Ectoderm Differentiation (Bos taurus)

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271936548NucleusPAX6 TargetsNUMA1FOXA2SOCS2GLI3TNFRSF11BCTBP1ZFHX4BMPR1ARAB8BZBTB2SPRY2POU2F2PTPN13ZBTB16NARS2CELSR2ZBTB7BPHF8GREB1SMURF1GLB1KRT6AMZF1ROR2ANKS1BSGSM3PTPRBPRKAG2ARHGEF9BMP4PODXLRHPN1FGFR2OGTKIFC3ZNF219PDE7AVAX2NLKARHGDIGTTC14TSKUPGM1SMAD4STC1PAX3CDONSCHIP1KIAA1161PPFIBP2ARHGAP15ASTN1RIT1CROCCP2DMDCCDC130SNCAHMGB2ELOVL2FYNBAZ1AZFHX4CCDC88CAESZBTB2AHI1TBL1XWDR44FZD5MIR486ABCC4NLKCDH6MYCPI4KAPAX6EDAJAKMIP1PPARDHDAC6CTNND2PAN2SORCS1MYCLDB2HDAC10SERPINB6GATA6LHX1GAS2L1RRBP1CAP2FOXL1EDA2RPLXNA2GRAMD1BELOVL4CTNNB1NR2F2bta-mir-34cCLDN11CTNNA2SDCBPNLGN1ARXARHGDIGCCL2FZD4STX16ZBTB2MECP2BOCbta-mir-361KCNK10SHHHIST1H2BHCDH8UBFCLVS1PLCXD3ST8SIA4C1GALT1JUPTSC22D1RGMAFZD8BCAS3TCF3SKILPIM1EDANFATC1bta-mir-15bNF2TRIM33TOX3TRPM2WNT1MKS1LY6ETCF7L1HESX1SIX6ARHGAP10MAFBTFAP2C TargetsTFAP2CMIR124 Targets(Induced in Endoderm)MIR124 Targets(Induced in Mesoderm)MIR124-1SOX2TFAP2AAdditional Predicted Key Ectoderm TFsZBTB2FHL2SKILBCORMIR15B Targets(Induced in Stem Cells)MIR15B Targets(Induced in Endoderm)MIR34C Targets(Induced in Stem Cells)MIR34C Targets(Induced in Endoderm)MesodermInduction


