EPH-Ephrin signaling (Homo sapiens)

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13, 2718, 496, 4586, 454, 481025, 47, 5030, 32, 3530, 3216395, 448, 122612, 4614, 384083124143, 19, 339, 29, 4325, 4728, 4136151029, 431, 7, 1722, 514816, 522011, 5124345121, 2830, 32, 35, 37cytosolPostsynapticendocytic vesiclePresynapticcytosollate endosome lumenEPHB6 CDC42 Gly p-Y590,Y596-EPHB4 p-Y645,Y651-EPHB6 p-Y397-PTK2 SDCBPARHGEF7 p-Y608,Y614-EPHB3 EFNA1 EPHA2 GDPYES1 p-Y596,Y602-EPHB2 ROCK1 EFNA3 FYN ATPATPp-Y645,Y651-EPHB6 EFNB1 ATPSRC-1 RHOA:GTP:Mg2+EFNA4 EFNA2 (25-?) N-ter EFNA2 (?-188) C-ter ROCK2 EFNB2 Gly YES1 PiEPHB3 p-Y599,Y605-EPHA1 PAK2 EFNB2 EFNB1 p-EPHBs:EFNBs:RASA1EPHA10 p-Y383-GIT1 EFNA5 (?-203) C-ter VAV3 p-Y590,Y596-EPHB4 EFNB1 H2OARPC4 L-Glu FYN EPHB3 (?-?) CLTC EPHB2 SRC-1 p-Y594,Y600-EPHB1 EFNA1 (19-?) N-ter p-2Y-EPHA10 p-2Y-EPHA10 ADPp-Y590,Y596-EPHB4 Gly RHOA:GTP:Mg2+:ROCK1,ROCK2EPHB3 (34-?) VAV2 SRC-1 NCK2 EFNB3 p-Y311,Y316,Y330-EFNB2 p-Y596,Y602-EPHB2 ACTR2 ARPC1A EFNB2 GTP EPHA1 EFNA4 p-T19,S20-MYL12B p-Y608,Y614-EPHA7 p-Y596,Y602-EPHB2 EFNB3 GTP EFNA1(?-182) C-ter GGC-PalmC-RAC1 EPHB6 ITSN1EPHA5 EFNB3 EPHB6 EPHB2 p-Y605,Y611-EPHA6 p-Y596,Y602-EPHB2 RHOA ROCK1 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTPEFNA3 p-Y608,Y614-EPHB3 HRAS p-Y594,Y600-EPHB1 GIT1EPHB N-terminalfragmentsYES1 p-Y318,Y323,Y337-EFNB3 EFNB3 EFNB2 p-Y650,Y656-EPHA5 EPHAsp-Y596,Y602-EPHA4 p-Y645,Y651-EPHB6 EFNB2 EFNA4 pS-SHB EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4YES1 EFNB1 GRIN1 p-Y610,Y616-EPHA8 ACTG1 FYN RAC1:GTPGTP p-Y645,Y651-EPHB6 ADPp-Y650,Y656-EPHA5 CLTC EPHA4 EFNA3 p-Y608,Y614-EPHB3 SDCBP EFNA4 p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2CLTA EFNB3 p-Y645,Y651-EPHB6 EFNB2 p-Y311,Y316,Y330-EFNB2 ARPC1B RHOA EPHB2 EFNB3 p-Y608,Y614-EPHB3 p-Y590,Y596-EPHB4 p-Y645,Y651-EPHB6 p-Y594,Y600-EPHB1 p-Y608,Y614-EPHB3 GTP EPHA3 EPHB6 (?