EPH-Ephrin signaling (Homo sapiens)

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13, 273429, 4325, 4728, 41105, 4411, 511412, 461, 7, 1725, 47, 502010488, 1230, 323914, 38368246, 4518, 4931815406, 4530, 32, 3522, 514, 483, 19, 3351162421, 2830, 32, 35, 372616, 529, 29, 43endocytic vesiclePresynapticlate endosome lumenPostsynapticcytosolcytosolEPHB2 p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2GRIN1 EFNB1 p-Y594,Y600-EPHB1 p-Y596,Y602-EPHB2 MYL12APAK3 p-Y590,Y596-EPHB4 p-Y610,Y616-EPHA8 EFNA4 RAC1 EFNA5 EFNB3 ROCK1 EFNAsATPEPHB6 DNM1 p-Y594,Y600-EPHB1 p-Y608,Y614-EPHA7 p-T508-LIMK1 EFNA4 GDP EFNA1 EFNA5 (?-203) C-ter ADAM10ROCK2 EFNBs:p-EPHBs:p-Y397-FAK:p190RhoGEF:Rho (Mg cofactor):GTP:Activated ROCKp-T505-LIMK2 SRC,FYN,YES,LYNSRC-1 EPHBsp-Y588,Y594-EPHA2 PAK1/3, 2ITSN1ATPGTPp-Y179,Y191-SDC2p-Y318,Y323,Y337-EFNB3 EFNA2 (?-188) C-ter NCSTN EFNB1 FAK1p-5Y-FAK1 ARPC1A p-T508-LIMK1 ADPEPHB CTF1AP2M1 FYN EFNB2 EFNB2 EFNA4 (?-170) C-ter SRC-1 EFNA3 f-actin EFNB1 p-Y608,Y614-EPHB3 ROCK1,ROCK2EPHB N-terminalfragmentsp-Y596,Y602-EPHB2 p-Y383-GIT1p-Y311,Y316,Y330-EFNB2 p190RhoGEF EPHB3 EFNB3 ARPC5 p-Y608,Y614-EPHB3 p-EPHBs:EFNBs:RASA1GTP EPHA6 EFNA1 MYH9 H2Op-Y596,Y602-EPHA4 EFNB3 N-WASP RHOA EFNA5 PAK1 EPHB2 p-T19,S20-MYL12B EPHA2 FAK1 EPHB2 EFNB2 p-Y596,Y602-EPHA3 EFNB3 ROCK1 RHOA p-Y324,Y329,Y343-EFNB1 EPHA/B:EFNA/B dimersp-Y590,Y596-EPHB4 HRAS YES1 p-Y324,Y329,Y343-EFNB1 EFNA3 (23-?) N-ter EFNA5 EPHB4 p-Y650,Y656-EPHA5 p-Y610,Y616-EPHA8 p-Y605,Y611-EPHA6 p-2Y-EPHA10 p-Y594,Y600-EPHB1 EFNBs:p-EPHBs:p-Y397-FAK:p190RhoGEFEFNA1 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-FAK1:SRC-1:HSP90AA1p-Y318,Y323,Y337-EFNB3 EFNAs:p-EPHAs:SRC,FYN,YES,LYN/EFNBs:p-EPHBs:SRC,FYN,YES,LYNp-Y608,Y614-EPHA7 p-Y596,Y602-EPHB2 p-Y599,Y605-EPHA1 ARPC1B ATPRAC1:GDPGDP p-Y594,Y600-EPHB1 LIMK1 p-Y605,Y611-EPHA6 AP2S1 EPHA10 LYN p-Y590,Y596-EPHB4 EPHB3 EFNA1 GTPAP2S1 N-WASP p-Y594,Y600-EPHB1 EFNBs:p-EPHBs:FAKEPHB3 ACTR3 p-Y645,Y651-EPHB6 EFNB2 EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynaminp-Y590,Y596-EPHB4 EFNB1 p-Y594,Y600-EPHB1 EFNB2 p-Y590,Y596-EPHB4 p-Y324,Y329,Y343-EFNB1 EPHB2 (?