Hedgehog 'off' state (Homo sapiens)

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43, 66, 68, 8779, 8017, 19, 26, 35, 551, 3-5, 7...52, 74, 816, 10, 47, 48, 60...22, 5516, 38, 42, 64, 73...17, 26, 35, 6548, 66, 8016, 29, 78, 90, 912287, 9352, 8122, 26, 35, 55, 6553, 78, 9079, 8026, 352, 8, 9, 11, 12, 14...26, 3522, 55, 706, 10, 47, 60, 7948, 66, 802252, 8122, 5526, 55, 70, 7452, 74, 8115, 18, 23, 30, 34...749, 20, 27, 31, 32, 36...16, 53, 78, 902, 8, 9, 11, 12, 14...cytosolnucleoplasmendocytic vesicle lumenciliumOFD1 UBC(381-456) ADCY8 ITCH ITCH PSME4 PSMB1 PSMD11 PSMD1 CUL1 PRKACG SUFU ATPPPiBTRC GPR161 PSMD12 UBB(77-152) ADCY7 PSMD3 IFT-A complexUBC(533-608) IFT140 PSMA7 GLI2 PSMC4 PTCH1 gene PSMD8 UBB(153-228) PSMA5 UBC(153-228) ADCY6 microtubuleITCHPSMB10 GLI:SUFUPSMD11 p10S-GLI3:SUFUNUMB:ITCH:ub-pS-GLI1:SUFUIFT57 pS-GLI1:SUFUGLI1,2,3PSMB10 PRKACA Mg2+ GLI3 IFT172 PSMA4 TTC21B UBC(305-380) PSMD6 GLI2 genePSMD9 SMO dimerSHFM1 GNAS2 PSMD5 PSMB6 UBC(609-684) FUZ RPS27A(1-76) SUFU UBC(305-380) UBA52(1-76) PSMF1 PSMD7 CSNK1A1UBC(533-608) PSMD10 PSMA7 PRKAR1B UBC(533-608) PSMD14 GLI1 gene 26S proteasomeUBC(609-684) UBC(1-76) SMO PSMB1 NUMB PSMB7 ADCY2 PSMC4 UBC(381-456) GLI3R PSMC6 PSMB8 microtubule UBC(457-532) 26S proteasomecAMP GLI2 UBB(77-152) INTU SUFU UBC(609-684) p11S-GLI2 ciliary basal bodyregulators of Hhub-pS-GLI1 GSK3BPSME3 NUMB p13S-GLI3 GLI1 PRKAR2B PRKACG IFT122 GLI3RGLI3 BTRC p11S-GLI2:SUFUIFT88 PSMD5 PSMD14 UBC(457-532) IFT52 TULP3 ub-p13S-GLI3 PSMD2 IFT122 PSME2 NUMBPKA tetramerGLI3 WDR35 PSMC5 GLI2:SUFUub-pS-GLI1 UBB(1-76) GPR161UBC(457-532) UBC(1-76) ADPPSMA3 ADCY3 PSMA4 GLI1SKP1 PSME3 ADCY9 PSMF1 SUFU GLI3:SUFUGLI2 PSMB5 GLI3RSUFU PSMD13 UbPSMC2 PSMA2 IFT140 ADCY10 SUFU PSMC5 GLI2 PSMC1 PCP regulators of HhCUL1 PSMA1 PSMA8 GLI1 TULP3 KIF7 p4S-GLI2:SUFUPSME2 ADCY5 PSMB4 UBC(77-152) SUFU PRKAR1B SUFU PTCH1 geneGLI3R ub-p11S-GLI2 PSMA5 anterograde IFTregulators of HhGLI1 gene:GLI3RGLI1 SUFUPSMD13 WDR19 UBC(229-304) UBC(77-152) PSMB9 retrograde IFTregulators of HhADCY1 GLI3R UbTTC21B WDR35 UBB(153-228) SMO PSMB3 MKS1 GLI1 RPS27A(1-76) RBX1 PSMB8 4xub-p13S-Gli3:SUFUPSMC1 GLI2 GPR161:IFT-A:TULP3UBB(1-76) PSMD10 ADPp6S-GLI3 IFT122 cAMPBTRC:CUL1:RBX1:SKP1WDR35 GLI:SUFUWDR19 KIF3A UBC(381-456) p6S-GLI3:SUFUp8S-GLI2 PRKAR1A UBC(305-380) UBC(77-152) PKA regulatorysubunits:cAMPATPPRKAR2A PRKAR2B IFT-A