Selenium Micronutrient Network (Bos taurus)
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154
72, 86, 129, 148
257
38, 256
129
11, 12, 65, 73, 116...
177
154
92, 113, 143, 154
109, 198
195, 225, 233
203
16, 146
98, 116
3
14
109
60, 93, 143, 228
85
174
Conversion
Protein tyrosine nitration
Tryptophan metabolism
Inhibition
Catalysis
Enzymes
LEGEND
Cofactors
Overarching process
Cofactor conversion
Glycogenesis
Necessary stimulation
Micronutrients
Inflammation and
immune response
Selenoproteins
is composed of
Negative Effect
Prostaglandins metabolism
Other proteins
Leukotriene metabolism
Status
Transcription factor
Stimulation
Ca++ metabolism
Oxidative stress
Biomarker for
Metabolic stress
Reaction
Lipid peroxidation
Lipoprotein melabolism
Cleavage
Process or metabolism involved in Se Pathway
Selenium status
From intracellular part to the plasma
Metabolites
Binding
Intracellular
NAD+ metabolism
ER protein folding
Glutathione metabolism
DNA oxidation
Folate metabolism
Plasma
PGE2
PGG2
a-Tocopherol
PTGS1
EPA
PGH3
PGE2
Arachidonic acid
PGE1
DHA
PGD2
NFKB2
Lipoxin A4
Thromboxane B2
ALA
EPA
8-Isoprostaglandin F2a
PGF2a
MDA
DHA
Lipoxin B4
Thromboxane A2
DPA
8-Isoprostaglandin F2a
DPA
PGI2
Lipoxin B4
Arachidonic acid
Linoleic acid
Thromboxane B2
Lipoxin A4
ALA
F2-Isoprostane
PTGS2
PGH2
PGE1
RELA
PGE3
PGI2
F2-Isoprostane
a-Tocopherol
Linoleic acid
DGLA
PGF2a
PGD2
NFKB1
MDA
119
36, 101, 145
234
13, 110
19, 120, 123, 144, 159...
125, 200
145
98
118
125, 200
182, 237
145, 267
145
99
234
145
49, 99
13
110
58
58
101
145
182, 237
99
101
145, 188
234
12, 44, 58, 99, 118...
73
13
234
58
58
13, 110
99
98
44, 99, 118, 119
145, 186
110
145
125, 200
19, 120, 123, 159, 190
58, 73, 118, 182, 237
Kynurenine
198
MTR
177, 206
TXNRD1
CBS
53, 206
Iodine
Iodine
264
264
KMO
198
15-HETE
Thyroxine (T4)
Triiodothyronine (T3)
5-HETE
R-Triiodothyronine (rT3)
5-HETE
15-HETE
R-Triiodothyronine (rT3)
Thyroxine (T4)
Triiodothyronine (T3)
5,6-Epoxytetraene
5-HPETE
162, 264
162, 264
162, 268
65, 73, 244
234
73, 234
65, 73, 244
162, 264
65, 73, 244
162, 268
162, 268
73
NADP+
CAT
MPO
MPO
154, 227
43, 69, 113, 131
113
Uric acid
38, 147
Cysteine
F2
PLG
SERPINE1
F7
PLAT
PLG
F7
PLAT
GGT1
F2
SERPINE1
54
223, 239
239, 245
54
54
54
239, 245
231
223, 239
54
54
GPX 4
TXNRD2
XDH
147, 169
PRDX5
H2O2
ALOX15B
ALOX5
73, 141
11, 104, 120, 140, 234
Copper
Uric acid
38, 147
Vitamin B12
79, 219
5,10-Methylene-THF
SelR
92, 249
Tryptophan
109, 198
5-methyl-THF
SOD3
PRDX1
RFK
222
H2O
GPX3
Niacinamide
CTH
206
PNPO
31
Heme
3, 36, 53, 154, 227
NADPH
Lipoic acid
72
Manganese
FAD
235
Methionine sulfoxide
92
Dehydroascorbic acid
86, 152
Leukotriene A4
229, 266
NADPH
FAD
235
THF
Hydroxykynurenine
198
Folic acid
177
NADP+
NADPH
Selenium
Selenium
105
105
SELENOK
Sep15
93, 127, 143
68
GPX6
GSH
103
Nicotinamidase
109
Calcium
266
Methionine
92
Manganese
NADPH
Folic acid
177
FMN
235
Selenide
Selenophosphate
Selenocysteine
148, 162
148, 162
148, 162
Cysteine
Leukotriene C4
Leukotriene C4
231, 266
GPX3
209
Dehydroascorbic acid
86
GPX2
SelP
71
Trx-S2
72, 86, 129
Ascorbic acid
152
Lipoic acid
72
PRDX4
GPX 1
NADP+
Homocysteine
ROS
RNS
21, 24, 50, 56, 58...
