dimerFGF6 KL-2 HS UBB(1-76) FGF5-1 FGF3 KL-1 FGF4 OverexpressedFGFR1:TKIsFGF20 FGF3 FGF8-1 p-6Y-FRS2 p-6Y-FRS2 FGF1 GRB2:GAB1FGF5-1 KL-1 FGF8-1 GRB2-1 FGF17-1 FGF10 CNTRL-FGFR1 fusion p-8Y-FGFR1c BCR-p-FGFR1 fusion FGF5-1 FGF6 FGF3 HS NRAS p-8Y-FGFR1c FGF8-1 HS p-Y701-STAT1 UBC(533-608) BCR-p-FGFR1 fusion FGF20 FGF17-1 p-8Y-FGFR1b PIK3CA FGF5-1 p-Y-GAB2 UbFGF8-1 PIK3CA KL-1 PPP2CA FGF6 HS FGF6 GalNAc-T178-FGF23(25-251) BCR-FGFR1 fusion FGF6 ATPFGF10 ActivatedFGFR1:p-FRS:p-PTPN11FGF20 UBB(1-76) ATPKAL1p-Y-GAB2 FGF4 FGF9 HS GalNAc-T178-FGF23(25-251) p-8Y-FGFR1b UBC(381-456) GDP KL-2 FGF8-1 FGF9 UBC(457-532) FGF4 FGF1 UBC(77-152) FGF6 GAB1 p-8Y-FGFR1b FGF5-1 KL-1 FGF10 FGF9 FGFR1c P252X mutantsFGF17-1 p-Y546,Y584-PTPN11 FGF17-1 CNTRL-FGFR1 fusion Tyrosine kinaseinhibitors ofoverexpressed FGFR1FGFR1OP2-FGFR1 fusion UBC(533-608) FGF1 FRS3FGF2(10-155) FGF2(10-155) FGF9 FGFRL1 PI(3,4,5)P3 KL-1 FGF23(25-251) PLCG1 FGF4 BCR-p-FGFR1 fusionmutant dimerFGF3 FGF23(25-251) HS FGF9 FGF2(10-155) GAB1 GalNAc-T178-FGF23(25-251) FGFR1(22-763):TACC1(571-805) fusion FGF8-1 GalNAc-T178-FGF23(25-251) PP2A(A:C):SPRY2HS PPP2CB FGF8-1 UBC(381-456) FGF3 p-8Y-FGFR1b FGF22 p-8Y-FGFR1b Plasma membraneFGFR1 fusion dimersHS FGF22 Activated FGFR1:FRS3FGF8-1 PPP2CA FGF2(10-155) FGF17-1 FGF10 p-8Y-FGFR1c GRB2-1 FGF1 FGF3 UBC(609-684) pY177-BCR-p-FGFR1fusion mutant dimerFGF20 FGF23(25-251) KL-2 FGF6 p21 RAS:GTPFGF22 SRC-1ATPTRIM24-p-2Y-FGFR1 fusion cytosolic p-FGFR1fusion mutantdimersY55/Y227-pSPRY2:CBLCBL UBB(1-76) UBB(153-228) CNTRL-p-2Y-FGFR1 fusion FGF10 ATPERLIN2(1-185):FGFR1(c.-88-822) fusion FGF4 PIK3CAp-8Y-FGFR1b HS ZMYM2-p-2Y-FGFR1 fusion p-6Y-FRS2 p-Y546,Y584-PTPN11 CPSF6-p-2Y-FGFR1 fusion KL-2 FGF22 UBC(153-228) KL-1 BCR-p-FGFR1 fusion FGF3 FGF9 FGF3 FGF5-1 Ubp-T202,Y204-MAPK3 FGF22 KRAS p-8Y-FGFR1c ERLIN2(1-185):FGFR1(c.-88-822) fusion p-Y705-STAT3 KL-1 pY177-BCR-pY-FGFR1mutant:GRB2:p-GAB2FGF9 p-S111,S120-SPRY2ADPFGFR1OP2-p-2Y-FGFR1 fusion RPS27A(1-76) ZMYM2-p-2Y-FGFR1 fusion FGF20 GRB2-1 FGF17-1 FGF5-1 FGFR1OP-p-FGFR1 fusion p-8Y-FGFR1c FGF10 FGF8-1 PIK3R1 HS CNTRL-p-2Y-FGFR1 fusion ADPUBC(77-152) HS HSFGF9 ATPp-5Y-FRS3 RAF/MAP kinasecascadep-8T-FRS2 FGF5-1 MYO18A-FGFR1 fusion FGFR1OP-p-FGFR1 fusion FGF23(25-251) FGF20 FGF3 SPRY2 p-8Y-FGFR1c FGF3 FGF6 FGFR1b-binding FGFsUBC(77-152) PIK3CA