Retinoblastoma Gene in Cancer (Bos taurus)

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5641723Rb-E2F complexExamples of RB-E2F Complexes inhibiting E2F-driven gene expressionSKP2POLA1RPA2DNA damage response, signal transduction resulting in induction of apoptosiscell cycle checkpointPRIM1HMGB2ABL1RAF1NPATCDKN1BDNA repairCCNB1CDKN1AE2F1SMC3STMN1PCNATYMSG1/S transition of mitotic cell cycleDCKCCDC6SMC2CDC25BRB1HRMT1L1RPA1CDKN1BRPA3RRM2growth factor activityORC1TP53RFC3POLEMAPK13CCNB2CCNE1BARD1MDM2POLD3MCM7CHEK1MIR29B2RBBP7CCNA2G1/S transition of mitotic cell cycleregulation of cyclin-dependent protein kinase activityTOP2ASMC1ASMARCA2CCNE1ABL1SIN3ACCND3RFC4RFC5TFDP1ANLNmitotic cell cycleG2/M transition of mitotic cell cyclebta-mir-21HLTFMCM3TTKRABIFDNA replicationCDK4JNK cascadeMCM4DNMT1histone H3-K9 methylationCDC7L1MCM7CCND1MYCPOLE2MCM6PRKDCCDK1CDK1DNA replication checkpointWEE1MGC159566RPA1RBBP4RBP1SAP30CCNE2DHFRHMGB1MSH6HDAC1CDC25ACDC45LPLK4MIR29B1H2AFZM/G1 transition of mitotic cell cycleRRM1FAF1CDK2MAP kinase activitySUV39H1CDT1KIF4ARB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F2ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1TP53E2F1E2F3TFDP1G1/S transition of mitotic cell cycleTFDP1E2F1TFDP1E2F2TFDP1E2F1regulation of cyclin-dependent protein kinase activitymitotic spindle organizationTFDP2E2F1TFDP2E2F2TFDP2E2F1RBP1HDAC1TFDP1E2F2RB1RBP1HDAC1TFDP1E2F3RB1RBP1HDAC1TFDP2E2F1RB1RBP1HDAC1TFDP2E2F2RB1RBP1HDAC1TFDP2E2F3RB1RBP1HDAC1TFDP2E2F1RB1E2F2TFDP1RB1E2F3TFDP1RB1CDK6CCND1Examples of RB-E2F Complexes promoting E2F-driven gene expressionRb-E2F complex


