Farnesoid X Receptor Pathway (Bos taurus)

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21OtherBile acid detoxificationTranscriptionBile acid & xenobiotics transportBile acid conjugationBile acid neosynthesis13131313NR1H434FXR ligandNR1H434RXRALigandGenesTATA boxNR1H434RXRALigandFXRENR1H434LigandRXRAUGT2B4SULT2A1SLC27A5SLC10A1CYP7A1NR0B21248FGF1925IRS2ABCB11BAATCYP3A4FKBP512UQCC2ABCB4NR0B2PPARGC1ASLCO2B148CYP8B1FXR Target genes


Description

The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2879(79602) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  17. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed
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  33. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed
  34. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed
  35. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed
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  38. Bock KW; ''''; , PubMed
  39. ''''; , PubMed
  40. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed
  41. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed
  42. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed
  43. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed
  44. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed
  45. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed
  46. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed
  47. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed
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History

CompareRevisionActionTimeUserComment
88057view13:48, 25 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
80916view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB11GeneProductENSBTAG00000026885 (Ensembl)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8647
ABCB4GeneProductENSBTAG00000005653 (Ensembl)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5244
BAATGeneProductENSBTAG00000025760 (Ensembl)
  • bile acid CoA:amino acid N-acyltransferase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:570
CYP3A4GeneProductENSBTAG00000047379 (Ensembl)
  • cytochrome P450, family 3, subfamily A, polypeptide 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP7A1GeneProductENSBTAG00000005287 (Ensembl)
  • cytochrome P450, family 7, subfamily A, polypeptide 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
CYP8B1GeneProductENSBTAG00000034106 (Ensembl)
  • cytochrome P450, family 8, subfamily B, polypeptide 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1582
FGF19GeneProductENSBTAG00000017285 (Ensembl)
  • fibroblast growth factor 19
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9965
FKBP5GeneProductENSBTAG00000047502 (Ensembl)
  • FK506 binding protein 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2289
FXR ligandMetaboliteCHEBI:48705 (ChEBI) T3
IRS2GeneProductENSBTAG00000012019 (Ensembl)
  • insulin receptor substrate 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
LigandMetaboliteCHEBI:48705 (ChEBI)
NR0B2GeneProductENSBTAG00000014848 (Ensembl)
  • nuclear receptor subfamily 0, group B, member 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8431
NR1H4GeneProductENSBTAG00000013596 (Ensembl)
  • nuclear receptor subfamily 1, group H, member 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971
PPARGC1AGeneProductENSBTAG00000017024 (Ensembl)
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10891
RXRAGeneProductENSBTAG00000017851 (Ensembl)
  • retinoid X receptor, alpha
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
SLC10A1GeneProductENSBTAG00000001881 (Ensembl)
  • solute carrier family 10 (sodium/bile acid cotransporter), member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6554
SLC27A5GeneProductENSBTAG00000015164 (Ensembl)
  • solute carrier family 27 (fatty acid transporter), member 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10998
SLCO2B1GeneProductENSBTAG00000015596 (Ensembl)
  • solute carrier organic anion transporter family, member 2B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11309
SULT2A1GeneProductENSBTAG00000039971 (Ensembl)
  • sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6822
UGT2B4GeneProductENSBTAG00000040337 (Ensembl)
  • UDP glucuronosyltransferase 2 family, polypeptide B4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7363
UQCC2GeneProductENSBTAG00000033603 (Ensembl)
  • inositol hexakisphosphate kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:117283

Annotated Interactions

No annotated interactions
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