-1055) p-Y397-PTK2 p-Y318,Y323,Y337-EFNB3 p-Y645,Y651-EPHB6 PAK1 ADPp-Y1252,Y1336,Y1474-GRIN2B p-Y311,Y316,Y330-EFNB2 EFNB2 ADAM10 EFNB1 SRC-1 RHOA:GDP:Mg2+LYN p-Y608,Y614-EPHB3 EPHB6 EFNA5 EFNB1 TIAM1EFNB2 GTP ARHGEF7 ACTR2 p-Y590,Y596-EPHB4 p-Y596,Y602-EPHB2 EPHB2 EFNA3 ADPGTP Gly GDPEFNA2 (25-?) N-ter p-S3-CFL1 ADPEPH-ephrin oligomersEPHB1 EFNB2 EFNA1 ARHGEF7EFNA5 (21-?) N-ter EFNB3 p-Y596,Y602-EPHB2 ACTB(1-375) p-Y605,Y611-EPHA6 EPHB4 EFNB3 p-Y590,Y596-EPHB4 EPHB4 (?-987) GDPNCK2 PSEN2(1-297) GDP p-Y318,Y323,Y337-EFNB3 p-Y596,Y602-EPHB2 p-EPHBs:EFNBsEPHA8 EPHB3 GTP MMP2, MMP9EFNB1 Gly EFNB2 GGC-PalmC-RAC1 EPHB6 EFNA1 p-Y596,Y602-EPHA3 p-Y311,Y316,Y330-EFNB2 p-Y318,Y323,Y337-EFNB3 EFNB3 EFNB3 PAK1 dimerEFNA1 NGEF EPHA10 ARPC3 p-Y383-GIT1 p-Y596,Y602-EPHB2 p-Y590,Y596-EPHB4 EFNB1 RHOA EFNA4 p-EPHBs:EFNBs:ITSN1:N-WASPp-Y596,Y602-EPHA3 p-Y596,Y602-EPHA4 p-Y594,Y600-EPHB1 ATPGGC-PalmC-RAC1 p-Y645,Y651-EPHB6 YES1 p-Y645,Y651-EPHB6 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTPpS-SHB EFNB3 p-2Y-EPHA10 EFNA2 p-Y608,Y614-EPHA7 EFNB1 EPHB2 APH1A Mg2+ EFNA2 VAV2 EPHA2 Mg2+ p-Y599,Y605-EPHA1 EPHBs:EFNBsp-Y324,Y329,Y343-EFNB1 EFNB2 p-Y596,Y602-EPHB2 p-Y645,Y651-EPHB6 p-Y610,Y616-EPHA8 p-Y645,Y651-EPHB6 EPHB3 (?-998) p-Y1252,Y1336,Y1474-GRIN2B EFNA4 p-Y608,Y614-EPHB3 FYN EFNA3 EFNB1 LIM KinasesEPHB6 p-Y594,Y600-EPHB1 L-Glu p-Y608,Y614-EPHB3 p-Y596,Y602-EPHB2 p-Y590,Y596-EPHB4 p-Y594,Y600-EPHB1 p-2Y-EPHA10 p-Y650,Y656-EPHA5 EFNB2 p-Y318,Y323,Y337-EFNB3 ATPCLTA MMP2(110-660) EFNBs:p-EPHBs:p-Y397-FAK:p190RhoGEF:Rho (Mg cofactor):GTPFYN EPHBs:EFNBs:SRC,FYNEPHB6 (?