Thyroid Stimulating Hormone (TSH) signaling pathway (Bos taurus)

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CCND3CCND3MAP2K1PMAPK3PPIK3R2cAMPIP3DAGPKAPIP2PIP3LigandmRNACYProteinNUEnzyme ComplexReceptorCell proliferationTSH Signal Transduction PathwayFOSHRASCGARAF1MYCKCNIP3TTF2EGR1GNG2E2F1STAT1TSHBBRAFSCRIBTTF1GNB1PAX8JUNPTSHRSTAT3PPDPK1PPIK3CAPIK3R1CDK2PPSRCpMAP2K3PMAP2K6AKT1PPRBL2RPS6KB1PMAPK1PRB1PCREB1PDE4DPPGNAI1GTPGNA13GTPGNAI2GTPGNA12GNAO1GTPGTPGNAQGNAI3GTPGTPMYL12BRALGDSDePGNASGTPJAK2PJAK1PRPS6MTORPADCY2ADCY3CDK2PCDK4PRPS6KA1PPRKCSHPLCB1RAP1BRAP1AGTPGTPIGF1RCCNE1MAPK14CDKN1BPCCND3CDK4PRAP1GAPPNUCYPKANUCYSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeAPEX1APEX1NUCYProteinProtein


Description

Human thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-thyroid by stimulating production and secretion of the thyroid hormone from the thyroid gland. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.


NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2032(79960) with a 97.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
96289view15:01, 7 March 2018Fehrhartconnected lines
89825view12:00, 6 October 2016MkutmonOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
89824view11:59, 6 October 2016MkutmonModified description
89819view11:54, 6 October 2016MkutmonModified title
80831view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY2GeneProductENSBTAG00000019210 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
ADCY3GeneProductENSBTAG00000018705 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
APEX1GeneProductENSBTAG00000002745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:328
BRAFGeneProductENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCNE1GeneProductENSBTAG00000004735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CGAGeneProductENSBTAG00000016138 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1081
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
E2F1RnaENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
EGR1RnaENSBTAG00000010069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1958
FOSRnaENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GNA12GeneProductENSBTAG00000017871 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768
GNA13GeneProductENSBTAG00000046174 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672
GNAI1GeneProductENSBTAG00000002714 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770
GNAI2GeneProductENSBTAG00000020645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771
GNAI3GeneProductENSBTAG00000013016 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773
GNAO1GeneProductENSBTAG00000003794 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775
GNAQGeneProductENSBTAG00000009789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNASGeneProductENSBTAG00000017475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GNB1GeneProductENSBTAG00000000215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
GNG2GeneProductENSBTAG00000003043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54331
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IGF1RGeneProductENSBTAG00000021527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
JAK1GeneProductENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2GeneProductENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JUNRnaENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KCNIP3GeneProduct
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
MYCRnaENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
MYL12BGeneProductENSBTAG00000026266 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:103910
PAX8RnaENSBTAG00000019354 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7849
PDE4DGeneProductENSBTAG00000000494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
PDPK1GeneProductENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PLCB1GeneProductENSBTAG00000008338 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23236
PRKCSHGeneProductENSBTAG00000017490 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5337
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RALGDSGeneProductENSBTAG00000004194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5900
RAP1AGeneProductENSBTAG00000014710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAP1BGeneProductENSBTAG00000008967 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
RAP1GAPGeneProductENSBTAG00000008952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5909
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RBL2GeneProductENSBTAG00000016243 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
RPS6GeneProductENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KA1GeneProductENSBTAG00000014447 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
RPS6KB1GeneProductENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
SCRIBGeneProductENSBTAG00000008421 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23513
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1GeneProductENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3GeneProductENSBTAG00000021523 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
TSHBGeneProductENSBTAG00000006295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7252
TSHRGeneProductENSBTAG00000017489 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7253
TTF1RnaENSBTAG00000018710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7270
TTF2RnaENSBTAG00000015392 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8458

Annotated Interactions

No annotated interactions
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