Cardiac Hypertrophic Response (Bos taurus)

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Nucleus1G-beta-gammaStressG alpha-q/alpha-11TranscriptionfactorsCellularProteinsNIKGPCRCalmodulinCa2+GUCA1AMAP3K1MAP3K7PLA2G2APPP3CAPLCFGFR2RTKsTGFBR1GPCRTNFRSF1AIns(1,4,5)P3CAMK2DMEF2ADAGPRKCAPRKD1Endo-1Ang-IICatecholaminesNPPABNPcGMPPRKG1Ca2+NFATC2NFATC2MAP4K1MAPK8RASRAC1ROHRAF1MAP2K2MAP2K1MAPK3MAPK1MAP2K4MAP2K7StretchMAP3K1MAP3K1MAPK7MAP2K5StressMAP2K6MAP2K3MAPK14IKBKBIKBKENFKB1NFKB1Pol IICDK7CDK9PI3KPDPK1AKT1AKT2GSK3BProtein SynthesisMTORTNFTGFB1GGFBPP5EGFIGF-IFGF2HDAC4HDAC7HDAC5HDAC9HDAC4HDAC7HDAC5HDAC9CHUKIKBKG


Description

Integrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2795(78544) with a 83.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed

History

CompareRevisionActionTimeUserComment
80883view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AKT2GeneProductENSBTAG00000001400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
Ang-IIMetaboliteHMDB01035 (HMDB)
BNPProtein
CAMK2DGeneProductENSBTAG00000014463 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:817
CDK7GeneProductENSBTAG00000011046 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1022
CDK9GeneProductENSBTAG00000004695 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1025
CHUKGeneProductENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
Ca2+MetaboliteHMDB00464 (HMDB)
CalmodulinGeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000001575;En:ENSBTAG00000025644;
CatecholaminesMetabolite
DAGMetaboliteHMDB07009 (HMDB)
EGFProtein
Endo-1Protein
FGF2ProteinENSBTAG00000005691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2247
FGFR2ProteinENSBTAG00000014064 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2263
GGFBPP5ProteinENSBTAG00000004150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3084
GPCRProtein
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
GUCA1AGeneProductENSBTAG00000012823 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2978
HDAC4GeneProductENSBTAG00000017764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9759
HDAC5GeneProductENSBTAG00000016254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10014
HDAC7GeneProductENSBTAG00000026819 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51564
HDAC9GeneProductENSBTAG00000003808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9734
IGF-IProteinENSBTAG00000011082 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKEGeneProductENSBTAG00000010408 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9641
IKBKGGeneProductENSBTAG00000006268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
Ins(1,4,5)P3MetaboliteHMDB01498 (HMDB)
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K5GeneProductENSBTAG00000000218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAP2K7GeneProductENSBTAG00000010639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5609
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAP4K1GeneProductENSBTAG00000021145 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK7GeneProductENSBTAG00000001014 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MEF2AGeneProductENSBTAG00000010649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4205
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
NFATC2GeneProductENSBTAG00000018270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4773
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NIKGeneProduct
NPPAProteinENSBTAG00000006709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4878
PDPK1GeneProductENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PLA2G2AGeneProductENSBTAG00000005759 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5320
PLCGeneProduct
PPP3CAGeneProductENSBTAG00000016005 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKD1GeneProductENSBTAG00000012789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
PRKG1GeneProductENSBTAG00000018404 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5592
Pol IIGeneProduct
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RASGeneProduct
ROHGeneProduct
RTKsProtein
TGFB1ProteinENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TGFBR1ProteinENSBTAG00000018035 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TNFProteinENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
TNFRSF1AProteinENSBTAG00000004211 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7132
cGMPMetaboliteHMDB01314 (HMDB)

Annotated Interactions

No annotated interactions
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