Endoderm Differentiation (Bos taurus)

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NucleusSTAT1NANOGCDYLSFMBT1UBR5SOX21C1QBPBTAF1ZIC3PTHLHEPB41L5LAMC1PRDM14SMAD3NME1RTF1RFX7TGFB1NODALRARGBPTFTRIM71SOX17FOXN3GATA4MBTD1HNF1BNAA15PAX9LRPPRCLEO1MBTD1OTX2CTBP2CEBPZDAB2WWC1DNMT3BSFRP1GDF3WDHD1PBX1KDM4ANOTCH1SP4HOXA1EXT1PAF1JARID2PABPC1EOMESPOU5F1ONECUT1TCF7L1FOXA1NKX2-1CTNNB1TCF7MIXL1CTBP2ZNF462CTR9TAF4BDUSP5SMAD4ZFHX4TAF5WNT8AELAVL1MAD2L2CER1FOXA2FOXO1MTF2DKK1ZIC5PAX3APPAEBP2FOXN3TNRC6CBMPR-IATBX21SMAD2NCAPG2CAND1AEBP2BMP7WWC1SOX2ASCC3AEBP2NOGZBTB17DUSP4CDC73ZNF281LEF1HOXC11GRHL2TCEAL2HHEXSP4GATA6RARGJARID2TET1GLI2LHX1MIR653ELK4DIP2APIAS1CRTC1AHDC1PBX3NLKBCORL1ZFHX4PLCH1WDFY2RARGPARP8WDFY2GRHL2SESN1RGS10CUL4BDDAH1SESN1ASCC3ZNF462NABP2PBX1ELP4SCHIP1PLCH1PARP8TRIM5CEP250PHF6ZNF462HPRT1MBTD1PBX1TCF4TOX3SLC2A12ACACAC11orf30C11orf30TOXTRERF1ATP8B2HPRT1TRERF1VAV3TCF4MIR653 Targets(Induced in Ectoderm)MIR653 Targets(Induced in Stem Cells)MIR373 Targets(Induced in Stem Cells)MIR373 Targets(Induced in Ectoderm)MIR375 Targets(Induced in Ectoderm)MIR375 Targets(Induced in Stem Cells)MIR373bta-mir-375MIR141 Targets(Induced in Stem Cells)bta-mir-141MIR132 Targets(Induced in Stem Cells)MIR132MIR132 Targets(Induced in Ectoderm)GR-ADUSP26EZH2FOXH18SIAH2RAB381APC7SOX7MAP2K3932WNT3


