SUMOylation of DNA damage response and repair proteins (Homo sapiens)

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1, 2, 7, 17, 33...11, 49, 50, 586329, 18, 28, 4911, 443, 11, 48, 498, 13, 43, 48, 6623, 24, 465, 16, 27, 49, 615621, 4922364, 20, 21, 24, 26...19, 424, 8, 20, 24, 34...8, 10, 2165011, 21, 24, 3515, 25, 29, 37, 5111, 15, 31, 4918, 28, 5714, 62, 64nucleoplasmSUMO2-C93-UBE2I PIAS4SUMO1:C93-UBE2ISMC6 SUMO1-K297-SP100 PIAS1,2-1SUMO3-C93-UBE2I SUMO1:C93-UBE2IRNF2 UBE2ITPR RAE1 PIAS4UBE2IEID3 MDC1-G97-SUMO1 K65-PML-G97-SUMO1 UBE2I-G92-SUMO3 K486-PARP1-G97-SUMO1 SUMO1-C93-UBE2I SUMO2:UBE2INUP205 RAD21 RPA1SUMO3-K65,K160,K490-PMLK356-WRN-G97-SUMO1 SMC1A SUMO1:C93-UBE2INUP50 SUMO2-C93-UBE2I SP100-G97-SUMO1 PHC1 NUP93 BLMPOM121C UBE2I-G92-SUMO3 PRC1 complexPIAS1 PIAS1,4PMLSUMO1-K-RAD21 3SUMO1:RAD52NUP54 UBE2I-G97-SUMO1 XRCC4-G97-SUMO1 XRCC4CBX2 UBE2I-G97-SUMO1 SUMO2,3-BRCA1UBE2I-G97-SUMO1 PCGF2 BRCA1NUP43 UBE2I-G97-SUMO1 HERC2-SUMO1 UBE2I-G92-SUMO3 SUMO2-C93-UBE2I WRNNUP98-5 SUMO2-K297-SP100NUP160 UBE2I-G93-SUMO2 RAD52SUMO1-K-STAG2 SUMO1-RNF168 SUMO1-C93-UBE2I SUMO1-C93-UBE2I STAG2 SP100SUMO1-C93-UBE2I UBE2I-G97-SUMO1 NSMCE4A UBE2I-G97-SUMO1 PIAS4UBE2ISUMO1-K203,K486-PARP1 UBE2I:SUMO2,UBE2I:SUMO33SUMO1:WRNSUMO1:C93-UBE2IUBE2I-G97-SUMO1 SUMO1:C93-UBE2ISUMO1:MDC1BRCA1-G97-SUMO1 UBE2I-G93-SUMO2 SUMO3:UBE2IUBE2ISUMO1:C93-UBE2ISUMO2,3-K330-TDGSUMO1-C93-UBE2I SUMO1:C93-UBE2INUP214 NUP153 NDNL2 UBE2I:SUMO2,UBE2I:SUMO3UBE2IUBE2I-G92-SUMO3 K490-PML-G97-SUMO1 NUP35 SUMO1-HERC2 UBE2I-G93-SUMO2 RNF168-SUMO1 SUMO2-C93-UBE2I XPCSUMO1:XRCC4SUMO3-C93-UBE2I NUP37 NUP98-4 SMC3 STAG1 NUP133 POM121 RING1 UBE2INUP62 RANBP2 SUMO1-K411,K412,K414-RAD52 UBE2I:SUMO2,UBE2I:SUMO3UBE2I-G97-SUMO1 SUMO1-C93-UBE2I K411-RAD52-G97-SUMO1 SMC5-SMC6 ComplexK160-PML-G97-SUMO1 SMC3 UBE2I-G97-SUMO1 PARP1CBX4 SUMO1-K210-XRCC4 NUP88 SUMOylated CohesinSUMO3-C93-UBE2I SUMO1:RNF168UBE2I-G97-SUMO1 SUMO1-C93-UBE2I SUMO2,3-K1840-MDC1UBE2I,HDAC7PIAS4 SUMO1:C93-UBE2IUBE2ISUMO1-K109-BRCA1 SUMO2,3-CETN2NSMCE1 UBE2I-G92-SUMO3 UBE2IPHC2 BMI1 SEH1L-2 RNF168UBE2I-G97-SUMO1 NUPL1-2 SUMO1-C93-UBE2I 3SUMO1:PMLCohesin ComplexSUMO1:BRCA1SUMO1-K1840-MDC1 SUMO1-K356,K496,K898-WRN PIAS2-1 SUMO2-C93-UBE2I UBE2I-G93-SUMO2 SUMO2-C93-UBE2I MDC1UBE2IUBE2IK203-PARP1-G97-SUMO1 SUMO2-C93-UBE2I SUMO1-C93-UBE2I SUMO2-C93-UBE2I UBE2I-G93-SUMO2 UBE2I:SUMO2,UBE2I:SUMO3UBE2I XPC-G97-SUMO1 SUMO1:C93-UBE2ISUMO1-C93-UBE2I UBE2I-G92-SUMO3 SMC1A SUMO1-K65,160,490-PML K496-WRN-G97-SUMO1 UBE2ITDG-G97-SUMO1 SUMO1:C93-UBE2ISUMO2,3-K203,K486-PARP1CETN2STAG1 UBE2I-G92-SUMO3 p14-ARFUBE2INSMCE2 CBX8 SMC5 SUMO3-C93-UBE2I NDC1 PHC3 RAD21-G97-SUMO1 SUMO2-C93-UBE2I SUMO1:HERC2SUMO1-K655-XPC SUMO2,3-K449,K577-RPA1K414-RAD52-G97-SUMO1 UBE2I-G93-SUMO2 NUP155 UBE2I:SUMO2,UBE2I:SUMO3SUMO1:SP100NUP188 SUMO3-C93-UBE2I SUMO1:C93-UBE2ISUMO2-K65,K160,K490-PMLUBE2I-G93-SUMO2 UBE2I-G92-SUMO3 TDGHERC2SUMO1:XPCUBE2I-G97-SUMO1 UBE2IAAAS K898-WRN-G97-SUMO1 2SUMO1:PARP1SUMO3-C93-UBE2I NUPL2 UBE2I:SUMO2,UBE2I:SUMO3HDAC7 Nuclear Pore Complex(NPC)SUMO1-K330-TDG SUMO2:UBE2IUBE2I-G97-SUMO1 UBE2ISUMO3-C93-UBE2I SUMO1:C93-UBE2IUBE2INUP210 SCMH1-2 Nup45 STAG2-G97-SUMO1 SUMO1-C93-UBE2I SUMO3-C93-UBE2I UBE2I4SUMO2,3-BLMSUMO1-C93-UBE2I UBE2I-G93-SUMO2 UBE2I:SUMO2,UBE2I:SUMO3PIAS1 NUP85 SUMO1-C93-UBE2I NUP98-3 K412-RAD52-G97-SUMO1 NUP107 SUMO1:C93-UBE2IUBE2I-G93-SUMO2 SUMO1:TDG45618, 28, 57633012, 41, 54, 6019, 4250454, 204914, 644, 204511, 49, 5015, 25, 5113, 43, 48454545, 6745, 6745, 6745, 67495332364545, 67623, 463, 11, 48, 496645, 676411, 24, 4645112245, 6711, 31, 494545, 6745, 674959


