RHO GTPases regulate CFTR trafficking (Homo sapiens)

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1, 221, 22Golgi-associated vesiclelysosomal lumencytosolRHOQ CFTR GOPC RHOQ:GTP:GOPC:CFTRGTP CFTR RHOQ GOPC RHOQ CFTR CFTR RHOQ:GTP:GOPC:CFTRRHOQ:GTPGTP GTP GOPC GOPC GOPC:CFTRGOPC:CFTR2222


Description

Activated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing protein) also known as PIST, FIG or CAL. GOPC is a Golgi resident protein that binds several membrane proteins, thereby modulating their expression. In the absence of RHOQ, GOPC bound to CFTR directs CFTR for lysosomal degradation, while GTP-bound RHOQ directs GOPC:CFTR complex to the plasma membrane, thereby rescuing CFTR (Neudauer et al. 2001, Cheng et al. 2005). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 5627083
Reactome-version 
Reactome version: 61
Reactome Author 
Reactome Author: Orlic-Milacic, Marija

Quality Tags

Ontology Terms

 

Bibliography

  1. Cheng J, Wang H, Guggino WB.; ''Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.''; PubMed
  2. Neudauer CL, Joberty G, Macara IG.; ''PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.''; PubMed

History

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CompareRevisionActionTimeUserComment
101478view11:34, 1 November 2018ReactomeTeamreactome version 66
101016view21:14, 31 October 2018ReactomeTeamreactome version 65
100552view19:48, 31 October 2018ReactomeTeamreactome version 64
100100view16:33, 31 October 2018ReactomeTeamreactome version 63
99650view15:04, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99252view12:45, 31 October 2018ReactomeTeamreactome version 62
93730view12:19, 16 August 2017Mkutmonfix ontology tags
93628view11:29, 9 August 2017ReactomeTeamreactome version 61
89091view08:05, 22 August 2016EgonwOntology Term : 'signaling pathway' added !
86739view09:25, 11 July 2016ReactomeTeamreactome version 56
83283view10:37, 18 November 2015ReactomeTeamVersion54
81409view12:56, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CFTR ProteinP13569 (Uniprot-TrEMBL)
GOPC ProteinQ9HD26 (Uniprot-TrEMBL)
GOPC:CFTRComplexR-HSA-5627082 (Reactome)
GOPC:CFTRComplexR-HSA-5627276 (Reactome)
GTP MetaboliteCHEBI:15996 (ChEBI)
RHOQ ProteinP17081 (Uniprot-TrEMBL)
RHOQ:GTP:GOPC:CFTRComplexR-HSA-5627078 (Reactome)
RHOQ:GTP:GOPC:CFTRComplexR-HSA-5627084 (Reactome)
RHOQ:GTPComplexR-HSA-5627068 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
GOPC:CFTRArrowR-HSA-5627275 (Reactome)
GOPC:CFTRR-HSA-5627072 (Reactome)
GOPC:CFTRR-HSA-5627275 (Reactome)
R-HSA-5627071 (Reactome) While binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes lysosomal degradation of CFTR, binding of active RHOQ to GOPC:CFTR complex redirects CFTR to the plasma membrane and prevents its degradation (Cheng et al. 2005).
R-HSA-5627072 (Reactome) GTP-bound RHO GTPase RHOQ (TC10) binds GOPC (also known as PIST, CAL or FIG) dimer (Neudauer et al. 2001, Cheng et al. 2005) in complex with CFTR (cystic fibrosis transmembrane conductance regulator) on Golgi-associated vesicles (Cheng et al. 2005).
R-HSA-5627275 (Reactome) Binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes translocation of GOPC:CFTR complex to lysosomes, which is followed by lysosomal degradation of CFTR (Cheng et al. 2005).
RHOQ:GTP:GOPC:CFTRArrowR-HSA-5627071 (Reactome)
RHOQ:GTP:GOPC:CFTRArrowR-HSA-5627072 (Reactome)
RHOQ:GTP:GOPC:CFTRR-HSA-5627071 (Reactome)
RHOQ:GTPR-HSA-5627072 (Reactome)
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