-1021) GTP p-Y383-GIT1 EFNA2 RAC1-GTP:p-S144,T423-PAK1SRC-1 TIAM1 NCK2 EPHB2 EFNA3 p-Y590,Y596-EPHB4 p-Y590,Y596-EPHB4 RHOA p-Y596,Y602-EPHA3 ADPp-Y324,Y329,Y343-EFNB1 EPHA3 EPHB1 EFNB2 p-Y594,Y600-EPHB1 EFNBs:p-EPHBs:p-Y397-FAK:p190RhoGEF:Rho (Mg cofactor):GTP:Activated ROCKEPHB1 ACTB(1-375) EPHA10 p-Y608,Y614-EPHB3 p-Y397-PTK2 EPHB6 p-2Y-EPHA10 EFNB1 ROCK2 GTP PAK3 EFNA5 (21-?) N-ter Glu:NMDAR:Glyp-S19-MYL12AAP2A1 EPHB4 p-Y594,Y600-EPHB1 EFNA4 FYN EPHB2 (19-?) p-Y596,Y602-EPHB2 GTPGTP p-Y650,Y656-EPHA5 p-Y318,Y323,Y337-EFNB3 YES1 p-Y608,Y614-EPHB3 MMP9 RAC1:GTP:PAK1dimer:RAC1:GTPGGC-PalmC-RAC1 APH1A EFNB1 p-Y383-GIT1 Ras:GTPEFNB3 EFNA1 p-Y311,Y316,Y330-EFNB2 N-WASP EPHB CTF1EPHB1 ADPSRC-1 p-S141,T402-PAK2 EFNB2 EFNA4 p-Y605,Y611-EPHA6 NCK2ATPYES1 p-Y596,Y602-EPHB2 GTP EFNA4 YES1 EPHA4 ACTR3 RAC1:GDPGTPp-Y608,Y614-EPHB3 EPHB1 GDPp-Y588,Y594-EPHA2 EFNB1 p-Y605,Y611-EPHA6 p-Y608,Y614-EPHA7 p-Y645,Y651-EPHB6 EFNA1 GGC-PalmC-RAC1 EFNBs:p-EPHBs:p-Y397-FAKp-Y594,Y600-EPHB1 L-Glu SRC-1 HSP90AA1 EPHB3 p-Y596,Y602-EPHA4 EFNA5 ATPp-Y590,Y596-EPHB4 EPHB6 VAV2 p190RhoGEF EFNA5 ADPEPHA5 Smoothmuscle/non-musclemyosin IIp-Y610,Y616-EPHA8 EFNB3 FYN p-Y594,Y600-EPHB1 CDC42:GDPGRIN1 EFNB2 EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2, VAV3:RAC1-GTPMMP2, MMP9p-Y829-TIAM1 p-Y588,Y594-EPHA2 RhoA (Mgcofactor):GDPLYN EPHAs:EFNAsFYN ATPAP2B1 p-Y645,Y651-EPHB6 ATPGDPp-EPHAs/p-EPHBs:EFNAs/EFNBsp-Y608,Y614-EPHB3 p-Y645,Y651-EPHB6 p-Y596,Y602-EPHA4 EFNB3 p-Y594,Y600-EPHB1 p-Y383-GIT1 GTP DNM1EPHB2 (?-?) EFNB2 ADPEFNB3 EPHB2 (?-1055) EFNA2 EPHB6 EPHB4 (16-?) EPHB3 EFNB3 PI(4,5)P2LYN GGC-PalmC-RAC1 TIAM1 EFNA4 ADPp-Y318,Y323,Y337-EFNB3 EFNB2 p-Y594,Y600-EPHB1 ATPp-Y608,Y614-EPHA7 EFNB3 p-Y596,Y602-EPHB2 p-Y599,Y605-EPHA1 SRC-1 p-Y645,Y651-EPHB6 N-WASP EFNB3 p-Y590,Y596-EPHB4 LIMK1 EFNA2 ADPp-Y596,Y602-EPHB2 EPHA6 PAK1 dimerp-Y588,Y594-EPHA2 p-Y594,Y600-EPHB1 EFNB1 RAC1:GDPEPHB2 EFNB1 p-Y596,Y602-EPHB2 GTPLYN