Tryptophan metabolism (Bos taurus)

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Indole-3-acetateIsophenoxazine2,3-DihydroxyindoleL-Tryptophanyl-tRNA6-Hydroxykynurenate3-Hydroxyanthranilate5-(2'-Formylethyl)-4,6-dihydroxypicolinate3-Methyldioxyindole7,8-Dihydroxykynurenate2-Oxoglutarate2-Oxoadipate3-Hydroxy-L-kynurenine5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolin3-IndoleglycolaldehydeIndole-3-acetaldoxime2-Amino-3-carboxymuconate4-(2-Aminophenyl)-2,4-dioxobutanoateQuinolinate2-Formylaminobenzaldehyde(Z)-5-Oxohex-2-enedioate3-Methylindolepyruvate5-HydroxykynurenamineIndolepyruvateOxaloacetate2-Aminomuconate3-(2-Aminoethyl)-1H-indol-5-olIndole-3-ethanolN-Acetylindoxyl3-Hydroxykynurenamine5-Hydroxyindoleacetylglycine2-Aminomuconate4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate3-Methoxyanthranilate7,8-Dihydro-7,8-dihydroxykynurenateFormyl-5-hydroxykynurenamine5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate5-Methoxyindoleacetate6-HydroxyindolelactateAnthranilate5-HydroxyindoleacetateC011442-FormaminobenzoylacetateBenzoate degradation via hydroxylation8-MethoxykynurenateFormylanthranilateKynurenateIndole-3-acetaldehydeIndolelactate4,8-DihydroxyquinolineGlucobrassicinAnthranilate5-HydroxyindolepyruvateCinnavalininateFormyl-N-acetyl-5-methoxykynurenamineCYP4F125-HydroxykynurenineCYP7B15-MethoxytryptamineHAAO1.10.3.4Cyp2b15IDO11.1.1.1912.1.1.49INMTALDH3A23.5.99.5AADATBenzoate degradation via hydroxylationUBE3AN-Methylserotonin3.5.1.4Phenylalanine, Tyrosine and Tryptophan metabolism1.2.3.71.13.11.231.14.99.2Indole-3-acetamideALDH1A1AOX1Cyp2d2ALDH3A23.5.5.1ACAT1CYP1A26-HydroxymelatoninHRMT1L2MDM21.2.1.32KYNU1.14.16.-KYNU4.1.1.43AFMIDCrotonoyl-CoA1.3.1.181.5.1.-RNF253-IndoleacetonitrileCyp2a24,6-DihydroxyquinolineALDH2RNF25TryptamineAcetyl-CoA3.2.1.1472.6.1.27ACMSDDDCIndoleALDH2DDCFormylkynurenineHSD17B10L-KynurenineAcetoacetyl-CoAMDM2CYP2J21.2.1.-N-MethyltryptamineCyp2c121.14.13.9Glutaryl-CoAMDM2CYP1B1CYP2F14.1.99.1CYP2E1GCDHDHCR24ECHS1Cyp2a14-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate5-Hydroxy-L-tryptophanWARSGlycolysis/Gluconeogenesis2-AminophenolUBR5CYP1A1TDO2DDCHADH1.13.11.17IDO1CYP2A13UBE3AALDH1A1ALDH9A1Aldh1a4CYP2C181.13.12.3ALDH1A2N-AcetylisatinABP1GCDH1.7.3.2CATXanthurenic acid3.5.1.9ALDH9A1MAOB3.5.1.49OGDH1.13.99.3AANAT2.1.1.475-Hydroxy-N-formylkynurenineTPH1IDO12.6.1.27HRMT1L2MAOBASMT5-HydroxyindoleacetaldehydeHRMT1L2Nicotinate and nicotinamide metabolism1.4.3.22.6.1.27L-TryptophanASMT1.13.11.105-(2'-Carboxyethyl)-4,6-DihydroxypicolinateCYP19A11.13.11.-CYP3A4KYNUMAOBAldh1a4AADAT1.1.1.1901.14.16.3Cyp2c39Melatonin4.2.1.84ALDH1A24.1.1.-MAOBN-Acetylserotonin1.1.1.110


Description

This pathway describes the metabolism of tryptophan, an essential amino acid. Originally converted from rat to human using ortholog information. Edited by Sebastien Burel

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP465(79226) with a 61.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
105983view11:51, 16 August 2019MaintBotHMDB identifier normalization
104911view19:20, 24 June 2019KhanspersModified description
104910view19:19, 24 June 2019Khanspersremoved genmapp comments
104820view12:56, 19 June 2019FehrhartModified description
