Neural Crest Differentiation (Bos taurus)

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9DifferentiationBMP7RHOBMYBITGB1WNT1TFAP2AZIC1PAX3PAX7DLX5MSX1MSX2FOXD3SNAI1SNAI2Snail/SlugWNT3AFZD3GSK3BCTNNB1TCF7L1TCF7L2GBX2AXIN2AXIN1DVL3DVL2DVL1BMP4SMAD1ID1NOTCH1DLL3NOTCH4NOTCH2DLL4NOTCH3DLL1DeltaHEY2TWIST1SOX10FGF2HES5HES1RBPJHES5HES1(high)(intermed)FGFR1FGFR2FGFR3Nuclear TFsZIC5MYCSOX9SOX10ISL1CDH6CDH2E-CADHERINSOX5ETS1EpidermisMesodermNeural plate borderNeuralplatePAX3PAX7NFKB1CDH7TFAP2ASNAI1SNAI2Snail/SlugFOXD3ID1SOX9NFKB2Premigratory CNCCNEUROG1SOX10PHOX2BGFAPOLIG1OLIG2GJB1ASCL1MITFPMP22MPZMBPFOXD3PAX3LHX1LHX2BMP4FGF8FGF19Neurons/gliaMelanocytesChondrocytesAutonomicNervousSystemSensoryNeuronsGliaSOX10PAX3PAX7SOX5MITFHDAC1HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HDAC10HDAC11CTBP2DCTSOX5SOX9COL2A1COL11A2MIAMigratory CNCCWNT8AHOXB134PRTG7OLIG32Other ImplicatedTBX61HOXA110LHX5TLX28TFAP2BDMBX15HAND166