CLTA EPHA4 SRC-1 EFNB2 EFNAs:p-EPHAs:SFKs:NGEFp-Y324,Y329,Y343-EFNB1 EFNA5 EPHA2 EPHB CTF2EPHB4 EPHB4 EFNB3 p-Y397-PTK2 ACTR3 EPHB1 RHOA p-Y588,Y594-EPHA2 p-Y645,Y651-EPHB6 p-Y605,Y611-EPHA6 MYL9 EFNA1 FYN p-Y590,Y596-EPHB4 p-Y608,Y614-EPHB3 p-6Y-VEGFR2 p-Y650,Y656-EPHA5 EFNB1 LYN EPHA8 p-Y590,Y596-EPHB4 RAC1:GDPp-Y590,Y596-EPHB4 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3EFNB1 EFNA5 ADPp-Y590,Y596-EPHB4 Mg2+ p-Y596,Y602-EPHA3 RHOA:GTP:Mg2+:Activated ROCK1,ROCK2p-Y645,Y651-EPHB6 GTPGRIN1 EFNA3 (?-214) C-ter AP2M1 EFNB1 p-Y608,Y614-EPHB3 SRC-1 ATP EPHB4 SRC-1 EFNB3 p-Y608,Y614-EPHB3 p-Y610,Y616-EPHA8 p-Y605,Y611-EPHA6 RASA1EFNAs:p-EPHAs:SFKs:p-Y179-NGEFEPHA1 EFNA4 p-Y599,Y605-EPHA1 SRC-1 p-EPHBs:EFNBsp-Y596,Y602-EPHB2 p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actinADPEFNB3 CLTB CFL1EFNA2 p-Y383-GIT1EFNA2 EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1ARHGEF7 p-Y1252,Y1336,Y1474-GRIN2B p-Y608,Y614-EPHA7 EPHA10 p-Y397-PTK2 EPHA3 p-Y318,Y323,Y337-EFNB3 CDC42 FYN p-Y594,Y600-EPHB1 EFNA3 (23-?) N-ter SDC2EFNBs:p-EPHBs:p-Y397-FAK:p190RhoGEFEFNA5 EPHB3 p-Y645,Y651-EPHB6 ATPEFNBs:p-EPHBs:KALRNRAC1:GTPp-T505-LIMK2 EFNB3 ADPp-Y608,Y614-EPHA7 EFNB1 SRC-1 p-Y645,Y651-EPHB6 EPHB6 EFNB3 EFNA3 EPHB1 p-Y610,Y616-EPHA8 EFNB3 EFNA N-terminalfragmentsEPHB2 Mg2+ p-EPH:ephrinoligomersp-Y608,Y614-EPHB3 EPHB6 LYN YES1 YES1 p-Y590,Y596-EPHB4 EFNA2 p-Y590,Y596-EPHB4 RHOA EPHA6 EPHB6 p-Y596,Y602-EPHB2 VAV3 LYN EFNB2 p-Y599,Y605-EPHA1 EFNB1 EFNB1 p-Y596,Y602-EPHA4 EFNA5 EPHA/B:EFNA/B dimersp-EPHBs:EFNBs:RASA1:Ras:GTPEFNA2 ATPNCK2 p-Y596,Y602-EPHB2 ROCK1 p-Y650,Y656-EPHA5 G-actinEPHB6 (?-1021) GGC-PalmC-RAC1 p-Y608,Y614-EPHA7 p-Y596,Y602-EPHA3 FYN YES1 p-Y590,Y596-EPHB4 EPHB1 EFNB2 RHOA p-Y596,Y602-EPHB2 EPHBsGly p-S3-CFL1:p-LIMKGDPSRC-1 EFNB2 EPHA1 EFNB1 p-Y594,Y600-EPHB1 EFNA2 EFNB2 EPHB3 LIM Kinasesp-Y588,Y594-EPHA2 EFNB1 p190RhoGEF ARPC5 EFNB3 KALRN PI(4,5)P2 p-Y608,Y614-EPHB3 