FGF22 ATPFGF3 FGFR1c:KAL1Activated FGFR1cP252X mutantsPPA2A (A:C):Y55/Y227p-SPRY2:GRB2KL-2 FGFR1OP2-p-2Y-FGFR1 fusion FGF10 PPP2CA p-8Y-FGFR1 K656E PTPN11 FGF1 p-Y371-CBL p-6Y FGFR1(22-763):TACC1(571-805) fusion FGF8-1 FGF4 KL-1 FGF4 FGF17-1 FGF1 CBL FGFR1c P252T GalNAc-T178-FGF23(25-251) KL-1 HSKL-2 ActivatedFGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1HS KL-2 p-8Y-FGFR1c p-Y-GAB2 GRB2-1 HS GalNAc-T178-FGF23(25-251) UBC(381-456) FGF22 p-Y694-STAT5A KL-2 FGF2(10-155) GRB2-1 FGFR1OP-p-FGFR1fusion mutant dimerpY177-BCR-p-FGFR1 fusion PIK3R1 STAT5A GRB2-1 CBLKL-2 GRB2-1 SPRY2:B-RAFFGFR1c P252S p-8Y-FGFR1c p-8Y-FGFR1c FGF10 UBC(305-380) PPP2R1A FGF2(10-155) ActivatedFGFR1:p-FRS:PTPN11FGF3 FGF2(10-155) FGF4 MYO18A-FGFR1 fusion GalNAc-T178-FGF23(25-251) TRIM24-FGFR1 fusion FGF1 p-8Y-FGFR1c KL-2 cytosolic p-FGFR1fusion mutantdimersp-8Y-FGFR1c FGF1 UBC(609-684) FGF2(10-155) FGF4 FGF6 FLRT1 UBC(305-380) p-8Y-FGFR1c FGF17-1 ActivatedFGFR1:p-FRS2FGFR1OP2-FGFR1 fusion FGF6 Tyrosine kinaseinhibitors of FGFR1fusion mutantsFGFR1 mutant dimerswith enhancedkinase activityFGF22 p-Y371-CBL:GRB2FGF20 FGF22 HS LRRFIP1-FGFR1 fusion HS HS ATPGAB1 UBC(153-228) ATPActivatedFGFR1:p-FRS3FGF22 FGFR1c P252R p-8Y-FGFR1c ADPFGF1 p-6Y-FRS2 STAT3 p-4Y-PLCG1GalNAc-T178-FGF23(25-251) ZMYM2-FGFR1 fusion UBC(1-76) FGF4 UBB(153-228) p-8Y-FGFR1c p-8Y-FGFR1b KAL1:HSPP2A(A:C):Y55/Y227-pSPRY2GalNAc-T178-FGF23(25-251) FGFR1c FLRT2 p-Y55,Y227-SPRY2 PP2A (A:C)FGF10 CPSF6-p-2Y-FGFR1 fusion FGF5-1 p-8Y-FGFR1b FGF10 SOS1 FGF1 ATPUBB(1-76) FGF17-1 FGF20 FGF8-1 FGF8-1 SOS1 Overexpressed FGFR1homodimersFGF4 pY177-BCR1-p-FGFR1mutant:GRB2:GAB2p-6Y-FRS2 Plasma membrane p-YFGFR1 fusion dimersFGF10 pY177-BCR-p-FGFR1 fusion p-Y371-CBL Activated FGFR1p-Y546,Y584-PTPN11 PIK3R1 CUX1-p-2Y-FGFR1 fusion PP2A(A:C):S112/S121-pSPRY2FGFR1OP2-FGFR1 fusion FGF10 p-6Y-FRS2 FLRT1 FGF5-1 FGF20 FGF20 ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion p-8Y-FGFR1b FGF20 FGF23(25-251) FRS2 FGF3 GalNAc-T178-FGF23(25-251) FGFR1b FGF8-1 UBC(1-76) FGFR1 R576W p-8Y-FGFR1c FGF23(25-251) FGF9 p-6Y-FRS2 FGF9 FGF4 FGFR1b FGF17-1 FGF4 CNTRL-FGFR1 fusion PPP2R1A LRRFIP1-FGFR1 fusion p-6Y-FRS2 LRRFIP1-FGFR1 fusion p-STAT5A, p-STAT5BLRRFIP1-p-2Y-FGFR1 fusion GalNAc-T178-FGF23(25-251) FGFR1c homodimerATPFGF5-1 p-Y55,Y227-SPRY2 FGF9 FGF4 