Sphingolipid Metabolism (Bos taurus)

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1, 2(DH)Cer synthasesDHLacCerSMase2CERS6DihydroceramideGAL3ST1PPAP2ASphingosineC16:0-alASAH3Sa 1-phosphateDHGalCerDHCer1PSGMS2Palmityl-CoASPHK1LASS5Sphingosine 1-phosphateB4GALT6SPHK1CeramidesASAH1SphinganineDES1LASS3ASAH3DES2SGPP2DHGlcCerSERINC1C16:1-alDHSTDHSMSerineKDSRSPTLC13-ketosphinganineASAH1CERKSMase1CERTPPAP2ASGMS1SGPP2SPHK2SaP lyase1SPTLC2ASAH2GalCer SynthaseGlcCer SynthaseCERS4SPHK2CERS2Ethanolamine phosphateASAH2SPTLC3SoP lyase1Cer1PCERTGalCerSMase2SphingomyelinSGMS2GlcCerSGMS1LactosylceramideGAL3ST1CERKSMase1SulfatideGalCer SynthaseGlcCer SynthaseB4GALT6


Description

The sphingolipid metabolites and genes (with the gene abbreviations shown in boxes, or enzyme names where gene names are ambiguous) are given for the condensation of serine and palmitoyl-CoA to form 3-ketosphinganine (3-ketoSa) by serine palmitoyltransferase, which is reduced to sphinganine (Sa), acylated to dihydroceramides, DHCer, by (DH)Cer synthases, and incorporated into more complex DH-sphingolipids (the 1-phosphate, DHCerP, sphingomyelins, DHSM, glucosylceramides, DHGlcCer, galactosylceramides, DHGalCer, lactosylceramides, DHLacCer, and sulfatides, or desaturated to Cer followed by headgroup addition. Also included are a number of the catabolic genes, e.g., sphingomyelinases, SMases, ceramidases, ASAH, sphingosine kinases, for the formation of sphinganine 1-phosphate (Sa1P) and sphingosine 1-phosphate (So1P), and phosphatases for the reverse reaction and the lyase that cleaves sphingoid base 1-phosphates to ethanolamine phosphate (EP), hexadecanal (C16:0al) and hexadecenal (C16:1al).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1422(79871) with a 66.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Merrill AH Jr, Stokes TH, Momin A, Park H, Portz BJ, Kelly S, Wang E, Sullards MC, Wang MD; ''Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease.''; J Lipid Res, 2009 PubMed
  2. Merrill AH Jr, Wang MD, Park M, Sullards MC; ''(Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology.''; Trends Biochem Sci, 2007 PubMed

History

CompareRevisionActionTimeUserComment
80844view15:28, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3-ketosphinganineMetabolite
ASAH1GeneProductENSBTAG00000011257 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:427
ASAH2GeneProductENSBTAG00000003529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56624
ASAH3GeneProduct
B4GALT6GeneProductENSBTAG00000044063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9331
C16:0-alMetabolite
C16:1-alMetabolite
CERKGeneProductENSBTAG00000046654 (Ensembl)
  • 2.7.1.138
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64781
CERS2GeneProductENSBTAG00000000099 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29956
CERS4GeneProductENSBTAG00000003434 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79603
CERS6GeneProductENSBTAG00000044179 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:253782
CERTGeneProduct
Cer1PMetabolite
CeramidesMetaboliteHMDB04949 (HMDB)
DES1GeneProduct
DES2GeneProduct
DHCer1PMetabolite
DHGalCerMetabolite
DHGlcCerMetabolite
DHLacCerMetabolite
DHSMMetabolite
DHSTMetabolite
DihydroceramideMetaboliteHMDB06752 (HMDB)
Ethanolamine phosphateMetaboliteCHEBI:17553 (ChEBI)
GAL3ST1GeneProductENSBTAG00000014232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9514
GalCer SynthaseGeneProduct
GalCerMetaboliteHMDB00140 (HMDB)
GlcCer SynthaseGeneProduct
GlcCerMetaboliteHMDB00140 (HMDB)
KDSRGeneProductENSBTAG00000007723 (Ensembl)
  • 1.1.1.102
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2531
LASS3GeneProductENSBTAG00000006987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:204219
LASS5GeneProductENSBTAG00000017395 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:91012
LactosylceramideMetaboliteHMDB06750 (HMDB)
PPAP2AGeneProductENSBTAG00000010526 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8611
Palmityl-CoAMetaboliteHMDB01338 (HMDB)
SERINC1GeneProductENSBTAG00000000019 (Ensembl)
  • 2.3.1.24
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57515
SGMS1ProteinENSBTAG00000011748 (Ensembl)
  • 2.7.8.3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86VZ5
SGMS2ProteinENSBTAG00000016805 (Ensembl)
  • 2.7.8.3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8NHU3
SGPP2GeneProductENSBTAG00000046649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:130367
SMase1GeneProduct
SMase2GeneProduct
SPHK1GeneProductENSBTAG00000008507 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8877
SPHK2GeneProductENSBTAG00000009872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56848
SPTLC1GeneProductENSBTAG00000002220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10558
SPTLC2GeneProductENSBTAG00000020480 (Ensembl)
  • 2.3.1.50
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9517
SPTLC3GeneProductENSBTAG00000014252 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55304
Sa 1-phosphateMetaboliteHMDB01383 (HMDB)
SaP lyase1GeneProduct4.1.2.27
SerineMetaboliteHMDB00187 (HMDB)
SoP lyase1GeneProduct4.1.2.27
SphinganineMetaboliteHMDB00269 (HMDB)
SphingomyelinMetaboliteHMDB01348 (HMDB)
Sphingosine 1-phosphateMetaboliteHMDB00277 (HMDB)
SphingosineMetaboliteHMDB00252 (HMDB)
SulfatideMetaboliteHMDB00024 (HMDB)

Annotated Interactions

No annotated interactions
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