Interferon type I signaling pathways (Bos taurus)

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8TRANSLATION INITIATIONCREBISREGASType I IFNs2, 13, 14, 27, 3051Gamma Activated SequenceNegative regulators of IFN transcriptionPI3K complexInterferon Stimulated Response ElementISGF3 complexGAF complexmTORC1Negative regulators of IFN signalingType I IFN Receptor ComplexPIK3R1IFNAR1FYNGDPSOCS3IFNAR2MAPK14MAP3K1PTPN11SOCS1MAP2K6IRS1PIK3CDRPS6KB1CREB1STAT5AIRS2PRMT1STAT1IFNAR2CRKRAC1MAPKAP1STAT3EIF4EBP1MAP2K3STAT4VAV1PIAS1RPS6KA4PTPRCPDCD4EIF4EGNB2L1EIF4BZAP70RAP1ACRKLJAK1RAPGEF1IRF9TYK2CBLPTPN6LCKRPTORRELSTAT2STAT4MTORCRKLSTAT2GTPRPS6IFNAR2STAT1GAB2PIAS3MLST8MTORSTAT1RPS6KA5EIF4A1264, 16211523293, 12, 257, 2812919610, 17, 3124182211STAT3RAC1PPPPPPPPPPPPPIK3R2PPPPNFkBSTAT1STAT3STAT3STAT1STAT2PPPPPPPTrans-Signalling


Description

The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways.

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HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP585(80201) with a 95.0% conversion rate.

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Bibliography

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  1. Uddin S, Fish EN, Sher D, Gardziola C, Colamonici OR, Kellum M, Pitha PM, White MF, Platanias LC; ''The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors.''; Blood, 1997 PubMed
  2. Fu XY; ''A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s).''; Cell, 1992 PubMed
  3. Colamonici OR, Domanski P; ''Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21.''; J Biol Chem, 1993 PubMed
  4. Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, Pellegrini S, White MF, Kerr IM; ''Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.''; J Biol Chem, 1997 PubMed
  5. Fish EN, Uddin S, Korkmaz M, Majchrzak B, Druker BJ, Platanias LC; ''Activation of a CrkL-stat5 signaling complex by type I interferons.''; J Biol Chem, 1999 PubMed
  6. Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC; ''Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase.''; J Biol Chem, 1995 PubMed
  7. You M, Yu DH, Feng GS; ''Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.''; Mol Cell Biol, 1999 PubMed
  8. Uddin S, Majchrzak B, Woodson J, Arunkumar P, Alsayed Y, Pine R, Young PR, Fish EN, Platanias LC; ''Activation of the p38 mitogen-activated protein kinase by type I interferons.''; J Biol Chem, 1999 PubMed
  9. Yan H, Krishnan K, Lim JT, Contillo LG, Krolewski JJ; ''Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction.''; Mol Cell Biol, 1996 PubMed
  10. Owczarek CM, Hwang SY, Holland KA, Gulluyan LM, Tavaria M, Weaver B, Reich NC, Kola I, Hertzog PJ; ''Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2.''; J Biol Chem, 1997 PubMed
  11. Baychelier F, Nardeux PC, Cajean-Feroldi C, Ermonval M, Guymarho J, Tovey MG, Eid P; ''Involvement of the Gab2 scaffolding adapter in type I interferon signalling.''; Cell Signal, 2007 PubMed
  12. Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR; ''Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.''; J Biol Chem, 1995 PubMed
  13. Gutch MJ, Daly C, Reich NC; ''Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor.''; Proc Natl Acad Sci U S A, 1992 PubMed
  14. Darnell JE Jr; ''STATs and gene regulation.''; Science, 1997 PubMed
  15. Song MM, Shuai K; ''The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities.''; J Biol Chem, 1998 PubMed
  16. Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C; ''The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.''; Nature, 1993 PubMed
  17. Novick D, Cohen B, Rubinstein M; ''Soluble interferon-alpha receptor molecules are present in body fluids.''; FEBS Lett, 1992 PubMed
  18. Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC; ''Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.''; Biochem Biophys Res Commun, 1996 PubMed
  19. Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K; ''Inhibition of Stat1-mediated gene activation by PIAS1.''; Proc Natl Acad Sci U S A, 1998 PubMed
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  22. Farrar JD, Smith JD, Murphy TL, Murphy KM; ''Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2.''; J Biol Chem, 2000 PubMed
  23. Ahmad S, Alsayed YM, Druker BJ, Platanias LC; ''The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein.''; J Biol Chem, 1997 PubMed
  24. Uzé G, Lutfalla G, Gresser I; ''Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA.''; Cell, 1990 PubMed
  25. Novick D, Cohen B, Rubinstein M; ''The human interferon alpha/beta receptor: characterization and molecular cloning.''; Cell, 1994 PubMed
  26. Platanias LC, Uddin S, Bruno E, Korkmaz M, Ahmad S, Alsayed Y, Van Den Berg D, Druker BJ, Wickrema A, Hoffman R; ''CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors.''; Exp Hematol, 1999 PubMed
  27. Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA; ''Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.''; EMBO J, 1994 PubMed
  28. David M, Chen HE, Goelz S, Larner AC, Neel BG; ''Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.''; Mol Cell Biol, 1995 PubMed
  29. Platanias LC, Uddin S, Yetter A, Sun XJ, White MF; ''The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.''; J Biol Chem, 1996 PubMed
  30. Schindler C, Shuai K, Prezioso VR, Darnell JE Jr; ''Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.''; Science, 1992 PubMed
  31. Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ; ''Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.''; J Immunol, 2014 PubMed
  32. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H; ''MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.''; Oncogene, 2008 PubMed