14, 154
NADPH
Vitamin B12
79, 219
MTHFR
177
Homocysteine
245
DIO1
SelH
SEPHS2
SELENOO
DIO3
SELENOT
SELENOS
DIO2
SELENOV
SELENON
SelP
SELENOI
SELENOM
56, 228, 236
180
17, 50, 71, 78
162, 264
45, 162, 264
82, 85
180
180, 233
162, 262
60, 197, 204
180, 195, 225
180
162, 264
SOD1
Pyridoxal 5'-phosphate
198
Serine
Iron
266
Hypoxanthine
PRDX3
GSR
25
VLDL
VLDL-TAG
APOB
HDL-C
LDL
SAA3
LDLR
TAG
oxLDL
SAA4
HDL
VLDL-TAG
SAA1
SAA2
ABCA1
Cholesterol
HDL-C
VLDL
SERPINA3-7
HDL/SAA
APOA1
oxLDL
HDL/APOA1
SERPINA3-7
FMN
APOA1
HDL
TAG
SCARB1
APOA1
VLDL/APOB
LDL
APOB
Cholesterol
112
43, 116, 144, 146, 224
112
16, 26
114, 187, 201
16, 26
16
112, 208
112
201
43, 116, 146, 224
16, 47
235
16
16
43, 116, 146, 224
16
112
16
16, 26
43, 116, 144, 146, 224
112
114, 187, 201
35
16
112
112, 208
16
112
16, 26, 47
47
16
16
16, 26
O2
98
Pyridoxal 5'-phosphate
198
8-OHdG
FAD
8-OHdG
174
235
174
PRDX2
ADP
Leukotriene D4
Leukotriene D4
231
Chlorine
Copper
Chlorine
Cystathionine
FAD
235
SOD2
Dihydrolipoate
72, 89
Serine
NADP+
ATP
Zinc
NADP+
GSSG
NADPH
Zinc
Niacin
Leukotriene B4
Leukotriene B4
229
229, 266
Quinolinic Acid
109, 198
PMP
NO
HOCl
NO
O3
NO2
HNO2
69, 131
69, 131
NADP+
GSH
85, 103, 229
Fibrinogen
ICAM1
TNF
IL1B
IL1B
ALB
D-dimer
ICAM1
HBA
INS
HbA1c
IFNG
Fibrin
IFNG
Fibrinogen
CCL2
HBG
CCL2
ALOX5AP
IFNG
D-dimer
IFNG
CRP
TNF
Fibrin
INSR
IL6
ALB
HbA1c
IL6
INS
21, 185, 197, 241
197
54, 139
55, 203, 208, 259, 263
197
5, 45, 77
226
55, 203, 259, 263
55, 263
78
45
17, 45, 185
88, 135, 185
90
77, 88, 116, 144
104
54, 139
21, 78
17, 197, 241
226
78
90
5
54, 223
21, 78
88, 135, 185
90
90
45
54, 223
5
SELENOW
83, 103, 155
Riboflavin
240
SOD3
256
TXNRD1
129
Ascorbate
86, 152
O2-“
Xanthine
Calcium
266
KYNU
198
Methionine
92
ADP
Trx-(SH)2
72, 129
ONOO-/ONOOH
Nitrotyrosine
Nitrotyrosine
14
14
ATP
Leukotriene E4
Leukotriene E4
231
Fructosamine
Leukotriene F4
Glucose
Fructosamine
226
90, 203
226
183, 231
Iron
266
Hypoxanthine
TXNRD3
FLAD1
2, 222
Ascorbic acid
19, 152, 190