Signaling by FGFR4 (Homo sapiens)

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1, 6, 13, 20, 26...455, 37829, 22, 68, 779, 31, 63, 8511, 19, 51, 598, 11, 5938, 8517, 32, 60, 7028, 48, 55, 623, 548, 34, 6346, 66, 8325, 3982492, 9, 6814, 57, 66451638, 8524, 33, 837816, 21, 42, 50, 698828, 7230, 67, 68, 72, 8530, 31, 7231, 34, 72, 8541, 44, 71, 892, 9, 22, 6817, 32, 44, 60, 70...38, 8531, 343946, 6631, 48, 584526, 29764933, 7914, 7835, 3918, 52, 56, 61cytosolUBC(457-532) FGF8-1 UBB(77-152) FGFR4 FGFR4 mutant dimerswith enhancedkinaseactivity:PD173074FGFR4:HS:KLB:FGF19FGF17-1 KLB KLB FGF1 GRB2-1 CBLFGF6 GalNAc-T178-FGF23(25-251) PI(3,4,5)P3FGF20 p-4Y-PLCG1FGF2(10-155) FGF19 FGFR4 N535K ActivatedFGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2FGF6 FGF17-1 FGF20 FGF8-1 p-Y194,Y195,Y272-SHC1-3 HS ATPFGF2(10-155) PI(3,4,5)P3GalNAc-T178-FGF23(25-251) FGF1 ActivatedFGFR4:p-FRS:PTPN11p-5Y-FGFR4 PIK3R1 HS PPP2R1A SOS1 FGF8-1 FGF20 FGF9 ActivatedFGFR4:p-FRS3KLB UBC(457-532) p-6Y-FRS2 GalNAc-T178-FGF23(25-251) GalNAc-T178-FGF23(25-251) UBB(1-76) SHC1-2 PIP3 activates AKTsignalingFGF19 p-Y55,Y227-SPRY2 Activated FGFR4:SHC1HS FGF9 FGF19 FGF19 FGF16 UBC(229-304) FGF8-1 PPP2CA FGF17-1 FGF19 FGF18 FGF4 UBB(1-76) FGF9 FGF6 ADPFGF16 FGF4 KLB p-6Y-FRS2 GalNAc-T178-FGF23(25-251) FGF17-1 FGF9 FGF4 FGF19 HRAS UBC(1-76) p-5Y-FGFR4 N535D FGFR4 N535D FGF1 FGF6 FGF9 FGF20 FGF1 FGF19 p-5Y-FGFR4 NRAS ADPUBC(229-304) FGF2(10-155) KLB GRB2:GAB1:PIK3R1ADPUBC(229-304) HS CBL FGF18 p-5Y-FGFR4 FGF17-1 FGF4 p-8T-FRS2 Activated FGFR4enhanced kinasemutantsFGF2(10-155) S111/S120p-SPRY2:B-RAFFGF20 FGF18 HS FGF2(10-155) p-T185,Y187-MAPK1 FGF1 FGF2(10-155) FGF4 p-5Y-FGFR4 BRAF PIK3R1FGF16 FGFR4p-5Y-FGFR4 FGF8-1 PP2A(A:C):S112/S121-pSPRY2PPP2CA BRAFATPFGF17-1 FGF16 FGF9 HS GDPactivatedFGFR4:PLCG1SHC1-3 FGF8-1 FGF4 GalNAc-T178-FGF23(25-251) FGF6 p-5Y-FGFR4 V550L UBC(381-456) FGF2(10-155) FGF6 p-6Y-FRS2 FGF9 PLCG1PPP2CA UBC(457-532) GalNAc-T178-FGF23(25-251) FGF4 FGF2(10-155) FGF20 PIK3R1 FGF16 GalNAc-T178-FGF23(25-251) FGF1 GalNAc-T178-FGF23(25-251) FGF6 FGF9 FGF9 RPS27A(1-76) ADPFGF4 p-5Y-FGFR4 p-5Y-FGFR4 HSp-5Y-FGFR4 UBC(1-76) FGF1 FGF18 FGF17-1 p-Y55,Y227-SPRY2 p-Y546,Y584-PTPN11 Ub-Activated FGFR4complex:Ub-p-FRS2KLB KRAS PLCG1 FGF8-1 FGF18 GAB1 KLB UBC(457-532) SHC1-3 FGF20 FGFR4 V550L p-5Y-FGFR4 FGF6 PPP2CB p-Y371-CBL FGF4 p-S112,S121-SPRY2 UBB(153-228) FGF2(10-155) FGF16 KLB FGF18 UBC(153-228) HRAS FGF1 ADPFGF17-1 