complex:TULP3UBB(77-152) GLI3 ub-p11S-GLI2:SUFUPSMC2 UBC(229-304) p10S-GLI3 TTC21B pS-GLI1 PSMD6 ADCY4 PSMD12 PSMB11 ub-pS-GLI1:SUFUSUFU RBX1 ADPPSMD3 p8S-GLI2:SUFUATPSUFU DYNC2H1 UbPSME1 SKP1 PRKAR2A PSMB11 GLI3 PTCH1PSMA2 IFT140 BTRC:CUL1:RBX1:SKP1PSMB2 SUFU PSMD1 PSMB7 SUFU PSMB6 TTC21B G alpha (s):GTPSUFU ATPATPp4S-GLI2 UBC(1-76) ADPTULP3IFT122 PSMD7 NUMB:ITCHGLI2GLI2 gene:GLI3RATPUBA52(1-76) PSMA1 GLI:SUFUPSMB3 UBC(153-228) PSMC3 PTCH1 gene:GLI3RWDR19 PSMD2 PSMD9 PSMB9 PSMA6 PSMA8 KIF7UBA52(1-76) PKA catalyticsubunitUBB(153-228) GTP PSMB4 PRKAR1A UBB(1-76) ADPGLI2 gene SHFM1 PSMB2 ATPGLI1 SMO dimerSUFU GLI1 genePSME4 PSMD4 PSMC3 PRKACB UBC(153-228) KIF7:microtubuleRPS27A(1-76) ATPSUFU PSMD4 PSMA3 adenylatecyclases:Mg2+SUFU PSMB5 PSMC6 p13S-GLI3:SUFUPSMA6 ADPPSME1 UBC(229-304) GLI1:SUFUPRKACB PRKACA ADPGNAS1 RPGRIP1L PSMD8 SUFU 21, 244510, 4726, 35802126, 3526, 3526, 35162126, 3521, 241680


Hedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh signaling, full-length Ci is partially degraded by the proteasome to generate a truncated repressor form that translocates to the nucleus to represses Hh-responsive genes. Binding of Hh ligand to the Patched (PTC) receptor allows the 7-pass transmembrane protein Smoothened (SMO) to be activated in an unknown manner, disrupting the partial proteolysis of Ci and allowing the full length activator form to accumulate (reviewed in Ingham et al, 2011; Briscoe and Therond, 2013).
While many of the core components of Hh signaling are conserved from flies to humans, the pathways do show points of significant divergence. Notably, the human genome encodes three Ci homologues, GLI1, 2 and 3 that each play slightly different roles in regulating Hh responsive genes. GLI3 is the primary repressor of Hh signaling in vertebrates, and is converted to the truncated GLI3R repressor form in the absence of Hh. GLI2 is a potent activator of transcription in the presence of Hh but contributes only minimally to the repression function. While a minor fraction of GLI2 protein is processed into the repressor form in the absence of Hh, the majority is either fully degraded by the proteasome or sequestered in the full-length form in the cytosol by protein-protein interactions. GLI1 lacks the repression domain and appears to be an obligate transcriptional activator (reviewed in Briscoe and Therond, 2013).
