Hedgehog 'off' state (Homo sapiens)

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5, 23, 43, 571, 6, 17, 39, 691, 3913, 30, 49, 6221, 31, 35, 68, 8019, 436, 6925, 67, 7025, 67, 708, 22, 30, 49, 61...5, 17, 18, 20, 22...30, 44, 49, 62, 9031, 731, 17, 24, 395, 17, 18, 20, 22...23, 56, 7331, 7321, 23, 31, 35, 56...615, 17, 22, 51-53, 65...25, 6723, 56, 7313, 49, 623, 5, 7, 9, 11...61, 3925, 674, 10, 14, 27, 28, 40...701, 24, 32, 39, 696, 69, 8739, 69, 70, 876, 69endocytic vesicle lumennucleoplasmcytosolciliumPSMA4 RPS27A(1-76) PSMA6 GLI2:SUFUPRKAR2B PSMC3 GLI:SUFUUBC(77-152) PSMB7 PSMB5 ADCY4 p8S-GLI2:SUFUMKS1 SUFU IFT122 UBC(229-304) GLI2 gene:GLI3RUBC(609-684) PSMC2 GLI2 UBC(533-608) UBC(457-532) GPR161:IFT-A:TULP3GLI2 UBB(1-76) UBC(381-456) ADPretrograde IFTregulators of HhADPATPp6S-GLI3:SUFUNUMB:ITCHUBC(457-532) PRKAR2B PRKACA PSMC3 UBB(1-76) GLI1 genePSMB2 PSME3 OFD1 PSMD2 pS-GLI:SUFUUBC(153-228) PTCH1 geneGLI1 SUFU PSMC4 WDR35 PSMB6 ATPUBC(381-456) PTCH1PSMD14 SCF beta-TrCPcomplexATPPPiPSMB9 ATPp4S-GLI2 GLI3 GLI1 GLI:SUFUPTCH1 gene SMO TULP3 TTC21B p4S-GLI2:SUFUPSME1 GLI1 gene:GLI3RSUFU UBC(77-152) SUFU RPS27A(1-76) PSMB9 UBC(533-608) WDR19 SUFU UBC(1-76) SMO dimerPSME1 IFT-A complex:TULP3GLI2 geneGNAS2 GSK3BUBB(153-228) PSMC1 GLI3:SUFUp13S-GLI3 GLI:SUFUPSMC4 PSMB11 WDR19 SHFM1 PSMB3 CSNK1A1ub-pS-GLI1 UBC(305-380) p11S-GLI2:SUFUWDR35 ATPPSMC2 PKA catalyticsubunitGTP IFT57 PSMD1 GLI2 gene PSMD14 IFT172 PSME2 microtubuleADPNUMB IFT52 PSMA7 ADPPSMB1 PSMD4 PSMB8 SHFM1 UBB(77-152) UbGLI1 PRKAR1B PSME2 WDR35 SUFU UBB(153-228) BTRC SUFU SUFU GLI2 SUFU UBC(609-684) PRKAR1A GPR161PSMD5 SUFU UBA52(1-76) 4xub-p13S-Gli3:SUFUSUFURBX1 WDR19 SUFU 26S proteasomeIFT140 FUZ PSMD3 PSMA1 GLI2UBB(1-76) ub-p13S-GLI3 UBC(1-76) GLI3 ITCH GLI1 gene PSMC1 UBC(305-380) ATPPSMA7 PSMC6 p6S-GLI3 TTC21B ADPUBC(305-380) PKA tetramerUBC(229-304) GNAS1 ITCHGLI1,2,3pS-GLI1 PSMA4 UBC(457-532) GLI3 ATPPSMB4 UBC(77-152) GLI3R PSMB7 p11S-GLI2 PSMD11 ub-pS-GLI1 IFT140 PSMD9 SUFU GLI3R PRKACG SCF beta-TrCPcomplexADCY6 RPGRIP1L ITCH UBC(609-684) SMO dimerSUFU UBB(77-152) TULP3GLI2 GPR161 PSMB2 PSMA8 GLI3 KIF3A SUFU PRKAR2A PSMC5 PSMD6 IFT122 PTCH1 gene:GLI3RPSMC5 UbADCY2 SKP1 PSME4 PSMD3 PSMA5 PSMF1 ciliary basal bodyregulators of Hhp10S-GLI3:SUFUIFT88 PRKAR1A KIF7:microtubuleub-p11S-GLI2 IFT122 UBC(533-608) SUFU ADCY8 PSMD13 PSMB10 PSMA5 PSMF1 PSMA2 PSMD11 SMO G-protein alpha(s):GTPPSMA2 PSMB3 ADCY5 INTU PSMB5 SUFU PSMA3 adenylatecyclases:Mg2+PSMB11 DYNC2H1 PSMB8 KIF7 PSMD8 ub-pS-GLI:SUFUPSMA1 TTC21B ADCY3 ADCY9 ub-p11S-GLI2:SUFUGLI2 PSME3 PSMD7 RPS27A(1-76) NUMB PSMB6 26S proteasomePSMB4 UBA52(1-76) PRKAR1B PSMA6 PSMD10 PRKACG PSMD4 ADCY7 IFT122 ATPPRKACB GLI1:SUFUcAMP PSMC6 UBC(153-228) ADPIFT-A complexPRKAR2A UBA52(1-76) PSMD9 SKP1 PSME4 GLI3 PCP regulators of HhPSMB1 RBX1 TULP3 PRKACA GLI1 ADCY1 PSMD5 p10S-GLI3 p13S-GLI3:SUFUADCY10 NUMB:ITCH:ub-pS-GLI1:SUFUPSMD10 PSMA8 PKA regulatorysubunits:cAMPPRKACB PSMA3 PSMD2 PSMD6 KIF7PSMD12 UBC(1-76) CUL1 PSMB10 BTRC UBB(153-228) UBC(153-228) GLI3R SUFU UbTTC21B PSMD7 microtubule GLI3RIFT140 p8S-GLI2 PSMD13 NUMBUBC(229-304) GLI3RGLI1 anterograde IFTregulators of HhADPGLI1CUL1 UBC(381-456) UBB(77-152) PSMD8 cAMPMg2+ PSMD12 PSMD1 1, 392, 6473731, 3921, 391, 39472, 64301, 393068, 802