UBB(153-228) UBC(77-152) FGF2(10-155) FGF2(10-155) FGF18 FGF6 GRB2-1 FGF18 FGF9 FGF2(10-155) FGF4 UBC(153-228) FGF6 FGF4 p-6Y-FRS2 UBB(77-152) FGF8-1 FGF18 p-Y546,Y584-PTPN11 UBC(77-152) KLB ADPGRB2-1 UBB(1-76) GRB2-1:SOS1FGF20 FGFR4 enhancedkinase mutantdimersFGF8-1 UBB(77-152) GalNAc-T178-FGF23(25-251) PPP2R1A UBB(153-228) FGF16 FGF18 PIK3CAKRAS FGF6 ActivatedFGFR4:p-FRSp-Y546,Y584-PTPN11 UBC(1-76) FGF8-1 p-Y239,Y240,Y317-SHC1-2 FGF1 FGF16 GRB2:GAB1FGF1 FGF4 FGF20 KLB FGF20 UBC(609-684) FGF6 FGF8-1 GalNAc-T178-FGF23(25-251) PiFGF18 GalNAc-T178-FGF23(25-251) ADPUBC(1-76) p-5Y-FGFR4 p-Y546,Y584-PTPN11 FGFR4 Y367C mutantdimerFGF1 FGF2(10-155) FGF2(10-155) FGFR4 Y367C UBB(77-152) p-Y55,Y227-SPRY2 FGF8-1 HS SHC1 p46,p52FGF18 UBB(77-152) p-5Y-FGFR4 N535K KLB p-4Y-PLCG1 FGF9 UBC(609-684) UBC(609-684) FGF17-1 FGF20 FGF2(10-155) SRC-1p21 RAS:GTPActivatedFGFR4:p-FRS2:GRB2:GAB1:PI3KGRB2-1 HS FGF20 GRB2-1 FGF17-1 p-5Y-FRS3 FGFR4 Y367CFGF2(10-155) UBC(305-380) UBB(153-228) KLB FGF6 RPS27A(1-76) FGF17-1 p-Y239,Y240,Y317-SHC1-2 FGF4 HS p-6Y-FRS2 FGF9 KLB FGF6 p-6Y-FRS2 p-5Y-FRS3 UBC(305-380) HSFGF2(10-155) ActivatedFGFR4:p-FRS2:p-PTPN11FGF17-1 p-5Y-FGFR4 FGF1 p-Y371-CBL FGF16 p-Y55,Y227-SPRY2 FGF8-1 p-6Y-FRS2 p-5Y-FGFR4 FGF19 p-5Y-FGFR4 V550E HS FGF6 KLB HS FGF18 FGF1 PPP2R1A HS FGF9 ADPFGF6 FGF6 FGF20 p-5Y-FRS3 GRB2-1 FGF19 p-T,Y MAPK dimersUBA52(1-76) HS KLB GRB2-1 FGF17-1 PIK3R1 PIK3R1 FGFR4 V550L UBC(533-608) FGF8-1 FGF18 HS FGF19 FGF20 FGF9 ActivatedFGFR4:p-FRS2:GRB2:GAB1:PIK3R1FGFR4 N535K p-5Y-FRS3 FGF19 FGF4 FGF1 FGF17-1 FGF19 FGF4 FGF16 FGF1 GAB1 FGF4 GRB2-1 GalNAc-T178-FGF23(25-251) FGF18 GRB2-1 FGF19 PPP2CA FGFR4 N535K FGF18 p-5Y-FGFR4 FGF19 FGF16 GalNAc-T178-FGF23(25-251) p-Y546,Y584-PTPN11 HS PPA2A (A:C):Y55/Y227p-SPRY2:GRB2FGF4 FGF9 FGF8-1 PP2A(A:C):SPRY2GAB1 PPP2CB FGF18 FGF1 ATPFGFR4 N535D FGF18 ATPFGF2(10-155) FGF1 FGF8-1 FGF17-1 KLB HS UBC(153-228) FGF4 FGF2(10-155) UBC(1-76) FGFR4 V550L FGF9 FGF18 PPP2R1A FGF16 FGF19 Activated FGFR4FGF9 RPS27A(1-76) ADPFGF20 FGF1 FGF16 UBC(305-380) KLB FGF16 FGF8-1 GTP ATPKLB UBC(77-152) PPP2R1A GTPHS Ub:Y55/Y227-pSPRY2:CBLFGF20 GAB1 FGF16 PPP2CB FGF20 FGF17-1 FGF17-1 SOS1 Activated FGFR4:FRS3UBC(533-608) PPA2A(A:C):S112/S115p-SPRY2FGFR4 homodimerbound to FGFFGF8-1 FGF20 GalNAc-T178-FGF23(25-251) NRAS GRB2-1 Activated FGFR4homodimerFGF6 BRAF FGF2(10-155) FGF8-1 SHC1-2 PD173074 HS UBC(229-304) UBA52(1-76) GAB1 p-6Y-FRS2 FGF18 FGF16 ATPFGFR4 ATPp-Y55,Y227-SPRY2 FGF16 FGF4 KLBFGF16 GalNAc-T178-FGF23(25-251) GRB2-1 