Tamoxifen metabolism (Bos taurus)

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1-5DeaminationMain pathwayAlcohol metabolismSulfationAlternate pathwaySulfationSulfationMCF-7 cell proliferationcis-4-hydroxytamoxifentrans-4-SulfoxytamoxifenN,N-didesmethyltamoxifenUGT2B7CYP2C9SULT2A1FMO1CYP3A5CYP3A4CYP2C19CYP3A4UGT2B15CYP1A1Tamoxifen-N-oxideMGC127055UGT1A10SSRICYP3A4PAPCYP2C8CYP2C19trans-4-hydroxytamoxifen-N-glucuronideSULT1E1UGT1A4trans-tamoxifenMGC127055CYP3A4alpha-hydroxy-N-desmethyltamoxifentrans-4-SulfoxytamoxifenSULT2A1FMO3SULT1E1cis-4-hydroxy-N-desmethyltamoxifenSULT1A1alpha-hydroxytamoxifenCYP1A2CYP3A4trans-N-desmethyltamoxifen-O-glucuronideCYP2C19CYP2E1cis-tamoxifen-4-O-glucuronidePAPS4-hydroxy-N-desmethyltamoxifenMetaboliteN-desmethyltamoxifenCYP3A4MGC127055tamoxifen-N-glucuronidePAPStrans-tamoxifen-4-O-glucuronidecis-N-desmethyltamoxifen-O-glucuronidePAPUGT1A8CYP2C9trans-4-hydroxytamoxifenUGT1A4SULT1A1UGT1A4CYP3A4cis-4-hydroxytamoxifen-N-glucuronidedeamino-hydroxytamoxifenCYP2A6CYP1B1SULT2A1CYP3A5MGC127055


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP691(79986) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jordan VC; ''New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.''; Steroids, 2007 PubMed Europe PMC
  2. Jordan VC; ''Chemoprevention of breast cancer with selective oestrogen-receptor modulators.''; Nat Rev Cancer, 2007 PubMed Europe PMC
  3. Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D; ''Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.''; Ann N Y Acad Sci, 2009 PubMed Europe PMC
  4. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.''; Biochem Pharmacol, 2004 PubMed Europe PMC
  5. Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4.''; Biochem Pharmacol, 2006 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
108155view10:41, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
105940view11:47, 16 August 2019MaintBotHMDB identifier normalization
80908view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-hydroxy-N-desmethyltamoxifenMetabolite3035980 (PubChem-compound)
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP2A6GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
CYP2C19GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165841
CYP2C8GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138115
CYP2C9GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138109
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP3A5GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106258
FMO1GeneProductENSBTAG00000021408 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000010932
FMO3GeneProductENSBTAG00000020597 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007933
MGC127055GeneProductENSBTAG00000026501 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100197
MetaboliteMetaboliteCHEBI:25212 (ChEBI)
N,N-didesmethyltamoxifenMetabolite3036172 (PubChem-compound)
N-desmethyltamoxifenMetabolite3032890 (PubChem-compound)
PAPMetaboliteHMDB00061 (HMDB)
PAPSMetabolite10214 (PubChem-compound)
SSRIMetabolite
SULT1A1GeneProductENSBTAG00000008635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196502
SULT1E1GeneProductENSBTAG00000011952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SULT2A1GeneProductENSBTAG00000039971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105398
Tamoxifen-N-oxideMetabolite
UGT1A10GeneProduct
UGT1A4GeneProductENSBTAG00000048275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54657
UGT1A8GeneProduct
UGT2B15GeneProductENSBTAG00000040337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196620
UGT2B7GeneProductENSBTAG00000040337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7364
alpha-hydroxy-N-desmethyltamoxifenMetabolite
alpha-hydroxytamoxifenMetaboliteHMDB60585 (HMDB)
cis-4-hydroxy-N-desmethyltamoxifenMetabolite
cis-4-hydroxytamoxifenMetabolite
cis-4-hydroxytamoxifen-N-glucuronideMetabolite
cis-N-desmethyltamoxifen-O-glucuronideMetabolite
cis-tamoxifen-4-O-glucuronideMetabolite
deamino-hydroxytamoxifenMetabolite3033897 (PubChem-compound)
tamoxifen-N-glucuronideMetabolite5460873 (PubChem-compound)
trans-4-SulfoxytamoxifenMetabolite
trans-4-hydroxytamoxifen-N-glucuronideMetabolite
trans-4-hydroxytamoxifenMetabolite449459 (PubChem-compound)
trans-N-desmethyltamoxifen-O-glucuronideMetabolite
trans-tamoxifen-4-O-glucuronideMetabolite
trans-tamoxifenMetaboliteHMDB14813 (HMDB)

Annotated Interactions

No annotated interactions
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