Description

Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143 When citing thies pathway, please reference the source publication (PMID: 19575671).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2064(79263) with a 99.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Callery EM, Thomsen GH, Smith JC; ''A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.''; Dev Biol, 2010 PubMed Europe PMC
  2. Filippi A, Tiso N, Deflorian G, Zecchin E, Bortolussi M, Argenton F; ''The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC
  3. Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW; ''Reiterated Wnt signaling during zebrafish neural crest development.''; Development, 2004 PubMed Europe PMC
  4. Arenkiel BR, Gaufo GO, Capecchi MR; ''Hoxb1 neural crest preferentially form glia of the PNS.''; Dev Dyn, 2003 PubMed Europe PMC
  5. Knight RD, Javidan Y, Zhang T, Nelson S, Schilling TF; ''AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo.''; Development, 2005 PubMed Europe PMC
  6. Ohtoshi A, Bradley A, Behringer RR, Nishijima I; ''Generation and maintenance of Dmbx1 gene-targeted mutant alleles.''; Mamm Genome, 2006 PubMed Europe PMC
  7. Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H; ''Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.''; BMC Dev Biol, 2010 PubMed Europe PMC
  8. Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I; ''''; , PubMed Europe PMC
  9. Betancur P, Bronner-Fraser M, Sauka-Spengler T; ''Assembling neural crest regulatory circuits into a gene regulatory network.''; Annu Rev Cell Dev Biol, 2010 PubMed Europe PMC
  10. Makki N, Capecchi MR; ''Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.''; Dev Biol, 2011 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
101989view06:35, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
80926view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ASCL1GeneProductENSBTAG00000016227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139352
AXIN1GeneProductENSBTAG00000016577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
AXIN2GeneProductENSBTAG00000030162 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8313
BMP4GeneProductENSBTAG00000003835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
BMP7GeneProductENSBTAG00000015362 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101144
CDH2GeneProductENSBTAG00000021190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170558
CDH6GeneProductENSBTAG00000012992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113361
CDH7GeneProductENSBTAG00000014488 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081138
COL11A2GeneProductENSBTAG00000000601 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204248
COL2A1GeneProductENSBTAG00000013155 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139219
CTBP2GeneProductENSBTAG00000003397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175029
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168036
DCTGeneProductENSBTAG00000002300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080166
DLL1GeneProductENSBTAG00000031476 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198719
DLL3GeneProductENSBTAG00000010483 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090932
DLL4GeneProductENSBTAG00000010361 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128917
DLX5GeneProductENSBTAG00000018645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105880
DMBX1GeneProductENSBTAG00000009625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197587
DVL1GeneProductENSBTAG00000010696 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
DVL2GeneProductENSBTAG00000003075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
DVL3GeneProductENSBTAG00000019336 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
DifferentiationPathway
E-CADHERINGeneProductENSBTAG00000015991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000039068
ETS1GeneProductENSBTAG00000002341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134954
FGF19GeneProductENSBTAG00000017285 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162344
FGF2GeneProductENSBTAG00000005691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
FGF8GeneProductENSBTAG00000001530 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831
FGFR1GeneProductENSBTAG00000015457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077782
FGFR2GeneProductENSBTAG00000014064 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066468
FGFR3GeneProductENSBTAG00000007164 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000068078
FOXD3GeneProductENSBTAG00000008501 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187140
FZD3GeneProductENSBTAG00000006621 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104290
GBX2GeneProductENSBTAG00000008898 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168505
GFAPGeneProductENSBTAG00000013534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131095
GJB1GeneProductENSBTAG00000020512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169562
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000082701
HAND1GeneProductENSBTAG00000002335 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113196
HDAC10GeneProductENSBTAG00000011000 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100429
HDAC11GeneProductENSBTAG00000007208 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163517
HDAC1GeneProductENSBTAG00000012698 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116478
HDAC2GeneProductENSBTAG00000011849 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196591
HDAC3GeneProductENSBTAG00000017360 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171720
HDAC4GeneProductENSBTAG00000017764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000068024
HDAC5GeneProductENSBTAG00000016254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108840
HDAC6GeneProductENSBTAG00000013244 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000094631
HDAC7GeneProductENSBTAG00000026819 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000061273
HDAC8GeneProductENSBTAG00000046092 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147099
HDAC9GeneProductENSBTAG00000003808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000048052
HES1GeneProductENSBTAG00000000569 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114315
HES5GeneProductENSBTAG00000002483 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197921
HEY2GeneProductENSBTAG00000000919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135547
HOXA1GeneProductENSBTAG00000013263 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105991
HOXB1GeneProductENSBTAG00000007603 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120094
ID1GeneProductENSBTAG00000016169 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125968
ISL1GeneProductENSBTAG00000001241 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000016082
ITGB1GeneProductENSBTAG00000015910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150093
LHX1GeneProductENSBTAG00000033562 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000273706
LHX2GeneProductENSBTAG00000010990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106689
LHX5GeneProductENSBTAG00000003107 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089116
MBPGeneProductENSBTAG00000022890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
MIAGeneProductENSBTAG00000009078 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8190
MITFGeneProductENSBTAG00000006679 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187098
MPZGeneProductENSBTAG00000033835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158887
MSX1GeneProductENSBTAG00000010875 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163132
MSX2GeneProductENSBTAG00000013873 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120149
MYBGeneProductENSBTAG00000012074 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118513
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
NEUROG1GeneProductENSBTAG00000003331 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181965
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109320
NFKB2GeneProductENSBTAG00000006017 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077150
NOTCH1GeneProductENSBTAG00000022799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
NOTCH2GeneProductENSBTAG00000007909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134250
NOTCH3GeneProductENSBTAG00000043971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000074181
NOTCH4GeneProductENSBTAG00000025424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204301
OLIG1GeneProductENSBTAG00000037547 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184221
OLIG2GeneProduct
OLIG3GeneProductENSBTAG00000008749 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177468
PAX3GeneProductENSBTAG00000009950 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135903
PAX7GeneProductENSBTAG00000014967 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000009709
PHOX2BGeneProductENSBTAG00000044166 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109132
PMP22GeneProductENSBTAG00000019070 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109099
PRTGGeneProductENSBTAG00000005848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166450
RBPJGeneProductENSBTAG00000003602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168214
RHOBGeneProductENSBTAG00000046054 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143878
SMAD1GeneProductENSBTAG00000002835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170365
SNAI1GeneProductENSBTAG00000014554 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124216
SNAI2GeneProductENSBTAG00000013227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019549
SOX10GeneProductENSBTAG00000004822 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100146
SOX5GeneProductENSBTAG00000022360 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134532
SOX9GeneProductENSBTAG00000045824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
TBX6GeneProductENSBTAG00000009046 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149922
TCF7L1GeneProductENSBTAG00000010111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152284
TCF7L2GeneProductENSBTAG00000016462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196628
TFAP2AGeneProductENSBTAG00000001250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137203
TFAP2BGeneProductENSBTAG00000020426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000008196
TLX2GeneProductENSBTAG00000016607 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115297
TWIST1GeneProductENSBTAG00000046922 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122691
WNT1GeneProductENSBTAG00000015364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342
WNT8AGeneProductENSBTAG00000005570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000061492
ZIC1GeneProductENSBTAG00000014751 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152977
ZIC5GeneProductENSBTAG00000046271 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139800

Annotated Interactions

No annotated interactions
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