-?) p-Y650,Y656-EPHA5 EPHB2 EPHB1 (18-?) EFNB3 p-Y650,Y656-EPHA5 p-Y645,Y651-EPHB6 FYN GGC-PalmC-RAC1 RAC1 EFNA1 RASA1 EPHB4 p-Y610,Y616-EPHA8 EFNB2 PAK1 p-Y596,Y602-EPHA4 EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1LYN p-Y588,Y594-EPHA2 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7p-Y594,Y600-EPHB1 GTP EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:GlyEFNB1 ROCK1 EPHB6 p-S144,T423-PAK1 LYN EPHA3 GTP YES1 YES1 GRIN1 RAC1:GTPFYN p-Y645,Y651-EPHB6 EFNB3 VAV3 FYN ClathrinEPHA10 EFNA4 EPHA8 p-Y608,Y614-EPHA7 EPHB6 EFNA2 EPHB3 (?-?) EPHB1 EPHB1 EFNBs:p-EPHBs:p-Y397-FAKp-Y596,Y602-EPHB2 ARPC3 EFNB1 Mg2+ EFNA4 p-Y594,Y600-EPHB1 p-Y596,Y602-EPHA3 MYH9 p-Y645,Y651-EPHB6 p-Y610,Y616-EPHA8 EFNB1 p-Y590,Y596-EPHB4 Activated ROCK2 p-Y605,Y611-EPHA6 p190RhoGEFFYN EPHA5 EFNB1 RAC1 SRC-1 PAK3 p-Y608,Y614-EPHA7 EFNA2 MYL6 SRC-1 p-Y397-PTK2 EFNA5 EPHB4 p-Y594,Y600-EPHB1 RHOA Glu:NMDAR:GlyEFNA C-terminalfragmentsAP2A2(1-939) CDC42 p-Y590,Y596-EPHB4 p-6Y-VEGFR2 ARPC4 EPHB1 VAV3 EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1p-Y590,Y596-EPHB4 p-Y599,Y605-EPHA1 p-Y596,Y602-EPHA3 GDP p-Y650,Y656-EPHA5 EPHA6 EFNA1 p-Y588,Y594-EPHA2 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3p-T19,S20-MYL9 EFNB3 ACTB(1-375) GGC-PalmC-RAC1 p190RhoGEF CLTCL1 p-LIMKEFNA5 ATPEPHA1 L-Glu PAK2 p-Y608,Y614-EPHB3 p-Y596,Y602-EPHA4 EFNA3 p-Y596,Y602-EPHB2 EFNA5 EPHB4 CDC42 EFNA3 EFNB2 EFNA N-terminalfragmentsHRAS p-Y645,Y651-EPHB6 EFNA2 EFNB3 p-Y594,Y600-EPHB1 p-S154,T436-PAK3 p-Y596,Y602-EPHB2 L-Glu ADPRASA1 p-T505-LIMK2 p-Y596,Y602-EPHA4 GTP NCK2p-Y594,Y600-EPHB1 EPHB2 EPHA1 EPH-EFN tetramerEPHBs:p-3Y-EFNBs:SRC,FYN:GRB4p-Y599,Y605-EPHA1 EFNBs:p-EPHBs:SFKsEFNA3 (?-214) C-ter EFNB2 p-Y645,Y651-EPHB6 CAV1p-Y590,Y596-EPHB4 EPHB2 HSP90AA1 FYN EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3EFNB1 YES1 EFNB1 p-Y608,Y614-EPHB3 EPHA3 EPHB2 EFNB3 p-Y608,Y614-EPHB3 FYN ADPp-Y588,Y594-EPHA2 p-Y608,Y614-EPHA7 p-Y608,Y614-EPHB3 p-2Y-EPHA10 EFNA2 EPHB3 Ras:GTPYES1 GDP p-Y311,Y316,Y330-EFNB2 KALRN RHOA p-Y605,Y611-EPHA6 ATP EPHB2 (?