97841view07:56, 10 June 2018EgonwUndo revision 97773 by [[Special:Contributions/Mick Eikelhof|Mick Eikelhof]] ([[User talk:Mick Eikelhof|Talk]])
97773view13:35, 7 June 2018Mick EikelhofModified description
85056view10:50, 10 April 2016Egonw
80880view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Z)-5-Oxohex-2-enedioateMetabolite(Z)-5-Oxohex-2-enedioate
1.1.1.110GeneProduct
1.1.1.190GeneProduct
1.1.1.191GeneProduct
1.10.3.4GeneProduct
1.13.11.-GeneProduct
1.13.11.10GeneProduct
1.13.11.17GeneProduct
1.13.11.23GeneProduct
1.13.12.3GeneProduct
1.13.99.3GeneProduct
1.14.13.9GeneProduct
1.14.16.-GeneProduct
1.14.16.3GeneProduct
1.14.99.2GeneProduct
1.2.1.-GeneProduct
1.2.1.32GeneProduct
1.2.3.7GeneProduct
1.3.1.18GeneProduct
1.4.3.2GeneProduct
1.5.1.-GeneProduct
1.7.3.2GeneProduct
2,3-DihydroxyindoleMetabolite20546 (Chemspider)
2-Amino-3-carboxymuconateMetabolite2-Amino-3-carboxymuconate
2-AminomuconateMetabolite2-Aminomuconate
2-AminophenolMetabolite95-55-6 (CAS) 2-Aminophenol
2-Formamino benzoylacetateMetabolite2-Formaminobenzoylacetate
2-FormylaminobenzaldehydeMetabolite389 (Chemspider)
2-OxoadipateMetabolite19951093 (Chemspider) 2-Oxoadipate
2-OxoglutarateMetabolite144236 (Chemspider) 2-Oxoglutarate
2.1.1.47GeneProduct
2.1.1.49GeneProduct
2.6.1.27GeneProduct
3-(2-Aminoethyl) -1H-indol-5-olMetabolite5013 (Chemspider) 3-(2-Aminoethyl)-1H-indol-5-ol
3-Hydroxy- L-kynurenineMetabolite3-Hydroxy-L-kynurenine
3-HydroxyanthranilateMetabolite7822291 (Chemspider) 3-Hydroxyanthranilate
3-HydroxykynurenamineMetabolite3-Hydroxykynurenamine
3-IndoleacetonitrileMetabolite771-51-7 (CAS) 3-Indoleacetonitrile
3-IndoleglycolaldehydeMetabolite388979 (Chemspider)
3-MethoxyanthranilateMetabolite7827589 (Chemspider) 3-Methoxyanthranilate
3-MethyldioxyindoleMetabolite
3-MethylindolepyruvateMetabolite3-Methylindolepyruvate
3.2.1.147GeneProduct
3.5.1.4GeneProduct
3.5.1.49GeneProduct
3.5.1.9GeneProduct
3.5.5.1GeneProduct
3.5.99.5GeneProduct
4,6-DihydroxyquinolineMetaboliteHMDB04077 (HMDB)
4,8-DihydroxyquinolineMetabolite389608 (Chemspider) 4,8-Dihydroxyquinoline
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateMetaboliteHMDB04083 (HMDB)
4-(2-Amino-5-hydroxyphenyl) -2,4-dioxobutanoateMetabolite389617 (Chemspider) 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoateMetabolite19951260 (Chemspider) 4-(2-Aminophenyl)-2,4-dioxobutanoate
4.1.1.-GeneProduct
4.1.1.43GeneProduct
4.1.99.1GeneProduct
4.2.1.84GeneProduct
5-(2'-Carboxyethyl)-4,6-DihydroxypicolinateMetaboliteHMDB06794 (HMDB)
5-(2'-Formylethyl)-4,6-dihydroxypicolinateMetabolite30791294 (Chemspider) 5-(2'-Formylethyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinMetabolite5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateMetabolite30791292 (Chemspider) 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
5-Hydroxy-L-tryptophanMetaboliteHMDB00472 (HMDB)
5-Hydroxy-N-formylkynurenineMetaboliteHMDB04086 (HMDB)
5-HydroxyindoleacetaldehydeMetaboliteHMDB04073 (HMDB)
5-HydroxyindoleacetateMetabolite10637170 (Chemspider) 5-Hydroxyindoleacetate
5-HydroxyindoleacetylglycineMetabolite
5-HydroxyindolepyruvateMetabolite
5-HydroxykynurenamineMetabolite5-Hydroxykynurenamine
5-HydroxykynurenineMetabolite484-78-6 (CAS)
5-MethoxyindoleacetateMetabolite14533147 (Chemspider) 5-Methoxyindoleacetate
5-MethoxytryptamineMetabolite608-07-1 (CAS)