GalNAc-T178-FGF23(25-251) FRS3 FGF20 PPP2R1A KL-1 p-8Y-FGFR1b FGFRL1-bindingFGFs:FGFRL1 dimerKL-2 FGF1 FGF17-1 FGF9 cytosolic FGFR1fusion mutantsFGF5-1 KL-1 KL-1 UBC(533-608) DAG and IP3signalingPPA2A(A:C):S112/S115p-SPRY2FGF6 FGF3 RPS27A(1-76) MYO18A-p-2Y-FGFR1 fusion FGF1 GRB2-1 HS p-8Y-FGFR1c P252S UBB(153-228) BAG4(1-126):FGFR1(208-822) fusion UBB(77-152) p-Y546,Y584-PTPN11 FGF20 UBC(609-684) SPRED1 p-8Y-FGFR1c ADPATPFGF20 PTPN11FGF22 FGF2(10-155) GTP FGF6 FGF10 FGF10 p-8Y-FGFR1c FGF1 p-8Y-FGFR1 N546K PPP2CB FGF10 FGF22 GalNAc-T178-FGF23(25-251) ADPp-Y546,Y584-PTPN11 KL-2 p-T,Y MAPK dimersFGF17-1 p-T250,T255,T385,S437-MKNK1FGFR1c p-Y239,Y240,Y317-SHC1-2 FGF5-1 FGF5-1 PI(3,4,5)P3ADPCUX1-p-2Y-FGFR1 fusion FGF2(10-155) UBC(1-76) ADPFGF20 UBA52(1-76) ADPActivated FGFR1cbound toFGF23:KlothoFGFRL1 FGF23(25-251) FGF9 ATPFGFR1bUBC(457-532) FGF6 GRB2-1 UBA52(1-76) PPP2CB FGF5-1 UBC(305-380) ADPUBC(153-228) FGF1 FGFR1 K656E FGF23(25-251) ADPFGF20 KL-1 FGF10 FGFR1OP2-p-2Y-FGFR1 fusion FGF18 FGF9 FGF20 ATPUBC(533-608) FGF1 FGF10 p-8Y-FGFR1c p-8Y-FGFR1b PPP2CB ActivatedFGFR1:p-FRS2:GRB2:SOS1GRB2-1 FGF9 ADPp-6Y-FRS2 FGF22 ActivatedFGFR1:p-FRSFGF9 PIK3R1 KL-2 UBC(609-684) FGF1 FGF6 FGF22 HS HS FGF9 FGF8-1 ActivatedoverexpressedFGFR1c homodimerActivatedFGFR1:p-SHC1:GRB2:SOS1FGFR1OP-FGFR1 fusion p-8Y-FGFR1b FGF8-1 KL-2 BRAFp-4Y-PLCG1 FGF6 UBA52(1-76) FGF2(10-155) FGF5-1 GRB2:GAB1:PIK3R1PPP2R1A FGF6 BAG4(1-126):p-8Y FGFR1(208-822) fusion KL-1 BRAF GalNAc-T178-FGF23(25-251) FGFR1 R576W FGF1 activatedFGFR1:PLCG1FGF2(10-155) FGF2(10-155) KL-1 FGF9 FGF5-1 KL-2 FGF6 FGF1 S111/S120p-SPRY2:B-RAFFGFR1c FGF2(10-155) FGF23(25-251) FGF2(10-155) FGF4 UBB(1-76) FGF22 Klotho bound toFGF23ADPFGF4 FGF2(10-155) FGF17-1 cytosolic activated FGFR1 fusion mutants FGF1 FGF1 Ub-Activated FGFR1complex:Ub-p-FRS2FGF23(25-251) SHC1-2 ATPKL-1 FGF2(10-155) TRIM24-FGFR1 fusion GAB1 ActivatedFGFR1:p-FRS2:p-PTPN11RPS27A(1-76) PPP2R1A FRS2FGF1 cytosolic FGFR1fusion mutantdimersFGF10 PIK3R1 Ub:Y55/Y227-pSPRY2:CBLp-6Y-FRS2 KL-1 GalNAc-T178-FGF23(25-251) PPP2CA p-Y194,Y195,Y272-SHC1-3 GalNAc-T178-FGF23(25-251) GalNAc-T178-FGF23(25-251) GRB2-1 GalNAc-T178-FGF23(25-251) KAL1 FGF17-1 GRB2-1:SOS1p-8Y-FGFR1b FGF22 Activated FGFR1mutants andfusion:p-PLCG1cytosolic activated FGFR1 fusion mutants UBC(77-152) FGFR1OP-p-FGFR1 