Tamoxifen metabolism (Bos taurus)

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1-5MCF-7 cell proliferationDeaminationAlternate pathwayMain pathwayAlcohol metabolismSulfationSulfationSulfationtamoxifen-N-glucuronideSULT2A1SSRIUGT1A4deamino-hydroxytamoxifenSULT1E1Tamoxifen-N-oxideCYP3A4CYP2C19CYP2A6CYP3A4CYP1B1FMO3alpha-hydroxytamoxifen4-hydroxy-N-desmethyltamoxifenUGT1A8CYP3A4CYP3A5trans-4-SulfoxytamoxifenCYP2C9CYP2C9SULT1A1SULT1A1cis-4-hydroxy-N-desmethyltamoxifenCYP2E1CYP2C8CYP3A4SULT2A1SULT1E1FMO1UGT1A10cis-4-hydroxytamoxifenPAPSalpha-hydroxy-N-desmethyltamoxifenCYP1A1PAPtrans-tamoxifen-4-O-glucuronideUGT1A4CYP3A4cis-4-hydroxytamoxifen-N-glucuronidePAPMGC127055MGC127055UGT2B15trans-4-hydroxytamoxifenCYP3A4N-desmethyltamoxifenCYP3A4SULT2A1cis-tamoxifen-4-O-glucuronidetrans-N-desmethyltamoxifen-O-glucuronidePAPSUGT2B7CYP2C19cis-N-desmethyltamoxifen-O-glucuronidetrans-4-Sulfoxytamoxifentrans-4-hydroxytamoxifen-N-glucuronideMGC127055UGT1A4N,N-didesmethyltamoxifenCYP1A2trans-tamoxifenMGC127055MetaboliteCYP3A5CYP2C19


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP691(79986) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jordan VC; ''New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.''; Steroids, 2007 PubMed Europe PMC
  2. Jordan VC; ''Chemoprevention of breast cancer with selective oestrogen-receptor modulators.''; Nat Rev Cancer, 2007 PubMed Europe PMC
  3. Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D; ''Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.''; Ann N Y Acad Sci, 2009 PubMed Europe PMC
  4. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.''; Biochem Pharmacol, 2004 PubMed Europe PMC
  5. Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4.''; Biochem Pharmacol, 2006 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
105940view11:47, 16 August 2019MaintBotHMDB identifier normalization
80908view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-hydroxy-N-desmethyltamoxifenMetabolite3035980 (PubChem-compound)
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP2A6GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
CYP2C19GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165841
CYP2C8GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138115
CYP2C9GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138109
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP3A5GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106258
FMO1GeneProductENSBTAG00000021408 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000010932
FMO3GeneProductENSBTAG00000020597 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007933
MGC127055GeneProductENSBTAG00000026501 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100197
MetaboliteMetaboliteCHEBI:25212 (ChEBI)
N,N-didesmethyltamoxifenMetabolite3036172 (PubChem-compound)
N-desmethyltamoxifenMetabolite3032890 (PubChem-compound)
PAPMetaboliteHMDB00061 (HMDB)
PAPSMetabolite10214 (PubChem-compound)
SSRIMetabolite
SULT1A1GeneProductENSBTAG00000008635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196502
SULT1E1GeneProductENSBTAG00000011952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SULT2A1GeneProductENSBTAG00000039971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105398
Tamoxifen-N-oxideMetabolite
UGT1A10GeneProduct
UGT1A4GeneProductENSBTAG00000048275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54657
UGT1A8GeneProduct
UGT2B15GeneProductENSBTAG00000040337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196620
UGT2B7GeneProductENSBTAG00000040337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7364
alpha-hydroxy-N-desmethyltamoxifenMetabolite
alpha-hydroxytamoxifenMetaboliteHMDB60585 (HMDB)
cis-4-hydroxy-N-desmethyltamoxifenMetabolite
cis-4-hydroxytamoxifenMetabolite
cis-4-hydroxytamoxifen-N-glucuronideMetabolite
cis-N-desmethyltamoxifen-O-glucuronideMetabolite
cis-tamoxifen-4-O-glucuronideMetabolite
deamino-hydroxytamoxifenMetabolite3033897 (PubChem-compound)
tamoxifen-N-glucuronideMetabolite5460873 (PubChem-compound)
trans-4-SulfoxytamoxifenMetabolite
trans-4-hydroxytamoxifen-N-glucuronideMetabolite
trans-4-hydroxytamoxifenMetabolite449459 (PubChem-compound)
trans-N-desmethyltamoxifen-O-glucuronideMetabolite
trans-tamoxifen-4-O-glucuronideMetabolite
trans-tamoxifenMetaboliteHMDB14813 (HMDB)

Annotated Interactions

No annotated interactions
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