p-Y594,Y600-EPHB1 FYN EPHB1 ACTB(1-375) EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3EFNAsEPHA2 AP2S1 EFNB2 EPHA8 PAK1 ATPAP2M1 FYN GDP EFNB1 p-Y596,Y602-EPHA3 p-Y179,Y191-SDC2clusterp-T508-LIMK1 EPHA8 p-Y645,Y651-EPHB6 PSEN2(1-297) EPHA2 EFNAs:p-EPHAs:SRC,FYN,YES,LYN/EFNBs:p-EPHBs:SRC,FYN,YES,LYNEFNB3 p-Y596,Y602-EPHA4 p-Y594,Y600-EPHB1 PSENEN p-Y594,Y600-EPHB1 EPHB4 p-T19,S20-MRLC-smooth muscle/non-muscle myosin IISRC-1 EPHB6 EFNBsPAK3 ADPRHOA:GDP:Mg2+p-Y605,Y611-EPHA6 ADPp-Y610,Y616-EPHA8 p-Y608,Y614-EPHB3 p-Y645,Y651-EPHB6 SRC,FYN,YES,LYNEFNA4 ITSN1 EPHA1 p-Y311,Y316,Y330-EFNB2 GRIN1 GRIN1 EFNA5 p-Y596,Y602-EPHB2 EPHA7 MYL12B EPHA6 EPHB4 (?-987) MYH11 p-Y608,Y614-EPHA7 p-Y324,Y329,Y343-EFNB1 EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1EFNA5 AP2B1 p-S144,T423-PAK1 Mg2+ p-Y610,Y616-EPHA8 EFNA3 EFNB2 NGEF p-Y311,Y316,Y330-EFNB2 ARP2/3 complex (ATPbound)EPHB6 (?-?) p-Y599,Y605-EPHA1 p-EPHBs:EFNBs:RASA1:Ras:GDPEPHB3 (?-998) EPHA4 p-Y596,Y602-EPHA4 EPHA8 GDP EFNA C-terminalfragmentsEPHB2 GGC-PalmC-RAC1 LIMK2 ATPp-Y610,Y616-EPHA8 EPHA6 ATPARPC4 EFNB2 EPHB3 CAV1EPHA7 p-Y1252,Y1336,Y1474-GRIN2B p-Y608,Y614-EPHB3 p190RhoGEFEPHA8 GGC-PalmC-RAC1 RAC1 SRC,FYNp-Y588,Y594-EPHA2 EFNA2 LYN EPHB3 FYN p-Y324,Y329,Y343-EFNB1 GDP MYH9 GGC-PalmC-RAC1 p190RhoGEF VAV2 GDPCDC42 MYL6 EFNB2 EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynaminp-T19,S20-MYL9 EPHB3 ROCK1 EPHB2 EFNA5 EFNB2 p-Y608,Y614-EPHB3 EFNB1 GTP ARPC5 EPHB2 VEGFA-165 EPHB1 (?-984) EPHB2 EPHB4 APH1B EFNA5 EFNB3 ARPC2 SRC-1 EPHB1 EFNA2 VAV3 EPHB1 (?-984) p-2Y-EPHA10 EFNA3 p-Y599,Y605-EPHA1 EPHB3 (?-998) GDP EPHA5 ATPRAC1 SRC-1 EPHB4 (?-987) EFNB1 p-Y608,Y614-EPHB3 EPHA2 ATP p-Y596,Y602-EPHB2 p-Y590,Y596-EPHB4 p-Y594,Y600-EPHB1 RAC1:GDPAP2A1 p-LIMKp-Y596,Y602-EPHA4 EFNA5 EPHA5 p-Y596,Y602-EPHA3 SRC-1 FYN FYN p-Y594,Y600-EPHB1 EFNA2 GTPEPHA6 RHOA EPHB4 LYN EPHA7 EPHB2 FYN EFNA3 p-Y599,Y605-EPHA1 p-2Y-EPHA10 p-S144,T423-PAK1 p-Y590,Y596-EPHB4 p-Y608,Y614-EPHB3 EFNA4 (?