-1055) NCK2 p-Y596,Y602-EPHA4 EFNA5 EFNB1 EFNB3 SRC-1 EFNB1 KALRNEPHB6 EFNB3 EFNB1 GRIN1 CFL1GTP EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3PiGRIN2B EPHA6 FYN EFNB2 YES1 EPHA8 SRC-1 ROCK1,ROCK2EFNA4 f-actinp-Y397-PTK2 ARPC2 p-Y650,Y656-EPHA5 EFNB1 ARPC1B p-Y590,Y596-EPHB4 EFNB2 VAV2 EPHBs:p-3Y-EFNBs:SRC,FYNATP VAV2,VAV3EPHA7 p-Y179,Y191-SDC2clusterAP2A1 EPHA1 EPHA5 p-Y383-GIT1 Gly AP2A2(1-939) EFNA3 p-Y650,Y656-EPHA5 EPHA8 EFNA5 SDC2ADPEPHA5 p-Y594,Y600-EPHB1 EPHB4 (?-987) EFNA4 SRC-1 RASA1 p-2Y-EPHA10 EFNB2 EPHB6 (?-1021) EFNB2 EPHB1 MYL9 p-Y650,Y656-EPHA5 EPHB2 EPHA7 GTP ATPp-Y610,Y616-EPHA8 p-Y596,Y602-EPHA3 NCK2 p-Y599,Y605-EPHA1 p-Y590,Y596-EPHB4 p-Y594,Y600-EPHB1 ATPEFNA1 p-Y608,Y614-EPHB3 EPHA6 EPHB3 p-Y596,Y602-EPHB2 p-Y596,Y602-EPHB2 EFNA2 EFNB3 EPHA4 MYH11 EPHA3 EPHB1 (?-984) MYH10 p-Y596,Y602-EPHA4 EPHB6 TIAM1 EFNA2 AP-2 ComplexRAC1-GTP:p-S144,T423-PAK1p-Y179-NGEF p-Y599,Y605-EPHA1 EFNAs:p-EPHAs:SFKsADPEFNA3 EPHB3 p-Y596,Y602-EPHB2 EPHB2 (?-?) p-Y588,Y594-EPHA2 p-Y608,Y614-EPHB3 EPHB CTF2EPHA10 p-2Y-EPHA10 EPHA5 p-Y608,Y614-EPHB3 EFNA4 FYN GTPROCK2 MYL6 p-Y599,Y605-EPHA1 EPHA3 p-Y645,Y651-EPHB6 ARPC1A ITSN1 SRC-1 CLTB EPHA4 p-Y608,Y614-EPHB3 p-Y590,Y596-EPHB4 p-Y608,Y614-EPHB3 EPHA5 ADPVAV2 p-Y608,Y614-EPHA7 YES1 EPHB6 FYN SRC-1 EPHAsp-Y172-VAV2 EPHB6 p-Y596,Y602-EPHB2 p-T19,S20-MRLC-smooth muscle/non-muscle myosin IINCK2 GTPp-Y596,Y602-EPHB2 RAC1:GTPp-Y645,Y651-EPHB6 MYH14 ITSN1 CLTB MYH11 SRC-1 GDPEFNB2 EFNA2 ITSN1 p-Y590,Y596-EPHB4 CDC42 ROCK2 ARPC2 FYN Activated ROCK1 EPHB4 (16-?) EFNB2 EPHB1 gamma-secretasecomplexEFNA2 p-Y650,Y656-EPHA5 ATP ADPARHGEF7 NGEFp-Y608,Y614-EPHB3 EPHB4 (?-?) SRC-1 EFNAs:p-EPHAs:SFKs:p-Y179-NGEFp-Y588,Y594-EPHA2 EPHB C-terminalfragments (CTF)GTP EPHA2 p-Y596,Y602-EPHB2 GTP EFNB2 EPHB1 (?