fusion p-8Y-FGFR1b ATPBCR-FGFR1 fusion ATPFGF20 FGF8-1 FGF2(10-155) FGF20 TRIM24-FGFR1 fusion FGF22 CPSF6-FGFR1 fusion FGF6 UBB(77-152) Ub-(Y55/Y227)p-SPRY2FGF2(10-155) KL-2 LRRFIP1-p-2Y-FGFR1 fusion GRB2-1 p-5Y-FRS3 FGF23(25-251) ActivatedFGFR1:p-FRS2:GRB2:GAB1:PIK3R1FGFR1c P252S UBB(77-152) Activated FGFR1mutants and fusionsp-8Y-FGFR1c ZMYM2-FGFR1 fusion FGF20 GalNAc-T178-FGF23(25-251) p-T185,Y187-MAPK1 UBC(229-304) CPSF6-p-2Y-FGFR1 fusion FGF8-1 FGF9 HS FGF20 FGF17-1 GalNAc-T178-FGF23(25-251) FGF5-1 HS HS CUX1-FGFR1 fusion CPSF6-FGFR1 fusion p-8Y-FGFR1c NRAS p-Y239,Y240,Y317-SHC1-2 Activated FGFR1 mutants FGF20 FGF4 FGF20 p-5Y-FRS3 FGFR1OP2-p-2Y-FGFR1 fusion p-8Y-FGFR1b FGF1 FGF23 bound toKlotho and FGFR1cFGF8-1 FGF3 FGFRL1 dimerp-FGFR1 mutantfusions:PI3KGAB2 FGF10 FGFR1 N546K GRB2-1 FGF4 FGF1 HS p-8Y-FGFR1b FGF22 SPRED1 ZMYM2-FGFR1 fusion FGFR1c pY-STAT1,3FGF2(10-155) FGFR1c P252R TRIM24-p-2Y-FGFR1 fusion STAT1,3STAT1 KL-2 FGF22 FGF22 p-S112,S115-SPRY2 GalNAc-T178-FGF23(25-251) FGF4 FGF17-1 KL-2 FGF3 PIK3CA FGF1 GRB2-1 BCR-p-FGFR1 fusion FGF2(10-155) HS HSFGF4 FGF3 FGFR1OP-FGFR1 fusion FGF23(25-251) UBC(305-380) FGF17-1 FGF22 plasma membraneFGFR1 fusionsHS FGF4 FGFR1c P252T CUX1-p-2Y-FGFR1 fusion GAB2 FGF4 FGF1 GAB1 UBC(381-456) PPP2CB FGF2(10-155) UBB(153-228) FGFR1 fusion mutantdimers:TKIsActivated FGFR1 mutants FGF6 FGF3 FLRT2 FLRT3 KL-2 FGF23(25-251) p-8Y-FGFR1c ADPFGF9 FGF5-1 GAB1 FGF20 FGF6 PLCG1FGF10 FGFRL1-binding FGFsFGF4 FGFR1c KL-1 SHC1-3 FGF17-1 FGF2(10-155) p-Y194,Y195,Y272-SHC1-3 FGF20 FGFR1OP-FGFR1 fusion PIK3R1 Activated FGFR1:FLRTFGF1 GRB2-1 p-8Y-FGFR1b KL-1 MYO18A-p-2Y-FGFR1 fusion p-8Y- FGFR1 R576W FGF6 pY177-BCR-p-FGFR1 fusion FGF8-1 KRAS FGF23(25-251) FGF10 ADPKL-1 SPRY2 FGFR1(22-763):TACC1(571-805) fusion p-Y55,Y227-SPRY2 KL-2 FGF3 FGF17-1 FGF23(25-251) GalNAc-T178-FGF23(25-251) p-8Y-FGFR1b GRB2-1 PLCG1 p-8Y-FGFR1b GalNAc-T178-FGF23(25-251) HS p-Y546,Y584-PTPN11 FGF5-1 KL-2 UBC(381-456) ActivatedoverexpressedFGFR1b homodimerFGF17-1 Activated FGFR1:FRS2HS PPP2CA FGFRL1dimer:SPRED1/2dimerFGF22 STAT5B FGF23(25-251) FGF6 PPP2R1A p-8Y-FGFR1b ATPFGF8-1 FGF2(10-155) FGF6 pY177-BCR-pY-FGFR1mutant:GRB2:p-GAB1:PI3KpY177-BCR-p-FGFR1 fusion FGF4 FGF8-1 BRAF p-8Y-FGFR1b ADPFGF6 FGF23(25-251) p-8Y-FGFR1c ZMYM2-p-2Y-FGFR1 fusion CPSF6-FGFR1 fusion HS FGFR