Description

Model depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2853(80410) with a 39.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Kang, Won, Rhee, Ro; ''Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development.''; Molecules and Cells, 2014 PubMed Europe PMC
  2. Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP; ''Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.''; Development, 2008 PubMed Europe PMC
  3. Sui, Mfopou, Geens, Sermon, Bouwens; ''FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.''; Biochem Biophys Res Commun., 2012 PubMed Europe PMC
  4. Bourillot, Aksoy, Schreiber, Wianny, Schulz, Hummel, Hubner, Savatier; ''Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.''; Stem Cells, 2009 PubMed Europe PMC
  5. Tsuneyoshi, Tan, Poobalan, Sumi, Nakatsuji, Suemori, Dunn; ''The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.''; Genes Dev., 2012 PubMed Europe PMC
  6. Chappell, Sun, Singh, Dalton; ''MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7''; Genes Dev, 2013 PubMed Europe PMC
  7. Putzke, Rothman; ''Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.''; Proc Natl Acad Sci USA, 2010 PubMed Europe PMC
  8. Kim, Yoon, Chuong, Oyolu, Wills, Gupta, Baker; ''Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs''; Developmental Biology, 2011 PubMed Europe PMC
  9. Futaki, Hayashi, Emoto, Weber, Sekiguchi; ''Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression.''; Mol Cell Biol., 2004 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
87982view13:20, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80866view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACACAGeneProduct
AEBP2GeneProduct
AHDC1GeneProduct
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134982
APPGeneProductENSBTAG00000017753 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142192
ASCC3GeneProduct
ATP8B2GeneProduct
BCORL1GeneProduct
BMP7GeneProductENSBTAG00000015362 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101144
BMPR-IAGeneProductENSBTAG00000000231 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107779
BPTFGeneProductENSBTAG00000014598 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171634
BTAF1GeneProduct
C11orf30GeneProduct
C1QBPGeneProduct
CAND1GeneProductENSBTAG00000009939 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111530
CDC73GeneProductENSBTAG00000016703 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134371
CDYLGeneProduct
CEBPZGeneProduct
CEP250GeneProduct
CER1GeneProductENSBTAG00000020140 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147869
CRTC1GeneProduct
CTBP2GeneProduct
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168036
CTR9GeneProductENSBTAG00000015566 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198730
CUL4BGeneProduct
DAB2GeneProductENSBTAG00000016152 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000153071
DDAH1GeneProduct
DIP2AGeneProduct
DKK1GeneProductENSBTAG00000014218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984
DNMT3BGeneProduct
DUSP2GeneProductENSBTAG00000020350 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158050
DUSP4GeneProductENSBTAG00000044208 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120875
DUSP5GeneProductENSBTAG00000020283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138166
ELAVL1GeneProductENSBTAG00000000613 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066044
ELK4GeneProduct
ELP4GeneProduct
EOMESGeneProductENSBTAG00000016920 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163508
EPB41L5GeneProductENSBTAG00000018236 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115109
EXT1GeneProductENSBTAG00000006209 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182197
EZH2GeneProductENSBTAG00000009426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106462
FOXA1GeneProductENSBTAG00000013888 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129514
FOXA2GeneProductENSBTAG00000012407 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125798
FOXH1GeneProductENSBTAG00000004761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160973
FOXN3GeneProduct
FOXO1GeneProduct
GATA4GeneProductENSBTAG00000005425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136574
GATA6GeneProductENSBTAG00000005734 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141448
GDF3GeneProductENSBTAG00000023192 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184344
GLI2GeneProduct
GR-AGeneProductENSBTAG00000019472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113580
GRHL2GeneProduct
HHEXGeneProductENSBTAG00000014217 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152804
HNF1BGeneProduct
HOXA1GeneProductENSBTAG00000013263 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105991
HOXC11GeneProductENSBTAG00000006879 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123388
HPRT1GeneProduct
JARID2GeneProduct
JARID2GeneProductENSBTAG00000012938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000008083
KDM4AGeneProduct
LAMC1GeneProductENSBTAG00000011966 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135862
LEF1GeneProductENSBTAG00000006844 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138795
LEO1GeneProductENSBTAG00000013830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166477
LHX1GeneProduct
LRPPRCGeneProduct
MAD2L2GeneProduct
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000034152
MBTD1GeneProduct
MIR132GeneProduct
MIR373GeneProduct
MIR653GeneProduct
MIXL1GeneProductENSBTAG00000002139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185155
MTF2GeneProduct
NAA15GeneProduct
NABP2GeneProduct
NANOGGeneProductENSBTAG00000020916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111704
NCAPG2GeneProduct
NKX2-1GeneProductENSBTAG00000000541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136352
NLKGeneProduct
NME1GeneProduct
NODALGeneProductENSBTAG00000013090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574
NOGGeneProductENSBTAG00000040282 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691
NOTCH1GeneProductENSBTAG00000022799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
ONECUT1GeneProductENSBTAG00000046470 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169856
OTX2GeneProductENSBTAG00000014741 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165588
PABPC1GeneProductENSBTAG00000046358 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070756
PAF1GeneProductENSBTAG00000020428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006712
PARP8GeneProduct
PAX3GeneProduct
PAX9GeneProductENSBTAG00000009186 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198807
PBX1GeneProduct
PBX3GeneProduct
PHF6GeneProduct
PIAS1GeneProduct
PLCH1GeneProduct
POU5F1GeneProductENSBTAG00000001873 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204531
PRDM14GeneProductENSBTAG00000000060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147596
PTHLHGeneProductENSBTAG00000006538 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087494
RAB38GeneProductENSBTAG00000015793 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123892
RARGGeneProduct
RFX7GeneProduct
RGS10GeneProduct
RTF1GeneProductENSBTAG00000001671 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137815
SCHIP1GeneProduct
SESN1GeneProduct
SFMBT1GeneProduct
SFRP1GeneProductENSBTAG00000027625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104332
SIAH2GeneProductENSBTAG00000023445 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181788
SLC2A12GeneProduct
SMAD2GeneProductENSBTAG00000039916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175387
SMAD3GeneProductENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166949
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141646
SOX17GeneProductENSBTAG00000005748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164736
SOX21GeneProduct
SOX2GeneProductENSBTAG00000011598 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
SOX7GeneProductENSBTAG00000046258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171056
SP4GeneProduct
STAT1GeneProductENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115415
TAF4BGeneProduct
TAF5GeneProduct
TBX21GeneProductENSBTAG00000014199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073861
TCEAL2GeneProduct
TCF4GeneProduct
TCF7GeneProductENSBTAG00000001002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081059
TCF7L1GeneProduct
TET1GeneProduct
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
TNRC6CGeneProductENSBTAG00000018658 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078687
TOXGeneProduct
TOX3GeneProduct
TRERF1GeneProduct
TRIM5GeneProduct
TRIM71GeneProduct
UBR5GeneProduct
VAV3GeneProduct
WDFY2GeneProduct
WDHD1GeneProduct
WNT3GeneProductENSBTAG00000016012 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108379
WNT8AGeneProductENSBTAG00000005570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000061492
WWC1GeneProduct
ZBTB17GeneProduct
ZFHX4GeneProduct
ZIC3GeneProduct
ZIC5GeneProduct
ZNF281GeneProduct
ZNF462GeneProduct
bta-mir-141GeneProductENSBTAG00000036410 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207708
bta-mir-375GeneProductENSBTAG00000029763 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198973

Annotated Interactions

No annotated interactions
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