-984) ATPp-Y590,Y596-EPHB4 EFNA4 ARPC4 EFNB3 EFNB1 YES1 p-Y608,Y614-EPHB3 EPHB4 LIMK2 p-2Y-EPHA10 EFNA2 EPHA2 LYN p-EPH:ephrinoligomersEFNA4 EFNB1 EFNB2 ADPRAC1:GDPEPHA3 p-Y608,Y614-EPHB3 EPHB1 FYN EPHA4 FYN PAK2 EPHAs:EFNAsp-Y588,Y594-EPHA2 EFNA3 p-Y383-GIT1 EFNB2 p-Y590,Y596-EPHB4 EFNA1(?-182) C-ter EPHB3 p-Y829-TIAM1 EPHB3 EPHB2 YES1 GTP EFNA5 LYN p-Y596,Y602-EPHB2 EFNB3 p-EPHBs:EFNBs:RASA1:Ras:GDPp-Y594,Y600-EPHB1 p-Y596,Y602-EPHB2 EFNA3 AP2M1 p-Y311,Y316,Y330-EFNB2 p-EPHBs:EFNBs:RASA1:Ras:GTPATPEFNB2 EPHB6 RAC1:GDPARHGEF7 EFNB3 ACTR2 PSENEN ARP2/3 complex (ATPbound)EFNB3 p-Y594,Y600-EPHB1 p-Y311,Y316,Y330-EFNB2 EPHB3 (34-?) EPHB1 (?-?) EFNA1 EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2, VAV3:RAC1-GTPLYN PI(4,5)P2 EFNA5 p-Y599,Y605-EPHA1 EPHA7 p-Y608,Y614-EPHA7 p-Y383-GIT1 p-Y594,Y600-EPHB1 Smoothmuscle/non-musclemyosin IIEPHA7 Gly p-Y645,Y651-EPHB6 EPHA2 ADPCDC42 NCK2 EFNBs:p-EPHBs:KALRNp-Y645,Y651-EPHB6 p-Y596,Y602-EPHA3 SRC-1 EFNA5 APH1B p-Y596,Y602-EPHB2 GTP p-Y605,Y611-EPHA6 YES1 CLTC GGC-PalmC-RAC1 GDPMYL12B Mg2+ VAV3 p-Y605,Y611-EPHA6 p-S144,T423-PAK1 GTP p-Y596,Y602-EPHA3 EFNB2 PI(4,5)P2p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actinp-Y596,Y602-EPHA4 EPHB2 SDCBPEFNA4 EFNB2 ATPp-Y590,Y596-EPHB4 ITSN1 p-2Y-EPHA10 SRC,FYNp-Y608,Y614-EPHB3 EFNB3 p-Y596,Y602-EPHB2 EFNA2 FYN GTP GDP ATPLYN RHOA:GTP:Mg2+EFNB2 EFNB3 p-Y645,Y651-EPHB6 LYN p-Y596,Y602-EPHB2 EPHB3 LYN EFNB2 p-Y645,Y651-EPHB6 p-Y588,Y594-EPHA2 EFNA4 EPHB4 EPHB4 L-Glu EPHB6 (32-?) GGC-PalmC-RAC1 SRC-1 EFNA4 EFNA1 p-Y610,Y616-EPHA8 AP2B1 EFNB3 EPHB1 p-EPHAs/p-EPHBs:EFNAs/EFNBsEFNB1 EFNB2 SRC-1 SRC-1 EFNB3 p-Y311,Y316,Y330-EFNB2 RAC1:GTP:PAK1dimer:RAC1:GTPEPHA4 p-Y173-VAV3 p-Y608,Y614-EPHB3 GTPARPC5 ADPYES1 GTPCDC42:GDPp-Y599,Y605-EPHA1 GTP EFNA2 EFNB1 HRAS p-Y608,Y614-EPHA7 p190RhoGEF EFNB3 EPHB1 p-Y605,Y611-EPHA6 p-Y608,Y614-EPHB3 PI(4,5)P2 EFNA3 RAC1 p-Y596,Y602-EPHB2 TIAM1 ITSN1 p-Y645,Y651-EPHB6 AP2B1 