Vertebrate but not fly Hh signaling also depends on the movement of pathway components through the primary cilium. The primary cilium is a non-motile microtubule based structure whose construction and maintenance depends on intraflagellar transport (IFT). Anterograde IFT moves molecules from the ciliary base along the axoneme to the ciliary tip in a manner that requires the microtubule-plus-end directed kinesin KIF3 motor complex and the IFT-B protein complex, while retrograde IFT back to the ciliary base depends on the minus-end directed dynein motor and the IFT-A complex. Genetic screens have identified a number of cilia-related proteins that are required both to maintain Hh in the 'off' state and to transduce the signal when the pathway is activated (reviewed in Hui and Angers, 2011; Goetz and Anderson, 2010). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 5610787
Reactome version: 66
Reactome Author 
Reactome Author: Rothfels, Karen

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  85. Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV.; ''Hedgehog signalling in the mouse requires intraflagellar transport proteins.''; PubMed Europe PMC
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  92. Weatherbee SD, Niswander LA, Anderson KV.; ''A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling.''; PubMed Europe PMC
  93. Hatayama M, Aruga J.; ''Gli protein nuclear localization signal.''; PubMed Europe PMC
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101477view11:34, 1 November 2018ReactomeTeamreactome version 66
101015view21:14, 31 October 2018ReactomeTeamreactome version 65
100551view19:48, 31 October 2018ReactomeTeamreactome version 64
100099view16:32, 31 October 2018ReactomeTeamreactome version 63
99649view15:04, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99251view12:45, 31 October 2018ReactomeTeamreactome version 62
93840view13:40, 16 August 2017ReactomeTeamreactome version 61
93396view11:22, 9 August 2017ReactomeTeamreactome version 61
87141view18:52, 18 July 2016MkutmonOntology Term : 'Hedgehog signaling pathway' added !
86481view09:19, 11 July 2016ReactomeTeamreactome version 56
83587view07:34, 26 November 2015EgonwAdded missing ENSG parts of the Ensembl IDs.
83062view09:50, 18 November 2015ReactomeTeamVersion54
81377view12:54, 21 August 2015ReactomeTeamNew pathway

External references


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NameTypeDatabase referenceComment
26S proteasomeComplexR-HSA-68819 (Reactome)
4xub-p13S-Gli3:SUFUComplexR-HSA-5610526 (Reactome)
ADCY1 ProteinQ08828 (Uniprot-TrEMBL)
ADCY10 ProteinQ96PN6 (Uniprot-TrEMBL)
ADCY2 ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 ProteinO60266 (Uniprot-TrEMBL)
