PPAR Alpha Pathway (Bos taurus)

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14, 28, 34, 44mitochondrial omega-oxidationTranscriptionLipoprotein metabolismperoxisomal beta-oxidationmitochondrial beta-oxidationPhase 2 metabolismCholesterol catabolismHepatocyte proliferationOtherFatty acid transportLigandPPARARXRACo-activatorsGenesTATA boxPPREPPARARXRACo-activatorsLigandACAA1UGT1A9498, 49NR1H3SCP24949CPT1A49APOC3FABP14949CCND149PLTPDBI4949APOA249CPT2APOA14949CYP4A11ACADM49CDK449CYP7A14949MYC49SLC27A149KLK15APOA54949CDK149CYP8B149EHHADH38PPAR alphatarget genes


Description

PPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2878(79689) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  39. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed
  40. ''''; , PubMed
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History

CompareRevisionActionTimeUserComment
88343view16:01, 1 August 2016FehrhartOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
80899view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACAA1GeneProductENSBTAG00000018283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060971
ACADMGeneProductENSBTAG00000024240 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117054
APOA1GeneProductENSBTAG00000002258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118137
APOA2GeneProductENSBTAG00000009212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158874
APOA5GeneProductENSBTAG00000019764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110243
APOC3GeneProductENSBTAG00000012398 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110245
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110092
CDK1GeneProductENSBTAG00000010109 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170312
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135446
CPT1AGeneProductENSBTAG00000021999 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110090
CPT2GeneProductENSBTAG00000014649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157184
CYP4A11GeneProductENSBTAG00000000229 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048
CYP7A1GeneProductENSBTAG00000005287 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167910
CYP8B1GeneProductENSBTAG00000034106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000180432
DBIGeneProductENSBTAG00000009517 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155368
EHHADHGeneProductENSBTAG00000019625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113790
FABP1GeneProductENSBTAG00000018054 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163586
KLK15GeneProductENSBTAG00000018545 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174562
LigandMetaboliteCHEBI:48705 (ChEBI)
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
NR1H3GeneProductENSBTAG00000010681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000025434
PLTPGeneProductENSBTAG00000000559 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100979
PPARAGeneProductENSBTAG00000008063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951
RXRAGeneProductENSBTAG00000017851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186350
SCP2GeneProductENSBTAG00000003746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116171
SLC27A1GeneProductENSBTAG00000016775 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130304
UGT1A9GeneProduct

Annotated Interactions

No annotated interactions
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