Sulfation Biotransformation Reaction (Bos taurus)

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1-3sulfurylasemodification of Cys83 in SULT1E1PAPS synthesis (co-substrate)APS kinaseSULT1C2NADP+SULT1E1SULT2A1PPiGlutathione (reduced)PAPSS2NADPHSULT1A1SULT6B1PAPSS1GSRSulfateSubstrate sulfatePAPSATPSULT1A1SULT4A1ADPSULT1A1G6PDSULT2B1PAPGlutathione (oxidized)SULT1C3SULT1C2APSGPXATPSubstrateSulfotransferaseSULT1C4SULT1A1SULT1B1


Description

Metabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, the compound is modificated via oxidation, reduction, hydrolysis, or other minor reactions, to reveal a reactive group to which a conjugation molecule can react to. In phase II, a small conjugation molecule reacts with the phase I modified molecule, producing a much more water-soluble molecule that can be excreted more easily. Sulfation is a phase II biotransformation reaction in which sulfate acts as a conjugation molecule and binds to a substrate via the catalysis of sulfotransferases. Sulfate is first combined with ATP molecules to form PAPS via the dual function enzymes PAPSS1 and PAPSS2 consisting of a sulfurylase domain and an APS kinase domain. From PAPS the sulfate group is transferred to the actual substrate via the action of sulfotransferases, resulting in a sulfated substrate and the sulfate-lacking PAP.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP692(69031) with a 90.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Gamage N, Barnett A, Hempel N, Duggleby RG, Windmill KF, Martin JL, McManus ME; ''Human sulfotransferases and their role in chemical metabolism.''; Toxicol Sci, 2006 PubMed Europe PMC
  2. Coughtrie MW, Johnston LE; ''Interactions between dietary chemicals and human sulfotransferases-molecular mechanisms and clinical significance.''; Drug Metab Dispos, 2001 PubMed Europe PMC
  3. Coughtrie MW; ''Sulfation through the looking glass--recent advances in sulfotransferase research for the curious.''; Pharmacogenomics J, 2002 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
106020view11:54, 16 August 2019MaintBotHMDB identifier normalization
80849view15:28, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
APSMetaboliteHMDB01003 (HMDB)
ATPMetaboliteHMDB00538 (HMDB)
G6PDGeneProductENSBTAG00000019512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160211
GPXGeneProduct
GSRGeneProductENSBTAG00000007115 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104687
Glutathione (oxidized)MetaboliteHMDB03337 (HMDB)
Glutathione (reduced)MetaboliteHMDB00125 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
PAPMetaboliteHMDB00061 (HMDB)
PAPSMetaboliteHMDB01134 (HMDB)
PAPSS1GeneProductENSBTAG00000012961 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138801
PAPSS2GeneProductENSBTAG00000003196 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198682
PPiMetabolite
SULT1A1GeneProductENSBTAG00000008635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213648
SULT1B1GeneProductENSBTAG00000001249 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173597
SULT1C2GeneProductENSBTAG00000032051 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198075
SULT1C2GeneProductENSBTAG00000038369 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198203
SULT1C3GeneProductENSBTAG00000002803 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196228
SULT1C4GeneProductENSBTAG00000032051 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27233
SULT1E1GeneProductENSBTAG00000011952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SULT2A1GeneProductENSBTAG00000039971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105398
SULT2B1GeneProductENSBTAG00000045498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000088002
SULT4A1GeneProductENSBTAG00000006273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130540
SULT6B1GeneProductENSBTAG00000008707 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138068
SubstrateMetabolite
Substrate sulfateMetabolite
SulfateMetaboliteHMDB01448 (HMDB)
SulfotransferaseGeneProduct

Annotated Interactions

No annotated interactions
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