ADCY4 ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 ProteinO95622 (Uniprot-TrEMBL)
ADCY6 ProteinO43306 (Uniprot-TrEMBL)
ADCY7 ProteinP51828 (Uniprot-TrEMBL)
ADCY8 ProteinP40145 (Uniprot-TrEMBL)
ADCY9 ProteinO60503 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
BTRC:CUL1:RBX1:SKP1ComplexR-HSA-206748 (Reactome)
CSNK1A1ProteinP48729 (Uniprot-TrEMBL)
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
DYNC2H1 ProteinQ8NCM8 (Uniprot-TrEMBL)
FUZ ProteinQ9BT04 (Uniprot-TrEMBL)
G alpha (s):GTPComplexR-HSA-164358 (Reactome)
GLI1 ProteinP08151 (Uniprot-TrEMBL)
GLI1 gene ProteinENSG00000111087 (Ensembl)
GLI1 gene:GLI3RComplexR-HSA-5617398 (Reactome)
GLI1 geneGeneProductENSG00000111087 (Ensembl)
GLI1,2,3ComplexR-HSA-5610616 (Reactome)
GLI1:SUFUComplexR-HSA-5610531 (Reactome)
GLI1ProteinP08151 (Uniprot-TrEMBL)
GLI2 ProteinP10070 (Uniprot-TrEMBL)
GLI2 gene ProteinENSG00000074047 (Ensembl)
GLI2 gene:GLI3RComplexR-HSA-5617399 (Reactome)
GLI2 geneGeneProductENSG00000074047 (Ensembl)
GLI2:SUFUComplexR-HSA-5610536 (Reactome)
GLI2ProteinP10070 (Uniprot-TrEMBL)
GLI3 ProteinP10071 (Uniprot-TrEMBL)
GLI3:SUFUComplexR-HSA-5610542 (Reactome)
GLI3R ProteinP10071 (Uniprot-TrEMBL)
GLI3RProteinP10071 (Uniprot-TrEMBL)
GLI:SUFUComplexR-HSA-5621780 (Reactome)
GLI:SUFUComplexR-HSA-5621783 (Reactome)
GLI:SUFUComplexR-HSA-5621787 (Reactome)
GNAS1 ProteinQ5JWF2 (Uniprot-TrEMBL)
GNAS2 ProteinP63092 (Uniprot-TrEMBL)
GPR161 ProteinQ8N6U8 (Uniprot-TrEMBL)
GPR161:IFT-A:TULP3ComplexR-HSA-5610579 (Reactome)
GPR161ProteinQ8N6U8 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
IFT-A complex:TULP3ComplexR-HSA-5610556 (Reactome)
IFT-A complexComplexR-HSA-5610555 (Reactome)
IFT122 ProteinQ9HBG6 (Uniprot-TrEMBL)
IFT140 ProteinQ96RY7 (Uniprot-TrEMBL)
IFT172 ProteinQ9UG01 (Uniprot-TrEMBL)
IFT52 ProteinQ9Y366 (Uniprot-TrEMBL)
IFT57 ProteinQ9NWB7 (Uniprot-TrEMBL)
IFT88 ProteinQ13099 (Uniprot-TrEMBL)
INTU ProteinQ9ULD6 (Uniprot-TrEMBL)
ITCH ProteinQ96J02 (Uniprot-TrEMBL)
ITCHProteinQ96J02 (Uniprot-TrEMBL)
KIF3A ProteinQ9Y496 (Uniprot-TrEMBL)
KIF7 ProteinQ2M1P5 (Uniprot-TrEMBL)
KIF7:microtubuleComplexR-HSA-5610559 (Reactome)
KIF7ProteinQ2M1P5 (Uniprot-TrEMBL)
MKS1 ProteinQ9NXB0 (Uniprot-TrEMBL)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NUMB ProteinP49757 (Uniprot-TrEMBL)
NUMB:ITCH:ub-pS-GLI1:SUFUComplexR-HSA-5610565 (Reactome)
NUMB:ITCHComplexR-HSA-5610562 (Reactome)
NUMBProteinP49757 (Uniprot-TrEMBL)
OFD1 ProteinO75665 (Uniprot-TrEMBL)
PCP regulators of HhComplexR-HSA-5610624 (Reactome)
PKA catalytic subunitComplexR-HSA-5610569 (Reactome)
PKA regulatory subunits:cAMPComplexR-HSA-5610566 (Reactome)
PKA tetramerComplexR-HSA-5610571 (Reactome)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRKACA ProteinP17612 (Uniprot-TrEMBL)
PRKACB ProteinP22694 (Uniprot-TrEMBL)