Description

Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2858(80104) with a 93.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. ''Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis''; , PubMed Europe PMC
  2. ''Hedgehog and Gli signaling in embryonic mammary gland development.''; , PubMed Europe PMC
  3. ''HESX1- and TCF3-mediated repression of Wnt/خ²-catenin targets is required for normal development of the anterior forebrain''; , PubMed Europe PMC
  4. ''Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from embryonic stem cells.''; , PubMed Europe PMC
  5. Van Hateren, N., Shenton, T., Borycki, A.-G; ''Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development ''; , 2006 PubMed Europe PMC
  6. ''Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway.''; , PubMed Europe PMC
  7. ''Beyond cell adhesion: the role of armadillo proteins in the heart.''; , PubMed Europe PMC
  8. ''Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.''; , PubMed Europe PMC
  9. ''Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development''; , PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
87934view13:03, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80803view15:26, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC4GeneProductENSBTAG00000046611 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125257
AESGeneProductENSBTAG00000031363 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104964
AHI1ENSG00000135541 (Ensembl)
ANKS1BGeneProductENSBTAG00000013979 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185046
ARHGAP10ENSG00000071205 (Ensembl)
ARHGAP15ENSG00000075884 (Ensembl)
ARHGDIGGeneProductENSBTAG00000027854 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242173
ARHGEF9ENSG00000131089 (Ensembl)
ARXGeneProduct
ASTN1GeneProductENSBTAG00000012953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152092
BAZ1AGeneProductENSBTAG00000020164 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11177
BCAS3GeneProductENSBTAG00000002663 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141376
BCORGeneProductENSBTAG00000047339 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54880
BMP4ENSG00000125378 (Ensembl)
BMPR1AENSG00000107779 (Ensembl)
BOCENSG00000144857 (Ensembl)
C1GALT1GeneProductENSBTAG00000004995 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106392
CAP2GeneProductENSBTAG00000016924 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112186
CCDC130ENSG00000104957 (Ensembl)
CCDC88CENSG00000015133 (Ensembl)
CCL2GeneProductENSBTAG00000037811 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108691
CDH6ENSG00000113361 (Ensembl)
CDH8ENSG00000150394 (Ensembl)
CDONENSG00000064309 (Ensembl)
CELSR2GeneProductENSBTAG00000018804 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143126
CLDN11GeneProductENSBTAG00000019060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000013297
CLVS1GeneProductENSBTAG00000043978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177182
CROCCP2GeneProduct
CTBP1ENSG00000159692 (Ensembl)
CTNNA2ENSG00000066032 (Ensembl)
CTNNB1ENSG00000168036 (Ensembl)
CTNND2ENSG00000169862 (Ensembl)
DMDGeneProductENSBTAG00000008248 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198947
EDA2RENSG00000131080 (Ensembl)
EDAGeneProductENSBTAG00000012543 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158813
EDAENSG00000158813 (Ensembl)
ELOVL2GeneProductENSBTAG00000002497 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197977
ELOVL4GeneProductENSBTAG00000015498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118402
FGFR2ENSG00000066468 (Ensembl)
FHL2GeneProductENSBTAG00000001086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2274
FOXA2ENSG00000125798 (Ensembl)
FOXL1GeneProductENSBTAG00000040605 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176678
FYNENSG00000010810 (Ensembl)
FZD4GeneProductENSBTAG00000040128 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174804
FZD5GeneProductENSBTAG00000020957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163251
FZD8GeneProductENSBTAG00000015072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177283
GAS2L1GeneProductENSBTAG00000012504 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185340
GATA6GeneProductENSBTAG00000005734 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141448
GLB1GeneProductENSBTAG00000015254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170266
GLI3ENSG00000106571 (Ensembl)
GRAMD1BGeneProductENSBTAG00000001410 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023171
GREB1GeneProductENSBTAG00000015402 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196208
HDAC10ENSG00000100429 (Ensembl)
HDAC6ENSG00000094631 (Ensembl)
HESX1GeneProductENSBTAG00000001439 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163666
HIST1H2BHGeneProduct
HMGB2ENSG00000164104 (Ensembl)
JAKMIP1GeneProductENSBTAG00000011170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152969
JUPENSG00000173801 (Ensembl)
KCNK10GeneProductENSBTAG00000019355 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100433
KIAA1161GeneProduct
KIFC3GeneProductENSBTAG00000007181 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140859
KRT6AENSG00000205420 (Ensembl)
LDB2GeneProductENSBTAG00000014058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9079
LHX1ENSG00000132130 (Ensembl)
LY6EGeneProductENSBTAG00000017040 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160932
MAFBGeneProductENSBTAG00000003396 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204103
MECP2GeneProductENSBTAG00000047855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169057
MIR124-1GeneProduct
MIR486GeneProduct
MKS1ENSG00000011143 (Ensembl)
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
MZF1GeneProductENSBTAG00000037581 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099326
NARS2GeneProductENSBTAG00000039943 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137513
NF2ENSG00000186575 (Ensembl)
NFATC1GeneProductENSBTAG00000000656 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131196
NLGN1ENSG00000169760 (Ensembl)
NLKGeneProductENSBTAG00000014825 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087095
NLKENSG00000087095 (Ensembl)
NR2F2ENSG00000185551 (Ensembl)
NUMA1ENSG00000137497 (Ensembl)
OGTENSG00000147162 (Ensembl)
PAN2ENSG00000135473 (Ensembl)
PAX3ENSG00000135903 (Ensembl)
PAX6ENSG00000007372 (Ensembl)
PDE7AENSG00000205268 (Ensembl)
PGM1GeneProductENSBTAG00000019011 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079739
PHF8GeneProductENSBTAG00000013289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172943
PI4KAGeneProductENSBTAG00000013971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241973
PIM1GeneProductENSBTAG00000000396 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5292
PLCXD3GeneProductENSBTAG00000010822 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182836
PLXNA2GeneProductENSBTAG00000001173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076356
PODXLGeneProductENSBTAG00000010452 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128567
POU2F2GeneProductENSBTAG00000008556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000028277
PPARDENSG00000112033 (Ensembl)
PPFIBP2GeneProductENSBTAG00000016140 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166387
PRKAG2GeneProductENSBTAG00000002917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
PTPN13ENSG00000163629 (Ensembl)
PTPRBGeneProductENSBTAG00000015296 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127329
RAB8BENSG00000166128 (Ensembl)
RGMAGeneProductENSBTAG00000018603 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182175
RHPN1GeneProductENSBTAG00000002104 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158106
RIT1ENSG00000143622 (Ensembl)
ROR2GeneProductENSBTAG00000005092 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169071
RRBP1GeneProductENSBTAG00000015438 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125844
SCHIP1ENSG00000151967 (Ensembl)
SDCBPENSG00000137575 (Ensembl)
SERPINB6GeneProductENSBTAG00000025280 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124570
SGSM3ENSG00000100359 (Ensembl)
SHHENSG00000164690 (Ensembl)
SIX6GeneProductENSBTAG00000013035 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184302
SKILGeneProductENSBTAG00000004154 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141646
SMURF1ENSG00000198742 (Ensembl)
SNCAENSG00000145335 (Ensembl)
SOCS2GeneProductENSBTAG00000012007 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120833
SORCS1GeneProductENSBTAG00000007948 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108018
SOX2GeneProductENSBTAG00000011598 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
SPRY2GeneProductENSBTAG00000001774 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136158
ST8SIA4GeneProductENSBTAG00000021445 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113532
STC1GeneProductENSBTAG00000001687 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159167
STX16GeneProductENSBTAG00000003872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124222
TBL1XENSG00000101849 (Ensembl)
TCF3ENSG00000071564 (Ensembl)
TCF7L1GeneProductENSBTAG00000010111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152284
TFAP2AGeneProductENSBTAG00000001250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137203
TFAP2CGeneProductENSBTAG00000002065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087510
TNFRSF11BGeneProductENSBTAG00000007423 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164761
TOX3GeneProductENSBTAG00000000418 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103460
TRIM33GeneProductENSBTAG00000001499 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197323
TRPM2GeneProductENSBTAG00000021901 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142185
TSC22D1ENSG00000102804 (Ensembl)
TSKUGeneProductENSBTAG00000001537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182704
TTC14ENSG00000163728 (Ensembl)
UBFGeneProductENSBTAG00000005067 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7343
VAX2ENSG00000116035 (Ensembl)
WDR44GeneProductENSBTAG00000018697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131725
WNT1ENSG00000125084 (Ensembl)
ZBTB16ENSG00000109906 (Ensembl)
ZBTB2GeneProductENSBTAG00000014790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57621
ZBTB7BENSG00000160685 (Ensembl)
ZFHX4GeneProductENSBTAG00000033268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091656
ZFHX4ENSG00000091656 (Ensembl)
ZNF219GeneProductENSBTAG00000021008 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165804
bta-mir-15bGeneProductENSBTAG00000029929 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207779
bta-mir-34cGeneProductENSBTAG00000029991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562
bta-mir-361GeneProductENSBTAG00000029810 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199051

Annotated Interactions

No annotated interactions
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