Description

Describes the role of retinoblastoma (RB) gene in cancer.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2446(80443) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC
  2. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC
  3. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC
  4. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC
  5. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC
  6. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC
  7. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
98749view01:21, 4 October 2018AlexanderPicoModified title
87640view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
80799view15:26, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
ANLNGeneProductENSBTAG00000009218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54443
BARD1GeneProductENSBTAG00000033690 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:580
CCDC6GeneProductENSBTAG00000003189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8030
CCNA2GeneProductENSBTAG00000004943 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890
CCNB1GeneProductENSBTAG00000014239 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891
CCNB2GeneProductENSBTAG00000005269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCNE1GeneProductENSBTAG00000004735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CCNE2GeneProductENSBTAG00000004906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134
CDC25AGeneProductENSBTAG00000009586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993
CDC25BGeneProductENSBTAG00000008436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
CDC45LGeneProductENSBTAG00000004286 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
CDC7L1GeneProductENSBTAG00000016307 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
CDK1GeneProductENSBTAG00000010109 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDK6GeneProductENSBTAG00000044023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CDT1GeneProductENSBTAG00000000638 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81620
CHEK1GeneProductENSBTAG00000017582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111
DCKGeneProductENSBTAG00000012397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1633
DHFRGeneProductENSBTAG00000007681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1719
DNA damage response, signal transduction resulting in induction of apoptosisPathwayWP707 (WikiPathways)
DNA repairPathwayWP1805 (WikiPathways)
DNA replication checkpointPathway
DNA replicationPathwayWP466 (WikiPathways)
DNMT1GeneProductENSBTAG00000002736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1786
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
E2F2GeneProductENSBTAG00000014400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870
E2F3GeneProductENSBTAG00000021045 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871
FAF1GeneProductENSBTAG00000014482 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124
G1/S transition of mitotic cell cyclePathwayWP45 (WikiPathways)
G2/M transition of mitotic cell cyclePathwayWP1859 (WikiPathways)
H2AFZGeneProductENSBTAG00000004428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3015
HDAC1GeneProductENSBTAG00000012698 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065
HLTFGeneProductENSBTAG00000019704 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6596
HMGB1GeneProductENSBTAG00000014862 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3146
HMGB2GeneProductENSBTAG00000015101 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3148
HRMT1L1GeneProductENSBTAG00000005503 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3275
JNK cascadePathway
KIF4AGeneProductENSBTAG00000012861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:24137
M/G1 transition of mitotic cell cyclePathway
MAP kinase activityPathwayWP382 (WikiPathways)
MAPK13GeneProductENSBTAG00000010007 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5603
MCM3GeneProductENSBTAG00000010721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
MCM4GeneProductENSBTAG00000017021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
MCM6GeneProductENSBTAG00000015172 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
MCM7GeneProductENSBTAG00000030965 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MGC159566GeneProductENSBTAG00000015005 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2189
MIR29B1Rna
MIR29B2Rna
MSH6GeneProductENSBTAG00000001424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2956
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NPATGeneProductENSBTAG00000010286 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4863
ORC1GeneProductENSBTAG00000002719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
PCNAGeneProductENSBTAG00000006065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
PLK4GeneProductENSBTAG00000039552 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10733
POLA1GeneProductENSBTAG00000008170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5422
POLD3GeneProductENSBTAG00000016869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10714
POLE2GeneProductENSBTAG00000004931 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5427
POLEGeneProductENSBTAG00000000590 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5426
PRIM1GeneProductENSBTAG00000044000 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5557
PRKDCGeneProductENSBTAG00000017019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
RABIFGeneProductENSBTAG00000013560 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5877
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RBBP4GeneProductENSBTAG00000005904 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5928
RBBP7GeneProductENSBTAG00000002820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5931
RBP1GeneProductENSBTAG00000020028 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5947
RFC3GeneProductENSBTAG00000010787 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5983
RFC4GeneProductENSBTAG00000014727 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5984
RFC5GeneProductENSBTAG00000007137 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5985
RPA1GeneProductENSBTAG00000009711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117
RPA2ProteinENSBTAG00000006225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6118
RPA3ProteinENSBTAG00000013168 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6119
RRM1GeneProductENSBTAG00000013111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6240
RRM2GeneProductENSBTAG00000008216 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6241
SAP30GeneProductENSBTAG00000015578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8819
SIN3AGeneProductENSBTAG00000009985 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25942
SKP2GeneProductENSBTAG00000013562 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502
SMARCA2GeneProductENSBTAG00000007494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6595
SMC1AGeneProductENSBTAG00000017761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243
SMC2GeneProductENSBTAG00000008772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10592
SMC3GeneProductENSBTAG00000013905 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9126
STMN1GeneProductENSBTAG00000026505 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3925
SUV39H1GeneProductENSBTAG00000004706 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6839
TFDP1GeneProductENSBTAG00000019645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027
TFDP2GeneProductENSBTAG00000006222 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7029
TOP2AGeneProductENSBTAG00000019262 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7153
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
TTKGeneProductENSBTAG00000005456 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7272
TYMSGeneProductENSBTAG00000007003 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7298
WEE1GeneProductENSBTAG00000005278 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465
ZNF655Protein
bta-mir-21RnaENSBTAG00000029897 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004
cell cycle checkpointPathway
growth factor activityPathway
histone H3-K9 methylationPathway
mitotic cell cyclePathwayWP179 (WikiPathways)
mitotic spindle organizationPathway
regulation of cyclin-dependent protein kinase activityPathway

Annotated Interactions

No annotated interactions
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