History

CompareRevisionActionTimeUserComment
85346view10:14, 9 May 2016EgonwReplaced a mim-conversion with Arrow.
80811view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CBLProteinENSBTAG00000006817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867
CREB1ProteinENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CRKGeneProductENSBTAG00000005665 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
CRKLProteinENSBTAG00000045548 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
EIF4A1ProteinENSBTAG00000000132 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1973
EIF4BProteinENSBTAG00000006883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1975
EIF4EBP1ProteinENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
EIF4EProteinENSBTAG00000009522 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1977
FYNGeneProductENSBTAG00000011851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GAB2Protein
GDPMetabolite17552 (ChEBI)
GNB2L1ProteinENSBTAG00000019648 (Ensembl)
  • RACK1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10399
GTPMetabolite15996 (ChEBI)
IFNAR1ProteinENSBTAG00000021819 (Ensembl)
  • INTERFERON RECEPTOR
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3454
IFNAR2ProteinENSBTAG00000015212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455
IRF9ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000005816;En:ENSBTAG00000005815;
IRS1ProteinENSBTAG00000021308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667
IRS2ProteinENSBTAG00000012019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
JAK1GeneProductENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
LCKGeneProductENSBTAG00000012695 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932
MAP2K3ProteinENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K6ProteinENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAP3K1ProteinENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPKAP1ProteinENSBTAG00000010271 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79109
MLST8ProteinENSBTAG00000009928 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64223
MTORProteinENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
PDCD4ProteinENSBTAG00000019434 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27250
PIAS1GeneProductENSBTAG00000005564 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8554
PIAS3GeneProductENSBTAG00000021634 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10401
PIK3CDProteinENSBTAG00000018984 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PRMT1ProteinENSBTAG00000001357 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276
PTPN11GeneProductENSBTAG00000002048 (Ensembl)
  • SHP2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
PTPN6GeneProductENSBTAG00000020294 (Ensembl)
  • SHP1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5777
PTPRCGeneProductENSBTAG00000023144 (Ensembl)
  • CD45
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788
RAC1ProteinENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAP1AProteinENSBTAG00000014710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAPGEF1ProteinENSBTAG00000020791 (Ensembl)
  • C3G
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
RELProteinENSBTAG00000015386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966
RPS6ProteinENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KA4ProteinENSBTAG00000039153 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8986
RPS6KA5ProteinENSBTAG00000010906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
RPS6KB1ProteinENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
RPTORProteinENSBTAG00000002883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57521
SOCS1ProteinENSBTAG00000004386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
SOCS3ProteinENSBTAG00000008441 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT2ProteinENSBTAG00000004380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT4ProteinENSBTAG00000046699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775
STAT5AProteinENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
TYK2ProteinENSBTAG00000011698 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7297
VAV1ProteinENSBTAG00000039160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409
ZAP70GeneProductENSBTAG00000005892 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7535

Annotated Interactions

No annotated interactions
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