Several factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferrari 2013, Flotho and Melchior 2013, Jackson and Durocher 2013). SUMOylation can alter enzymatic activity and protein stability or it can serve to recruit additional factors. For example, SUMOylation of Thymine DNA glycosylase (TDG) causes TDG to lose affinity for its product, an abasic site opposite a G residue, and thus increases turnover of the enzyme. During repair of double-strand breaks SUMO1, SUMO2, SUMO3, and the SUMO E3 ligases PIAS1 and PIAS4 accumulate at double-strand breaks where BRCA1, HERC1, RNF168, MDC1, and TP53BP1 are SUMOylated. SUMOylation of BRCA1 may increase its ubiquitin ligase activity while SUMOylation of MDC1 and HERC2 appears to play a role in recruitment of proteins such as RNF4 and RNF8 to double strand breaks. Similarly SUMOylation of RPA1 (RPA70) recruits RAD51 in the homologous recombination pathway. View original pathway at:Reactome.


Pathway is converted from Reactome ID: 3108214
Reactome version: 61
Reactome Author 
Reactome Author: May, Bruce

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101555view11:42, 1 November 2018ReactomeTeamreactome version 66
101091view21:25, 31 October 2018ReactomeTeamreactome version 65
100620view19:59, 31 October 2018ReactomeTeamreactome version 64
100171view16:44, 31 October 2018ReactomeTeamreactome version 63
99721view15:11, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99295view12:46, 31 October 2018ReactomeTeamreactome version 62
93901view13:43, 16 August 2017ReactomeTeamreactome version 61
93474view11:24, 9 August 2017ReactomeTeamreactome version 61
88418view11:53, 5 August 2016FehrhartOntology Term : 'sumoylation pathway' added !
86571view09:21, 11 July 2016ReactomeTeamreactome version 56
83291view10:40, 18 November 2015ReactomeTeamVersion54
81424view12:57, 21 August 2015ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
2SUMO1:PARP1ComplexR-HSA-4551687 (Reactome)
3SUMO1:PMLComplexR-HSA-3730883 (Reactome)
3SUMO1:RAD52ComplexR-HSA-4568880 (Reactome)
3SUMO1:WRNComplexR-HSA-4568903 (Reactome)
4SUMO2,3-BLMProteinP54132 (Uniprot-TrEMBL)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMI1 ProteinP35226 (Uniprot-TrEMBL)
BRCA1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
CBX2 ProteinQ14781 (Uniprot-TrEMBL)
CBX4 ProteinO00257 (Uniprot-TrEMBL)
CBX8 ProteinQ9HC52 (Uniprot-TrEMBL)
CETN2ProteinP41208 (Uniprot-TrEMBL)
Cohesin ComplexComplexR-HSA-1641505 (Reactome)
EID3 ProteinQ8N140 (Uniprot-TrEMBL)
HDAC7 ProteinQ8WUI4 (Uniprot-TrEMBL)
HERC2-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
HERC2ProteinO95714 (Uniprot-TrEMBL)
K160-PML-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K203-PARP1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K356-WRN-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K411-RAD52-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K412-RAD52-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K414-RAD52-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K486-PARP1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K490-PML-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K496-WRN-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K65-PML-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K898-WRN-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
MDC1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
MDC1ProteinQ14676 (Uniprot-TrEMBL)
NDC1 ProteinQ9BTX1 (Uniprot-TrEMBL)
NDNL2 ProteinQ96MG7 (Uniprot-TrEMBL)
NSMCE1 ProteinQ8WV22 (Uniprot-TrEMBL)
NSMCE2 ProteinQ96MF7 (Uniprot-TrEMBL)
NSMCE4A ProteinQ9NXX6 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188 ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205 ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)