Aflatoxin B1 metabolism (Bos taurus)

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2-5, 7-101, 61, 6nonenzymatic(pH-dependent)nonenzymaticDNA adductsAflatoxin B1 C8-monoalcoholAflatoxin B1 C6-monoalcoholAflatoxin B1 dialdehydeCYP1A2Aflatoxin B1 C6-monoaldehydeCYP2A13Aflatoxin-endo-B1-8,9-epoxideAflatoxin B1 C8-monoaldehydeCYP3A4AKR7A2GSTT1Aflatoxin B1 exo-8,9-epoxide-GSHAKR7A2CYP3A4aflatoxin B1Aflatoxin B1-6,8-dialcoholAflatoxin M1 epoxideCYP2A13CYP1A2GSTM1Aflatoxin B1 8,9-dihydrodiolCYP1A2Aflatoxin M1Aflatoxin B1 exo-8,9-epoxideAflatoxin Q1EPHX1


Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP699(70509) with a 83.0% conversion rate.

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  1. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC
  2. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC
  3. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC
  4. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC
  5. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC
  6. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC
  7. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC
  8. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC
  9. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC
  10. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC


105915view11:40, 16 August 2019MkutmonHMDB identifier normalization
80876view15:29, 30 June 2015MkutmonNew pathway

External references


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NameTypeDatabase referenceComment
AKR7A2GeneProductENSBTAG00000012289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162482
AKR7A2GeneProductENSBTAG00000026758 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000053371
Aflatoxin B1 8,9-dihydrodiolMetabolite
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem-compound)
Aflatoxin B1 exo-8,9-epoxideMetaboliteHMDB06558 (HMDB)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem-compound)
Aflatoxin Q1Metabolite104757 (PubChem-compound)
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP2A13GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197838
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
EPHX1GeneProductENSBTAG00000000140 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143819
aflatoxin B1MetaboliteHMDB06552 (HMDB)

Annotated Interactions

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