RAC1/PAK1/p38/MMP2 Pathway (Homo sapiens)

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1NucleusPck(s)CASP7KRASJNKSTMN1ProteasomedegradationERK1PIK3/p85IKK1PIK3RANG2RasGAPPIP3ERBB2FN1TIE1Regulation of Actin CytoskeletonRAD51RELAIKBEGFRIKBKGNCK1MAPK14DOKRERK2SAPKIKK2ABIN-2FKHRSTAT3VaculogenesisNOS1ANG4AKTHRASBADMAPK1ABIN-3TP53SRCPI3K/p110BAXMapkNRASANG1PXNERK1TEKSTAT5ASOS1Cell migration,survival and cell-cell interactionEIF4EBP1GRB14ANG3MYCPAK1RS1MAPK13CASP9ERK2PIP2MAPK8MAPK11MSH2NFKB1YAP1CTNNB1RAC1SHP2SurvivinMAPK14IntegrinABIN-1GRB7MAPK12PPPGRB2PCRKPAK1STAT5BNFKB1IKBPFAKNOS2Angiogenesis


Description

Rac1/p38 pathway from Ingenuity Pathway Analysis.

Quality Tags

Ontology Terms

 

Bibliography

  1. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, Aslan B, Del C Monroig P, Velazquez-Torres G, Previs RA, Pradeep S, Kahraman N, Wang H, Kanlikilicer P, Ozpolat B, Calin G, Sood AK, Lopez-Berestein G; ''Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.''; Clin Cancer Res, 2015 PubMed

History

View all...
CompareRevisionActionTimeUserComment
96971view01:57, 24 April 2018AlexanderPicoadded MMP2 and bolded main axis
96970view01:53, 24 April 2018AlexanderPicoOntology Term : 'ovarian cancer' added !
96969view01:53, 24 April 2018AlexanderPicoModified title
96968view01:52, 24 April 2018AlexanderPicoModified description
94281view18:48, 30 August 2017KhanspersOntology Term : 'signaling pathway' added !
94280view18:48, 30 August 2017KhanspersModified description
94279view18:47, 30 August 2017Khanspersminor layout change
87628view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
83781view15:34, 4 December 2015SusanChanged ID and name of NEMO
81655view21:21, 21 August 2015Khanspers
81652view19:12, 21 August 2015MaintBotModified description
81307view23:49, 17 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABIN-1GeneProductENSG00000145901 (Ensembl)
ABIN-2GeneProductENSG00000168884 (Ensembl)
ABIN-3GeneProductENSG00000050730 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ANG1GeneProductENSG00000154188 (Ensembl)
ANG2GeneProductENSG00000091879 (Ensembl)
ANG3GeneProductENSG00000116194 (Ensembl)
ANG4GeneProductENSG00000101280 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CRKGeneProductENSG00000167193 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Cell migration,

survival and

cell-cell interaction
Pathway
DOKRGeneProductENSG00000147443 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FKHRGeneProductENSG00000150907 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
GRB14GeneProductENSG00000115290 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GRB7GeneProductENSG00000141738 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IKBGeneProductENSG00000100906 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IKK1GeneProductENSG00000213341 (Ensembl)
IKK2GeneProductENSG00000104365 (Ensembl)
IntegrinGeneProductENSG00000150093 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MapkGeneProduct
NCK1GeneProductENSG00000158092 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PI3K/p110GeneProductENSG00000121879 (Ensembl)
PIK3/p85GeneProductENSG00000145675 (Ensembl)
PIK3RGeneProductENSG00000145675 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PIP3MetaboliteHMDB04249 (HMDB)
PXNGeneProductENSG00000089159 (Ensembl)
Pck(s)GeneProduct
Proteasome degradationPathwayWP183 (WikiPathways)
RAC1GeneProductENSG00000136238 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RS1GeneProductENSG00000102104 (Ensembl)
RasGAPGeneProductENSG00000145715 (Ensembl)
Regulation of Actin CytoskeletonPathwayWP51 (WikiPathways)
SAPKGeneProduct5601 (Entrez Gene)
SHP2GeneProductENSG00000179295 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
STMN1GeneProductENSG00000117632 (Ensembl)
SurvivinGeneProductENSG00000089685 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl)
TIE1GeneProductENSG00000066056 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
VaculogenesisPathway
YAP1GeneProductENSG00000137693 (Ensembl)

Annotated Interactions

No annotated interactions

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