Signaling Pathways in Glioblastoma (Bos taurus)

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1654333LegendP13K class 2 signalingProteinRTKFGFR1GRB2IRS1CDKN2APIP3bta-mir-21ERBB3ERRFI1IGF1RPI(3)PPIK3R1PIK3C2BCCND1LPAPDPK1RB1CCNE1bta-mir-21SPRY2FOXO1MAP2K1Cell MigrationAKT1TSC1PTENPIK3C2APIK3C2GPIK3R2PIK3CAPIK3CBPIK3CDAKT2AKT3SRCGAB1PIK3CGFOXO3FOXO4P13K class 1 / AKT signalingPDGFRAPDGFRBERBB2EGFRFGFR2C-METFOXOATKCBLNF1NRASKRASHRASRASARAFBRAFRAF1RAFPLCG1PRKCZPRKCQPRKCHPRKCGPRKCDPRKCIPRKCBPRKCAPLCG2MAP2K2MAP2K3MAP2K4MAP2K5MAP2K6MAP2K7RTK/RAS signalingPLCGPKCMAPK1MAPK3MEKERKCell Cycle ProgressionCDKN1BCDK2CDKN1ATSC2CDKN2CCDKN2BCCND1CCND2CCND2CDK4CDK6E2F1G1/S ProgressionRB signalingCDKN2AMDM2MDM4TP53EP300ATMBRCA1BRCA2BRCA1MSH6INK4ApoptosisG2/M ArrestDNA RepairCell SurvivalP53 signalingProtein FamilyProtein ComplexSmall MoleculeActivatesInhibits


Description

The most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core pathways by TCGA, The Cancer Genome Atlas (see Bibliography). Assembled from literature and public pathway database resources, this representation can easily be kept up-to-date at WikiPathways.org. Sources: cBio Cancer Genomics Portal

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2261(80204) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. ''Comprehensive genomic characterization defines human glioblastoma genes and core pathways.''; Nature, 2008 PubMed
  2. Liu X, Zhang Z, Sun L, Chai N, Tang S, Jin J, Hu H, Nie Y, Wang X, Wu K, Jin H, Fan D; ''MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.''; Carcinogenesis, 2011 PubMed
  3. Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P, Wang B, Wang G, Jia Z, Pu P, Zhang W, Kang C; ''Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.''; Lab Invest, 2010 PubMed
  4. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed
  5. Kwak HJ, Kim YJ, Chun KR, Woo YM, Park SJ, Jeong JA, Jo SH, Kim TH, Min HS, Chae JS, Choi EJ, Kim G, Shin SH, Gwak HS, Kim SK, Hong EK, Lee GK, Choi KH, Kim JH, Yoo H, Park JB, Lee SH; ''Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas.''; Oncogene, 2011 PubMed
  6. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT; ''Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.''; J Biol Chem, 2009 PubMed

History

CompareRevisionActionTimeUserComment
89453view13:02, 15 September 2016Mkutmonremove space in ontology term id
81194view13:57, 3 August 2015Mkutmonfix unconnected lines
80910view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
AKT2GeneProductENSBTAG00000001400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105221
AKT3GeneProductENSBTAG00000017788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117020
ARAFGeneProductENSBTAG00000005039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078061
ATMGeneProductENSBTAG00000003111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149311
ApoptosisPathway
BRAFGeneProductENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157764
BRCA1GeneProductENSBTAG00000022520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000012048
BRCA2GeneProductENSBTAG00000000988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139618
C-METGeneProductENSBTAG00000006161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105976
CBLGeneProductENSBTAG00000006817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110395
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110092
CCND2GeneProductENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118971
CCNE1GeneProductENSBTAG00000004735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105173
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123374
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135446
CDK6GeneProductENSBTAG00000044023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105810
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124762
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111276
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147889
CDKN2BGeneProductENSBTAG00000016412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147883
CDKN2CGeneProductENSBTAG00000011059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123080
Cell Cycle ProgressionPathway
Cell MigrationPathway
Cell SurvivalPathway
DNA RepairPathway
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101412
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146648
EP300GeneProductENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100393
ERBB2GeneProductENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141736
ERBB3GeneProductENSBTAG00000010444 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065361
ERRFI1GeneProductENSBTAG00000006609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116285
FGFR1GeneProductENSBTAG00000015457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077782
FGFR2GeneProductENSBTAG00000014064 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066468
FOXO1GeneProductENSBTAG00000044105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150907
FOXO3GeneProductENSBTAG00000011234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118689
FOXO4GeneProductENSBTAG00000004879 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184481
G1/S ProgressionPathway
G2/M ArrestPathway
GAB1GeneProductENSBTAG00000002813 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109458
GRB2GeneProductENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177885
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174775
IGF1RGeneProductENSBTAG00000021527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140443
IRS1GeneProductENSBTAG00000021308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169047
KRASGeneProduct
LPAMetabolite52288 (ChEBI)
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126934
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000034152
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065559
MAP2K5GeneProductENSBTAG00000000218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137764
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108984
MAP2K7GeneProductENSBTAG00000010639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076984
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102882
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135679
MDM4GeneProductENSBTAG00000006255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198625
MSH6GeneProductENSBTAG00000001424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116062
NF1GeneProductENSBTAG00000011829 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196712
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213281
PDGFRAGeneProductENSBTAG00000007173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134853
PDGFRBGeneProductENSBTAG00000002804 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113721
PDPK1GeneProductENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140992
PI(3)PMetabolite26034 (ChEBI)
PIK3C2AGeneProductENSBTAG00000004901 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000011405
PIK3C2BGeneProductENSBTAG00000024633 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133056
PIK3C2GGeneProductENSBTAG00000020715 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139144
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121879
PIK3CBGeneProductENSBTAG00000006909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000051382
PIK3CDGeneProductENSBTAG00000018984 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171608
PIK3CGGeneProductENSBTAG00000020848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105851
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145675
PIK3R2GeneProductENSBTAG00000002350 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105647
PIP3Metabolite16618 (ChEBI)
PLCG1GeneProductENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181
PLCG2GeneProductENSBTAG00000002103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197943
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
PRKCBGeneProductENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166501
PRKCDGeneProductENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163932
PRKCGGeneProductENSBTAG00000013550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126583
PRKCHGeneProductENSBTAG00000003276 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000027075
PRKCIGeneProductENSBTAG00000001403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163558
PRKCQGeneProductENSBTAG00000010664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065675
PRKCZGeneProductENSBTAG00000014119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067606
PTENGeneProductENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171862
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139687
SPRY2GeneProductENSBTAG00000001774 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136158
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197122
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
TSC1GeneProductENSBTAG00000005190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165699
TSC2GeneProductENSBTAG00000020617 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103197
bta-mir-21RnaENSBTAG00000029897 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004

Annotated Interactions

No annotated interactions
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