PRKACG ProteinP22612 (Uniprot-TrEMBL)
PRKAR1A ProteinP10644 (Uniprot-TrEMBL)
PRKAR1B ProteinP31321 (Uniprot-TrEMBL)
PRKAR2A ProteinP13861 (Uniprot-TrEMBL)
PRKAR2B ProteinP31323 (Uniprot-TrEMBL)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
PTCH1 gene ProteinENSG00000185920 (Ensembl)
PTCH1 gene:GLI3RComplexR-HSA-5612507 (Reactome)
PTCH1 geneGeneProductENSG00000185920 (Ensembl)
PTCH1ProteinQ13635 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RPGRIP1L ProteinQ68CZ1 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SMO ProteinQ99835 (Uniprot-TrEMBL)
SMO dimerComplexR-HSA-5610573 (Reactome)
SMO dimerComplexR-HSA-5610574 (Reactome)
SUFU ProteinQ9UMX1 (Uniprot-TrEMBL)
SUFUProteinQ9UMX1 (Uniprot-TrEMBL)
TTC21B ProteinQ7Z4L5 (Uniprot-TrEMBL)
TULP3 ProteinO75386 (Uniprot-TrEMBL)
TULP3ProteinO75386 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
WDR19 ProteinQ8NEZ3 (Uniprot-TrEMBL)
WDR35 ProteinQ9P2L0 (Uniprot-TrEMBL)
adenylate cyclases:Mg2+ComplexR-HSA-5610577 (Reactome)
anterograde IFT regulators of HhComplexR-HSA-5610625 (Reactome)
cAMP MetaboliteCHEBI:17489 (ChEBI)
cAMPMetaboliteCHEBI:17489 (ChEBI)
ciliary basal body regulators of HhComplexR-HSA-5610628 (Reactome)
microtubule R-HSA-5610520 (Reactome)
microtubuleR-HSA-5610520 (Reactome)
p10S-GLI3 ProteinP10071 (Uniprot-TrEMBL)
p10S-GLI3:SUFUComplexR-HSA-5610581 (Reactome)
p11S-GLI2 ProteinP10070 (Uniprot-TrEMBL)
p11S-GLI2:SUFUComplexR-HSA-5610584 (Reactome)
p13S-GLI3 ProteinP10071 (Uniprot-TrEMBL)
p13S-GLI3:SUFUComplexR-HSA-5610587 (Reactome)
p4S-GLI2 ProteinP10070 (Uniprot-TrEMBL)
p4S-GLI2:SUFUComplexR-HSA-5610589 (Reactome)
p6S-GLI3 ProteinP10071 (Uniprot-TrEMBL)
p6S-GLI3:SUFUComplexR-HSA-5610595 (Reactome)
p8S-GLI2 ProteinP10070 (Uniprot-TrEMBL)
p8S-GLI2:SUFUComplexR-HSA-5610598 (Reactome)
pS-GLI1 ProteinP08151 (Uniprot-TrEMBL)
pS-GLI1:SUFUComplexR-HSA-5610605 (Reactome)
retrograde IFT regulators of HhComplexR-HSA-5610630 (Reactome)
ub-p11S-GLI2 ProteinP10070 (Uniprot-TrEMBL)
ub-p11S-GLI2:SUFUComplexR-HSA-5610608 (Reactome)
ub-p13S-GLI3 ProteinP10071 (Uniprot-TrEMBL)
ub-pS-GLI1 ProteinP08151 (Uniprot-TrEMBL)
ub-pS-GLI1:SUFUComplexR-HSA-5610612 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-5610754 (Reactome)
26S proteasomemim-catalysisR-HSA-5610757 (Reactome)
26S proteasomemim-catalysisR-HSA-5610758 (Reactome)
26S proteasomemim-catalysisR-HSA-5610760 (Reactome)
4xub-p13S-Gli3:SUFUArrowR-HSA-5610746 (Reactome)
4xub-p13S-Gli3:SUFUR-HSA-5610754 (Reactome)
ADPArrowR-HSA-5610717 (Reactome)
ADPArrowR-HSA-5610718 (Reactome)
ADPArrowR-HSA-5610720 (Reactome)
ADPArrowR-HSA-5610722 (Reactome)
ADPArrowR-HSA-5610730 (Reactome)
ADPArrowR-HSA-5610732 (Reactome)
ADPArrowR-HSA-5610741 (Reactome)
ATPR-HSA-5610717 (Reactome)