6-HydroxyindolelactateMetabolite6-Hydroxyindolelactate
6-HydroxykynurenateMetabolite6-Hydroxykynurenate
6-HydroxymelatoninMetabolite2208-41-5 (CAS)
7,8-Dihydro-7,8-dihydroxykynurenateMetabolite7,8-Dihydro-7,8-dihydroxykynurenate
7,8-DihydroxykynurenateMetabolite7,8-Dihydroxykynurenate
8-MethoxykynurenateMetabolite8-Methoxykynurenate
AADATGeneProductENSBTAG00000010326 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51166
AANATGeneProductENSBTAG00000014682 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:15
ABP1GeneProductENSBTAG00000005419 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26
ACAT1GeneProductENSBTAG00000012885 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:38
ACMSDGeneProductENSBTAG00000008039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:130013
AFMIDGeneProductENSBTAG00000007125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:125061
ALDH1A1GeneProductENSBTAG00000008103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:216
ALDH1A2GeneProductENSBTAG00000010119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8854
ALDH2GeneProductENSBTAG00000008743 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:217
ALDH3A2GeneProductENSBTAG00000039161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:224
ALDH9A1GeneProductENSBTAG00000017852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:223
AOX1GeneProductENSBTAG00000009725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:316
ASMTGeneProductENSBTAG00000047124 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:438
Acetoacetyl-CoAMetaboliteC00332 (KEGG Compound)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
Aldh1a4GeneProduct
AnthranilateMetabolite4573598 (Chemspider) Anthranilate
Benzoate degradation via hydroxylationPathway
C01144Metabolite(S)-3-Hydroxybutanoyl-CoA
CATGeneProductENSBTAG00000020980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:847
CYP19A1GeneProductENSBTAG00000014890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1588
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1543
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1544
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1545
CYP2A13GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1553
CYP2C18GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1562
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1571
CYP2F1GeneProductENSBTAG00000046805 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1572
CYP2J2GeneProductENSBTAG00000013693 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1573
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP4F12GeneProductENSBTAG00000038549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:66002
CYP7B1GeneProductENSBTAG00000001299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9420
CinnavalininateMetaboliteCinnavalininate
Crotonoyl-CoAMetaboliteC00877 (KEGG Compound)
Cyp2a1GeneProduct
Cyp2a2GeneProduct
Cyp2b15GeneProduct
Cyp2c12GeneProduct
Cyp2c39GeneProduct
Cyp2d2GeneProduct
DDCGeneProductENSBTAG00000020869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1644
DHCR24GeneProductENSBTAG00000004688 (Ensembl)
  • predicted
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1718
ECHS1GeneProductENSBTAG00000017710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1892