-170) C-ter p-Y311,Y316,Y330-EFNB2 RAC1 FYN EPHB6 p-Y588,Y594-EPHA2 ATPp-Y596,Y602-EPHA3 p-Y596,Y602-EPHB2 KALRNEPHB3 EFNB3 p-Y645,Y651-EPHB6 N-WASPp-2Y-EPHA10 CLTCL1 NCK2 RASA1 EFNB1 SRC-1 AP2A2(1-939) EFNAs:p-EPHAs:SFKs:TIAM1EPHB1 YES1 ACTG1 NCSTN ARPC3 p-Y596,Y602-EPHB2 p-Y645,Y651-EPHB6 NCK2 EPHB C-terminalfragments (CTF)EPHB4 (?-?) EFNA4 YES1 EFNA3 ITSN1 EPHA3 p-Y610,Y616-EPHA8 ADAM10 p-Y179-NGEF ARHGEF7 p-Y645,Y651-EPHB6 MYH9 EFNB1 EFNB1 EFNB2 EPHA5 EFNB1 EFNB1 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7EFNB3 RASA1 p-Y605,Y611-EPHA6 p-Y590,Y596-EPHB4 p-Y596,Y602-EPHA3 VAV2,VAV3p-Y172-VAV2 GTPp-Y650,Y656-EPHA5 p-Y594,Y600-EPHB1 DNM1 PAK1 EFNB1 MYH10 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-FAK1:SRC-1:HSP90AA1EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3p-Y650,Y656-EPHA5 FAK1 FAK1p-Y605,Y611-EPHA6 SRC-1 GTP ARPC3 p-Y608,Y614-EPHA7 EPHB6 EFNB2 SRC-1 EPHB1 FYN p-Y608,Y614-EPHB3 EFNB2 p-Y596,Y602-EPHA4 EPHBs:EFNBs:SRC,FYNp-Y173-VAV3 EPHB3 EFNBs:p-EPHBs:SFKs:Glu:NMDAR:GlyEFNA5 LYN Activated ROCK2 GDPp-Y179,Y191-SDC2p-Y596,Y602-EPHA3 Mg2+ p-Y594,Y600-EPHB1 p-Y596,Y602-EPHB2 EFNB2 EFNA3 NGEFEPH-EFN tetramerSRC-1 p-Y594,Y600-EPHB1 Mg2+ p-Y599,Y605-EPHA1 EFNA1 p-Y318,Y323,Y337-EFNB3 EFNA1 GRIN2B EPHB2 (?-1055) PAK2 EFNA1 p-Y588,Y594-EPHA2 EFNA4 ADPClathrinEPHB2 EPHB4 EFNA3 FYN p-Y594,Y600-EPHB1 p-2Y-EPHA10 EFNA1 p-Y596,Y602-EPHB2 NCK2 PAK1 EPHA7 SRC-1 EFNAs:p-EPHAs:SFKsRAC1 ACTR2 EFNB2 FYN ROCK2 p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTPp-Y610,Y616-EPHA8 N-WASP EFNA5 p-Y590,Y596-EPHB4 EFNB2 EFNB1 EFNB3 p-Y594,Y600-EPHB1 EPHB4 p-Y650,Y656-EPHA5 EFNB1 ITSN1 EPHA10 GDP p-EPHBs:EFNBs:ITSN1EFNA3 EFNB3 EFNB1 CLTCL1 GTPHRAS p-T508-LIMK1 Activated ROCK1 EFNA3 p-T505-LIMK2 EPHAs:EFNAs:ADAM10EPHB4 EPHA4 EFNB2 p-Y645,Y651-EPHB6 EFNB3 p-Y608,Y614-EPHB3 GTP EPHB3 p-2Y-EPHA10 