Aryl Hydrocarbon Receptor (Bos taurus)

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23754, 5537, 51282657225, 27, 438143033301711, 46STAT152CyNuHSP902ActivationTCDD55CyNuNEDD8SUMO7CyNuCyNuProteinProteinNucleusRETNFE2L2CDKN1BRB1NQO1VEGFAHSP90AA1KLF6PLAGL1ARNTXRETCDDPAHCYP1A1DRE regionproliferation and tumorigenesis EGFRCCL1EBNA-3ESR1Calcium ChannelAIPEP3002615, 54, 5510, 41P3119L341447, 5713, 49AIP5, 6, 453238227, 29, 5650AHRAIP2, 35AHRAHRHSP90AA155HSP90AA116, 4425MYC18TATAEGFR PathwayTNF43CDC37SRC51PRAF1PMAP2K1PMAPK1PGHS-28PSRC1RELANFKB1RELANFKB1EP30042PSRC1AngiogenesisNCOA7NRIP1CYP1A1CD36LPLNFE2L240FGF21HPGDSGCLCOxidative StressNRIP1NF1NCOA7NCOR24CYP1A22448CYP1B1Estrogen Metabolism and modulation of Estrogen receptor signalling9, 39Enzyme ComplexProteinReceptorLigandmRNASmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeCDKN1A12, 20CDK2RB1E2F1Cell cycle inhibitionDetoxification of Xenobiotics and metabolism of xenobioticsCell SurvivalAHRREP30053FAS/ FAS-L (Apoptosis)NRASHRASKRASTCDDPAH7, 29, 5610, 411Cell Survival


Description

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity.

AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2586(79995) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  49. Klinge CM, Kaur K, Swanson HI; ''The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.''; Arch Biochem Biophys, 2000 PubMed
  50. N'Diaye M, Le Ferrec E, Lagadic-Gossmann D, Corre S, Gilot D, Lecureur V, Monteiro P, Rauch C, Galibert MD, Fardel O; ''Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.''; J Biol Chem, 2006 PubMed
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History

CompareRevisionActionTimeUserComment
89410view20:18, 10 September 2016AlexanderPicoOntology Term : 'signaling pathway' added !
89133view21:49, 22 August 2016AriuttaOntology Term : 'regulatory pathway' added !
85345view10:13, 9 May 2016EgonwReplaced a mim-conversion with Arrow.
80830view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProductENSBTAG00000007746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196
AHRRGeneProductENSBTAG00000026527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57491
AIPGeneProductENSBTAG00000010478 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110711
ARNTGeneProductENSBTAG00000021037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:405
AngiogenesisPathway
CCL1GeneProductENSBTAG00000008832 (Ensembl)
  • PMID: 16679317 PAHs induce expression of the chemokine CCL1 in an AhR- and calcium-dependent manner.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6346
CD36GeneProductENSBTAG00000014220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:948
CDC37GeneProductENSBTAG00000011699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11140
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CYP1A1ProteinENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1543
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1544
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1545
Calcium Channel
Cell SurvivalPathway
Cell Survival Pathway
Cell cycle inhibitionPathway
DRE regionComplex
Detoxification of Xenobiotics and metabolism of xenobiotics Pathway
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
EBNA-3Protein
EGFR Pathway
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
EP300ProteinENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
ESR1ProteinENSBTAG00000007159 (Ensembl)
  • Estrogen Receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2099
Estrogen Metabolism and modulation of Estrogen receptor signallingPathway
FAS/ FAS-L (Apoptosis)Pathway
FGF21ProteinENSBTAG00000011624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26291
GCLCProteinENSBTAG00000015571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
HPGDSProteinENSBTAG00000017073 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27306
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174775
HSP90AA1GeneProductENSBTAG00000006270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3320
KLF6GeneProductENSBTAG00000015188 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1316
KRASGeneProduct
LPLProteinENSBTAG00000012855 (Ensembl)
  • lipoprotein lipase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MYCProteinENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NCOA7ProteinENSBTAG00000011911 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:135112
NCOR2ProteinENSBTAG00000024603 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9612
NF1ProteinENSBTAG00000011829 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4763
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NQO1ProteinENSBTAG00000020632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1728
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213281
NRIP1ProteinENSBTAG00000047293 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8204
Oxidative Stress Pathway
PAHMetabolite33848 (ChEBI)
PGHS-2GeneProductENSBTAG00000014127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
PLAGL1ProteinENSBTAG00000026523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5325
PSRC1GeneProductENSBTAG00000018806 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84722
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RETProteinENSBTAG00000000570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5979
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
TATAComplex
TCDDMetabolite28119 (ChEBI)
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
XRExenobiotic responsive element
proliferation and tumorigenesis Pathway

Annotated Interactions

No annotated interactions
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