ATPR-HSA-5610718 (Reactome)
ATPR-HSA-5610720 (Reactome)
ATPR-HSA-5610722 (Reactome)
ATPR-HSA-5610727 (Reactome)
ATPR-HSA-5610730 (Reactome)
ATPR-HSA-5610732 (Reactome)
ATPR-HSA-5610741 (Reactome)
BTRC:CUL1:RBX1:SKP1mim-catalysisR-HSA-5610742 (Reactome)
BTRC:CUL1:RBX1:SKP1mim-catalysisR-HSA-5610745 (Reactome)
BTRC:CUL1:RBX1:SKP1mim-catalysisR-HSA-5610746 (Reactome)
CSNK1A1mim-catalysisR-HSA-5610718 (Reactome)
CSNK1A1mim-catalysisR-HSA-5610722 (Reactome)
G alpha (s):GTPArrowR-HSA-5610727 (Reactome)
GLI1 gene:GLI3RArrowR-HSA-5617408 (Reactome)
GLI1 gene:GLI3RTBarR-HSA-5617412 (Reactome)
GLI1 geneR-HSA-5617408 (Reactome)
GLI1 geneR-HSA-5617412 (Reactome)
GLI1,2,3R-HSA-5610723 (Reactome)
GLI1:SUFUR-HSA-5610741 (Reactome)
GLI1ArrowR-HSA-5617412 (Reactome)
GLI2 gene:GLI3RArrowR-HSA-5617410 (Reactome)
GLI2 gene:GLI3RTBarR-HSA-5617413 (Reactome)
GLI2 geneR-HSA-5617410 (Reactome)
GLI2 geneR-HSA-5617413 (Reactome)
GLI2:SUFUR-HSA-5610717 (Reactome)
GLI2ArrowR-HSA-5617413 (Reactome)
GLI3:SUFUR-HSA-5610720 (Reactome)
GLI3RArrowR-HSA-5610752 (Reactome)
GLI3RArrowR-HSA-5610754 (Reactome)
GLI3RR-HSA-5610752 (Reactome)
GLI3RR-HSA-5612508 (Reactome)
GLI3RR-HSA-5617408 (Reactome)
GLI3RR-HSA-5617410 (Reactome)
GLI:SUFUArrowR-HSA-5610723 (Reactome)
GLI:SUFUArrowR-HSA-5610766 (Reactome)
GLI:SUFUArrowR-HSA-5610767 (Reactome)
GLI:SUFUR-HSA-5610766 (Reactome)
GLI:SUFUR-HSA-5610767 (Reactome)
GPR161:IFT-A:TULP3ArrowR-HSA-5610725 (Reactome)
GPR161:IFT-A:TULP3ArrowR-HSA-5610727 (Reactome)
GPR161R-HSA-5610725 (Reactome)
GSK3Bmim-catalysisR-HSA-5610730 (Reactome)
GSK3Bmim-catalysisR-HSA-5610732 (Reactome)
IFT-A complex:TULP3ArrowR-HSA-5610726 (Reactome)
IFT-A complex:TULP3R-HSA-5610725 (Reactome)
IFT-A complexR-HSA-5610726 (Reactome)
ITCHR-HSA-5610735 (Reactome)
KIF7:microtubuleArrowR-HSA-5610733 (Reactome)
KIF7:microtubuleArrowR-HSA-5610767 (Reactome)
KIF7R-HSA-5610733 (Reactome)
NUMB:ITCH:ub-pS-GLI1:SUFUArrowR-HSA-5610737 (Reactome)
NUMB:ITCH:ub-pS-GLI1:SUFUR-HSA-5610760 (Reactome)
NUMB:ITCHArrowR-HSA-5610735 (Reactome)
NUMB:ITCHArrowR-HSA-5610760 (Reactome)
NUMB:ITCHR-HSA-5610737 (Reactome)
NUMB:ITCHmim-catalysisR-HSA-5610737 (Reactome)
NUMBR-HSA-5610735 (Reactome)
PCP regulators of HhArrowR-HSA-5610766 (Reactome)
PCP regulators of HhArrowR-HSA-5610767 (Reactome)
PKA catalytic subunitArrowR-HSA-5610749 (Reactome)
PKA catalytic subunitmim-catalysisR-HSA-5610717 (Reactome)
PKA catalytic subunitmim-catalysisR-HSA-5610720 (Reactome)
PKA catalytic subunitmim-catalysisR-HSA-5610741 (Reactome)
PKA regulatory subunits:cAMPArrowR-HSA-5610749 (Reactome)
PKA tetramerR-HSA-5610749 (Reactome)
PPiArrowR-HSA-5610727 (Reactome)
PTCH1 gene:GLI3RArrowR-HSA-5612508 (Reactome)
PTCH1 gene:GLI3RTBarR-HSA-5612510 (Reactome)
PTCH1 geneR-HSA-5612508 (Reactome)