RAC1:GDPp-Y608,Y614-EPHB3 ATPRHOA EFNAs:p-EPHAs:SFKs:NGEFp-S3-CFL1:p-LIMKADPEPHB1 EPHA10 p-Y610,Y616-EPHA8 p-Y594,Y600-EPHB1 N-WASP p-Y590,Y596-EPHB4 p-Y608,Y614-EPHB3 SRC-1 EFNA3 EPHA8 G-actinN-WASPEPHB1 EPHB1 p-EPHBs:EFNBs:ITSN1RhoA (Mgcofactor):GDPEPHBs:EFNBs:SDCBPACTG1 EPHA4 p-Y324,Y329,Y343-EFNB1 ADPEPHAs:EFNAs:ADAM10p-Y596,Y602-EPHA3 p-Y645,Y651-EPHB6 EFNB1 ARHGEF7 MYH10 SRC-1 VEGFA-165 EFNBsEPHB2 (19-?) EFNB3 SDCBP SRC-1 EFNA1 (19-?) N-ter p-2Y-EPHA10 EFNB2 MYH14 GTPDNM1EPHB3 EFNAs:p-EPHAs:SFKs:TIAM1ATPp-Y645,Y651-EPHB6 YES1 EFNA3 RHOA EPHB4 p-Y383-GIT1 FYN p-Y594,Y600-EPHB1 FYN p-Y324,Y329,Y343-EFNB1 EPHA7 EFNB1 SRC-1 CLTCL1 GIT1EPHB3 EFNB1 GDP LYN ROCK2 p-Y608,Y614-EPHB3 EPHB2 p-Y590,Y596-EPHB4 LYN p-Y645,Y651-EPHB6 p-Y608,Y614-EPHB3 EFNB1 CLTA GDP ACTG1 EPHB4 EPHB3 EPHA6 SRC-1 EFNB1 EPHB4 GTP p-Y590,Y596-EPHB4 p-Y645,Y651-EPHB6 EFNB1 YES1 EPHA1 EFNA3 EPHB3 (?-998) Mg2+ EFNA2 FYN GRIN1 SRC-1 p-Y318,Y323,Y337-EFNB3 FYN ACTR3 p-Y594,Y600-EPHB1 LYN EPHB1 p-Y1252,Y1336,Y1474-GRIN2B EPHB3 GGC-PalmC-RAC1 p-S19-MYL12ASRC-1 EFNBs:p-EPHBs:SFKs:Glu:NMDAR:GlyEFNB3 EFNA5 GDPEPHB1 ATPp-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTPp-Y594,Y600-EPHB1 EFNB1 p-Y645,Y651-EPHB6 p-Y594,Y600-EPHB1 p-Y608,Y614-EPHB3 GRIN2B N-WASP p-Y588,Y594-EPHA2 RASA1p-Y610,Y616-EPHA8 EPHB6 (?-1021) EPHB4 ROCK1 CLTC GRIN1 p-Y397-PTK2 EFNB3 Mg2+ p-Y324,Y329,Y343-EFNB1 RHOA:GTP:Mg2+:Activated ROCK1,ROCK2p-Y645,Y651-EPHB6 EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1Gly FYN EFNA1 EPHB6 FYN p-S141,T402-PAK2 EFNB2 MMP9 FYN EFNA1 p-Y590,Y596-EPHB4 L-Glu p-Y590,Y596-EPHB4 EPHB4 p-Y596,Y602-EPHA4 Mg2+ EFNB2 RHOA:GTP:Mg2+:ROCK1,ROCK2EFNA4 (26-?) N-ter EFNB3 p-Y605,Y611-EPHA6 SRC-1 p-Y594,Y600-EPHB1 EPHB4 GDPNCK2 GDPPAK1 p-Y596,Y602-EPHB2 EFNB1 EFNA5 EPHB6 EPHB2 AP2A1 LYN p-Y645,Y651-EPHB6 EFNA3 EPHB6 GTP EPHA1 EFNB3 GGC-PalmC-RAC1 EFNB3 223, 4223, 4223, 4223, 4223, 4223, 4223, 4223, 42