Formyl-5-hydroxykynurenamineMetabolite
Formyl-N-acetyl-5- methoxykynurenamineMetaboliteFormyl-N-acetyl-5-methoxykynurenamine
FormylanthranilateMetaboliteFormylanthranilate
FormylkynurenineMetabolite1022-31-7 (CAS) Formylkynurenine
GCDHGeneProductENSBTAG00000016211 (Ensembl)
  • predicted
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2639
GlucobrassicinMetaboliteGlucobrassicin
Glutaryl-CoAMetaboliteC00527 (KEGG Compound)
Glycolysis/GluconeogenesisPathwayWP534 (WikiPathways)
HAAOGeneProductENSBTAG00000004674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23498
HADHGeneProductENSBTAG00000002049 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3033
HRMT1L2GeneProductENSBTAG00000001357 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276
HSD17B10GeneProductENSBTAG00000017779 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3028
IDO1GeneProductENSBTAG00000020602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3620
INMTGeneProductENSBTAG00000001448 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11185
Indole-3-acetaldehydeMetabolite778 (Chemspider) Indole-3-acetaldehyde
Indole-3-acetaldoximeMetabolite388896 (Chemspider) Indole-3-acetaldoxime
Indole-3-acetamideMetabolite879-37-8 (CAS) Indole-3-acetamide
Indole-3-acetateMetabolite779 (Chemspider) Indole-3-acetate
Indole-3-ethanolMetabolite10235 (Chemspider)
IndoleMetabolite120-72-9 (CAS)
IndolelactateMetabolite28571995 (Chemspider) Indolelactate
IndolepyruvateMetabolite24775813 (Chemspider) Indolepyruvate
IsophenoxazineMetaboliteIsophenoxazine
KYNUGeneProductENSBTAG00000032277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8942
KynurenateMetabolite4-Hydroxy-2-quinolinecarboxylic
L-KynurenineMetabolite343-65-7 (CAS) L-Kynurenine
L-TryptophanMetabolite73-22-3 (CAS)
L-Tryptophanyl-tRNAMetabolite
MAOBGeneProductENSBTAG00000001288 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4129
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MelatoninMetaboliteHMDB01389 (HMDB)
N-AcetylindoxylMetaboliteN-Acetylindoxyl
N-AcetylisatinMetabolite574-17-4 (CAS) N-Acetylisatin
N-AcetylserotoninMetabolite1210-83-9 (CAS) N-Acetylserotonin
N-MethylserotoninMetaboliteHMDB04369 (HMDB)
N-MethyltryptamineMetaboliteCHEBI:28136 (ChEBI)
Nicotinate and nicotinamide metabolismPathway
OGDHGeneProductENSBTAG00000006029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4967
OxaloacetateMetabolite2509917 (Chemspider) Oxaloacetate
Phenylalanine, Tyrosine and Tryptophan metabolismPathway
QuinolinateMetabolite2777129 (Chemspider)
RNF25GeneProductENSBTAG00000003817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64320
TDO2GeneProductENSBTAG00000011062 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6999
TPH1GeneProductENSBTAG00000005343 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7166
TryptamineMetabolite61-54-1 (CAS)
UBE3AGeneProductENSBTAG00000002487 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7337
UBR5GeneProductENSBTAG00000021209 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51366
WARSGeneProductENSBTAG00000004679 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7453
Xanthurenic acidMetaboliteHMDB00881 (HMDB)

Annotated Interactions

No annotated interactions
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