TP53 Network (Bos taurus)

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356142Grown arrest and apoptosisDifferent isoforms of the proteinReduces transcriptional activity but does not induce degradationGrown arrest and apoptosisApoptosisTP73TP73MDM2SUMO1GADD45APMAIP1MYCTP63BID2TP73TP73TP63TP63TP63TP73BBC3OTX2TP73ABL1IGFBP-3BAXTP63BOKTP63BCL2TP53TNFSF10CDKN1ATP73CDKN2ATP73ATMTP63


Description

P53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high level of sequence homology in its DNA binding domain. The complexity of the family has been enriched by the alternatively spliced forms of the genes. At present pathway, the alternatively spliced forms of p63 and p73 and how they interact with p53 are shown . However, little is known about the transcriptional regulation of p53 family members. Further studies will tell us whether the three genes of the family also share others regulatory activities.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1742(71700) with a 90.0% conversion rate.

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Bibliography

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  1. Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M; ''Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines.''; Mol Cancer Res, 2010 PubMed Europe PMC
  2. Shaul Y; ''c-Abl: activation and nuclear targets.''; Cell Death Differ, 2000 PubMed Europe PMC
  3. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D; ''p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.''; Nature, 1999 PubMed Europe PMC
  4. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S; ''Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.''; Cancer Res, 2002 PubMed Europe PMC
  5. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F; ''p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.''; Mol Cell, 1998 PubMed Europe PMC
  6. Dohn M, Zhang S, Chen X; ''p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes.''; Oncogene, 2001 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
80865view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
ATMGeneProductENSBTAG00000003111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149311
BAXGeneProductENSBTAG00000013340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:581
BBC3GeneProduct
BCL2GeneProductENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171791
BID2GeneProductENSBTAG00000013988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000015475
BOKGeneProductENSBTAG00000008711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:666
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124762
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
GADD45AGeneProductENSBTAG00000013860 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1647
IGFBP-3GeneProduct
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135679
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
OTX2GeneProductENSBTAG00000014741 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165588
PMAIP1GeneProduct
SUMO1ProteinENSBTAG00000009859 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7341
TNFSF10GeneProductENSBTAG00000018994 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8743
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
TP63ProteinENSBTAG00000015460 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9H3D4
TP73GeneProductENSBTAG00000005812 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7161

Annotated Interactions

No annotated interactions
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