EFNA1 ATP N-WASP EPHB4 EPHB4 EFNB2 GDP EFNB3 ARPC1A EPHA7 ARHGEF7FYN EPHA3 p-Y605,Y611-EPHA6 GDP p-Y590,Y596-EPHB4 EPHB1 MYH11 EPHBs:p-3Y-EFNBs:SRC,FYNp-5Y-FAK1 EFNB3 EPHB6 (32-?) p-Y596,Y602-EPHB2 GTP EPHB3 EFNA4 (26-?) N-ter p-Y596,Y602-EPHA4 p-Y594,Y600-EPHB1 MYL6 PAK1 EFNB2 AP2A2(1-939) EFNA2 MYH14 GTP p-Y588,Y594-EPHA2 EPHA10 EFNBs:p-EPHBs:p-Y397-FAK:p190RhoGEF:Rho (Mg cofactor):GTPSRC-1 FYN LYN p-Y645,Y651-EPHB6 LYN GTP EFNB1 p-Y590,Y596-EPHB4 p-2Y-EPHA10 CLTB EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1EPH-ephrin oligomersEPHB1 GTP p-Y596,Y602-EPHB2 MYH14 EFNA1 EPHB6 p-Y608,Y614-EPHB3 p-Y596,Y602-EPHA3 HRAS p-EPHBs:EFNBs:ITSN1:N-WASPp-Y590,Y596-EPHB4 f-actin EFNA1 CDC42 p-Y318,Y323,Y337-EFNB3 EPHBs:EFNBsEPHA1 EPHB3 p-Y590,Y596-EPHB4 AP-2 Complexp-S154,T436-PAK3 p-Y608,Y614-EPHB3 ITSN1 p-Y590,Y596-EPHB4 EFNA2 EFNB3 FYN gamma-secretasecomplexROCK2 EFNA5 LYN ADPEFNA1 p-Y383-GIT1 EPHB2 ARPC1B p-Y645,Y651-EPHB6 EFNA3 EPHB4 TIAM1p-Y311,Y316,Y330-EFNB2 PAK1/3, 2EPHBs:EFNBs:SDCBPEFNB2 EFNB3 p-Y596,Y602-EPHB2 SRC-1 RASA1 EPHB4 p-S3-CFL1 ITSN1 p-Y645,Y651-EPHB6 p-Y590,Y596-EPHB4 L-Glu p-Y645,Y651-EPHB6 p-Y1252,Y1336,Y1474-GRIN2B EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:GlyEFNB3 p-Y599,Y605-EPHA1 EFNB1 EFNB2 MMP2(110-660) p-Y318,Y323,Y337-EFNB3 MYH10 f-actinGly GTP YES1 GDPGTP Mg2+ L-Glu EPHB1 EFNBs:p-EPHBs:SFKsLYN EFNA4 p-Y324,Y329,Y343-EFNB1 EPHB2 MYL12Ap-Y594,Y600-EPHB1 EPHB1 (?-?) LYN EFNA4 p-Y608,Y614-EPHB3 GRIN2B p-Y608,Y614-EPHB3 EFNA1 p-Y608,Y614-EPHA7 ROCK1,ROCK2p-Y594,Y600-EPHB1 Mg2+ EPHB1 (18-?) p-Y596,Y602-EPHB2 p-Y650,Y656-EPHA5 EFNA1 p-Y645,Y651-EPHB6 EFNB1 GDP ARHGEF7 PI(4,5)P2 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3L-Glu FYN YES1 p-Y324,Y329,Y343-EFNB1 EPHB6 AP2S1 p-Y596,Y602-EPHB2 ARPC2 ADAM10p-Y324,Y329,Y343-EFNB1 ROCK1,ROCK2EFNA2 EPHB3 EFNBs:p-EPHBs:FAKp-Y596,Y602-EPHB2 23, 42223, 4223, 4223, 4223, 4223, 4223, 4223, 42