Selenium Micronutrient Network (Bos taurus)

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15472, 86, 129, 14838, 25611, 12, 65, 73, 116...12925717792, 113, 143, 154154203195, 225, 23398, 11616, 146143109, 1988510960, 93, 143, 228174InhibitionTranscription factorLipid peroxidationReactionCa++ metabolismis composed ofOxidative stressMetabolitesCofactor conversionMetabolic stressBindingInflammation and immune responseLeukotriene metabolismNecessary stimulationProtein tyrosine nitrationFrom intracellular part to the plasmaTryptophan metabolismConversionOverarching processStatusEnzymesNegative EffectCatalysisLipoprotein melabolismBiomarker forCofactorsGlycogenesisCleavageStimulationSelenoproteinsLEGENDProstaglandins metabolismSelenium statusMicronutrientsProcess or metabolism involved in Se PathwayOther proteinsIntracellularGlutathione metabolismNAD+ metabolismER protein foldingFolate metabolismDNA oxidationPlasmaLinoleic acidLinoleic acidPGH2PGE1ALAPGI2DHAPGF2aArachidonic acidPGE2PTGS2a-TocopherolDHAPTGS1ALAPGH3DPALipoxin B4PGG28-Isoprostaglandin F2aPGF2a8-Isoprostaglandin F2aThromboxane B2Lipoxin B4PGE3EPAArachidonic acidF2-IsoprostaneLipoxin A4PGD2Thromboxane B2MDAPGE1NFKB1PGD2Thromboxane A2RELAF2-IsoprostaneDGLAPGE2MDALipoxin A4PGI2DPAa-TocopherolEPANFKB219, 120, 123, 144, 159...99145182, 2375814523412, 44, 58, 99, 118...125, 200145, 188145, 1861185813, 11019, 120, 123, 159, 190101182, 23711013587336, 101, 1452342342341344, 99, 118, 1199814514514549, 9958, 73, 118, 182, 2379998101110145, 267119125, 200125, 20013, 1109958Kynurenine198MTR177, 206TXNRD1CBS53, 206IodineIodine264264KMO1985-HETEThyroxine (T4)15-HETETriiodothyronine (T3)Triiodothyronine (T3)5-HETE5,6-EpoxytetraeneR-Triiodothyronine (rT3)Thyroxine (T4)5-HPETER-Triiodothyronine (rT3)15-HETE65, 73, 24465, 73, 24473162, 26873, 234162, 268162, 268234162, 26465, 73, 244162, 264162, 264NADP+CATMPOMPO43, 69, 113, 131113154, 227Uric acid38, 147CysteinePLATF7PLGF2F2GGT1SERPINE1SERPINE1PLGPLATF75454223, 239239, 2455454231239, 245223, 2395454GPX 4TXNRD2XDH147, 169PRDX5H2O2ALOX15BALOX573, 14111, 104, 120, 140, 234CopperUric acid38, 147Vitamin B1279, 2195,10-Methylene-THFSelR92, 249Tryptophan109, 1985-methyl-THFSOD3PRDX1RFK222H2OGPX3NiacinamideCTH206PNPO31Heme3, 36, 53, 154, 227NADPHLipoic acid72ManganeseFAD235Methionine sulfoxide92Dehydroascorbic acid86, 152Leukotriene A4229, 266NADPHFAD235THFHydroxykynurenine198Folic acid177NADP+NADPHSeleniumSelenium105105SELENOKSep1593, 127, 14368GPX6GSH103Nicotinamidase109Calcium266Methionine92ManganeseNADPHFolic acid177FMN235SelenideSelenophosphateSelenocysteine148, 162148, 162148, 162CysteineLeukotriene C4Leukotriene C4231, 266GPX3209Dehydroascorbic acid86GPX2SelP71Trx-S272, 86, 129Ascorbic acid152Lipoic acid72PRDX4GPX 1NADP+HomocysteineRNSROS21, 24, 50, 56, 58...14, 154NADPHVitamin B1279, 219MTHFR177Homocysteine245SELENOSSELENOMDIO1SELENONSELENOOSelPSelHSELENOTSEPHS2DIO2SELENOVSELENOIDIO360, 197, 204162, 264162, 26217, 50, 71, 78180180, 23345, 162, 264162, 264180, 195, 22582, 8556, 228, 236180180SOD1Pyridoxal 5'-phosphate198SerineIron266HypoxanthinePRDX3GSR25SCARB1SERPINA3-7ABCA1oxLDLVLDLVLDL/APOBVLDLVLDL-TAGAPOBHDLAPOA1oxLDLHDL/APOA1TAGHDL-CAPOA1LDLVLDL-TAGHDLTAGCholesterolSAA1SERPINA3-7FMNAPOA1APOBHDL/SAASAA2SAA3LDLHDL-CLDLRCholesterolSAA42011643, 116, 146, 224112, 2081643, 116, 144, 146, 224161121643, 116, 144, 146, 2241643, 116, 146, 22416, 2616, 26112112163516, 261616, 26471623511211216, 26, 47114, 187, 201112114, 187, 2011616, 47112112, 208O298Pyridoxal 5'-phosphate1988-OHdGFAD8-OHdG174174235PRDX2ADPLeukotriene D4Leukotriene D4231ChlorineCopperChlorineCystathionineFAD235SOD2Dihydrolipoate72, 89SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B4229, 266229Quinolinic Acid109, 198PMPHNO2NOO3HOClNONO269, 13169, 131NADP+GSH85, 103, 229D-dimerCCL2IL1BCRPFibrinogenTNFIFNGHbA1cIL6HbA1cICAM1IL1BINSRCCL2INSTNFINSHBAIFNGIFNGIFNGFibrinogenALBD-dimerFibrinHBGICAM1FibrinALBALOX5APIL654, 1392265, 45, 7719721, 7821, 7854, 13988, 135, 18521, 185, 197, 24190909017, 197, 24155, 203, 208, 259, 2634551044555, 203, 259, 26355, 26319717, 45, 18577, 88, 116, 14454, 22322657854, 2239088, 135, 18578SELENOW83, 103, 155Riboflavin240SOD3256TXNRD1129Ascorbate86, 152O2-“XanthineCalcium266KYNU198Methionine92ADPTrx-(SH)272, 129NitrotyrosineONOO-/ONOOHNitrotyrosine1414ATPLeukotriene E4Leukotriene E4231FructosamineLeukotriene F4FructosamineGlucose226226183, 23190, 203Iron266HypoxanthineTXNRD3FLAD12, 222Ascorbic acid19, 152, 190