p-5Y-FGFR4 PI(3,4,5)P3 KLB RPS27A(1-76) p-5Y-FGFR4 FGF6 FGF17-1 FGF16 SOS1 FGF19 UBC(77-152) HS FGF16 FGFR4 V550E FGF2(10-155) FGF19 FGF20 ActivatedFGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1FGF2(10-155) p-Y194,Y195,Y272-SHC1-3 FGF9 ActivatedFGFR4:pY-SHC1FGF19 PPP2CA FGF16 ActivatedFGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3KHS FGF16 p-T202,Y204-MAPK3 UBC(381-456) ATPFGF17-1 FRS3 UBB(1-76) FGF19 UBC(533-608) ActivatedFGFR4:p-FRS:p-PTPN11p-6Y-FRS2 PPP2CA FGF20 SPRY2:B-RAFFGF6 FGF6 Ub-(Y55/Y227)p-SPRY2activatedFGFR4:p-4Y-PLCG1UBC(153-228) FGF4 FGF2(10-155) FGF18 PI(4,5)P2PPP2CB FGF19 ATPp-5Y-FGFR4 Activated FGFR4Y367C mutantSPRY2 UBC(381-456) HS KLB UBB(1-76) UBC(609-684) FGF1 FRS2 KLB GRB2-1 p-5Y-FGFR4 FGF4 UBB(153-228) FGF16 KLB FGF19 GalNAc-T178-FGF23(25-251) FGF8-1 UBC(533-608) ActivatedFGFR4:pY-SHC1:GRB2:SOS1FGF1 FGF19 PIK3CA HS UBC(533-608) GalNAc-T178-FGF23(25-251) FGF6 PTPN11GalNAc-T178-FGF23(25-251) p-Y546,Y584-PTPN11 FGF17-1 FGFR4-binding FGFsFGF19PIK3R1 FGF18 FGF20 RAF/MAP kinasecascadeFGF6 GalNAc-T178-FGF23(25-251) UBC(153-228) p-6Y-FRS2 UBC(609-684) GalNAc-T178-FGF23(25-251) RPS27A(1-76) PTPN11 ActivatedFGFR4:p-8T-FRS2GRB2-1 p5Y-FGFR4 Y367C mutant FGF19 FGF6 GRB2-1ADPHS PPP2CB p-5Y-FGFR4 FRS2FGF20 FGFR4 V550E ATPFGF19 PPP2R1A UbActivated FGFR4bound toFGF19:BetaKlothoFGF1 FGF19 CBL HS PPP2CA FGF9 ADPFGF4 PPP2CB p21 RAS:GDPFGF17-1 PP2A(A:C):Y55/Y227-pSPRY2GalNAc-T178-FGF23(25-251) FGF16 KLB p-5Y-FGFR4 UBC(457-532) FGF20 Activated FGFR4:FRS2ActivatedFGFR4:p-FRS2:GRB2:SOS1SPRY2 p-6Y-FRS2 FGF9 SPRY2 p-5Y-FRS3 FGF18 p-6Y-FRS2 p-S111,S120-SPRY2 p-5Y-FGFR4 FGFR4 V550E FGF9 GAB1 FGF4 KLB FGF9 FGF8-1 p-5Y-FGFR4 PPP2R1A FGF19 PP2A (A:C)UBC(381-456) FGF16 PPP2CB ATPp-5Y-FGFR4 FGF8-1 FGF17-1 GalNAc-T178-FGF23(25-251) FGF2(10-155) FGF9 FGF17-1 Y55/Y227-pSPRY2:CBLFGF6 FGF18 FGFR4 N535D FRS3FGF9 p-Y371-CBL GDP FGF1 FGF8-1 FGF17-1 FGF2(10-155) DAG and IP3signalingUbFGF20 UBC(381-456) ATPFGFR4 enhancedkinase mutantsFGF18 UBA52(1-76) FGF9 FGF4 FGF1 PPA2A(A:C):SPRY2GalNAc-T178-FGF23(25-251) PIK3CA FGF4 p-5Y-FGFR4 FGF17-1 p-Y371-CBL:GRB2FGF8-1 UBA52(1-76) ADPGalNAc-T178-FGF23(25-251) HS UBC(229-304) FGF19 UBA52(1-76) p-S112,S115-SPRY2 FGF1 p-T250,T255,T385,S437-MKNK1FGF8-1 FGF1 p-5Y-FGFR4 UBC(305-380) p-S111,S120-SPRY2ActivatedFGFR4:p-FRS2UBC(77-152) FGF20 PD173074UBC(305-380) 284578454, 12, 23, 36, 40...453945394510, 15, 27, 4345164545393910, 15, 27, 4345454545741645717, 32, 60, 7045454545