SREBP signalling (Bos taurus)

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ERNucleus30298, 103938COPII coated vesicleLipogenic enzymesGolgi 11Cholesterol synthesisUp regulationPositive effectNegative effectExact mechanism unknownstimulationCatalysisTranscription-TranslationCofactorSRELegendInhibitionAMPKCholesterol efflux Cleavage19PRKAB1PRKAA1InsulinRNF139PRKAA2SREBF2OxysterolsPRKAG2CDK8CATHL3FGF21GSK3APRKAB2SCAPbta-mir-33aNFYAPUFAsKPNB1PRKAG1LPIN1RBP4PRKAG3HMGCRINSIG1MTORAMFRATF6bta-mir-33bUFAsNR1H2CholesterolGlucosePIK3CAPRKACASREBF1SIRT1GlutamineAKT1MBTPS123, 32, 413429, 25618442117, 204SCAP5144227361, 2273735, 401528426SCAPINSIG2INSIG1INSIG2SREBF113, 24SREBF2SREBF1SREBF2SREBF1SAR1ASCAPSREBF2SREBF1SAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBF1SAR1BSEC31ASEC31BMBTPS231SCAPSREBF2SREBF1SREBF1GeneSRESREBF2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREB1SP133NFYACREB1SP1YY1YY112, 43PPARGC1B45MED1516MED15LSSHMGCS1MVDIDI1FDPSFDFT1SQLECYP51A1LPLLDLRSCARB1ACACAGPAMFASNDBIACLYMDH1PPARGACSS1SCDFatty aciddegradationFatty acid synthesisSIRT1INSIG13INSIG2SREBF2SREBF1


Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1982(79943) with a 99.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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80779view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSBTAG00000017567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000278540
ACLYGeneProductENSBTAG00000016740 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131473
ACSS1GeneProductENSBTAG00000004281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154930
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
AMFRGeneProductENSBTAG00000003798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159461
ATF6GeneProductENSBTAG00000005227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118217
CATHL3GeneProductENSBTAG00000031599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164047
CDK8GeneProductENSBTAG00000016737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132964
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118260
CYP51A1GeneProductENSBTAG00000001992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630
CholesterolMetaboliteHMDB00067 (HMDB)
DBIGeneProductENSBTAG00000009517 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155368
FASNGeneProductENSBTAG00000015980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169710
FDFT1GeneProductENSBTAG00000012432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079459
FDPSGeneProductENSBTAG00000003948 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160752
FGF21GeneProductENSBTAG00000011624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105550
GPAMGeneProductENSBTAG00000011917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927
GSK3AGeneProductENSBTAG00000020756 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105723
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamineMetaboliteHMDB00641 (HMDB)
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
HMGCS1GeneProductENSBTAG00000011839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
IDI1GeneProductENSBTAG00000004075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067064
INSIG1GeneProductENSBTAG00000001592 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186480
INSIG2GeneProductENSBTAG00000002112 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125629
InsulinProtein
KPNB1GeneProductENSBTAG00000006586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108424
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
LPIN1GeneProductENSBTAG00000007689 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134324
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175445
LSSGeneProductENSBTAG00000018936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160285
MBTPS1GeneProductENSBTAG00000010170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140943
MBTPS2GeneProductENSBTAG00000008183 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000012174
MDH1GeneProductENSBTAG00000019295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000014641
MED15GeneProductENSBTAG00000018048 (Ensembl)
  • activator recruited cofactor (ARC)-mediator activator complex
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
MVDGeneProductENSBTAG00000012059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167508
NFYAGeneProductENSBTAG00000009905 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001167
NR1H2GeneProductENSBTAG00000003264 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131408
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121879
PPARGC1BGeneProductENSBTAG00000012943 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155846
PPARGGeneProductENSBTAG00000001333 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132170
PRKAA1GeneProductENSBTAG00000000013 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132356
PRKAA2GeneProductENSBTAG00000018747 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162409
PRKAB1GeneProductENSBTAG00000005940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111725
PRKAB2GeneProductENSBTAG00000014387 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131791
PRKACAGeneProductENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072062
PRKAG1GeneProductENSBTAG00000014426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181929
PRKAG2GeneProductENSBTAG00000002917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
PRKAG3GeneProductENSBTAG00000013492 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115592
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
RBP4GeneProductENSBTAG00000000442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138207
RNF139GeneProductENSBTAG00000020399 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170881
SAR1AGeneProductENSBTAG00000016858 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079332
SAR1BGeneProductENSBTAG00000021226 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152700
SCAPGeneProductENSBTAG00000015782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114650
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073060
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099194
SEC13GeneProductENSBTAG00000017825 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157020
SEC23AGeneProductENSBTAG00000003708 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100934
SEC23BGeneProductENSBTAG00000018295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101310
SEC24AGeneProductENSBTAG00000018322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113615
SEC24BGeneProductENSBTAG00000010945 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138802
SEC24CGeneProductENSBTAG00000002791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176986
SEC24DGeneProductENSBTAG00000003619 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150961
SEC31AGeneProductENSBTAG00000020525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138674
SEC31BGeneProductENSBTAG00000000090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075826
SIRT1GeneProductENSBTAG00000014023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591
SQLEGeneProductENSBTAG00000005498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104549
SREBF1GeneProductENSBTAG00000007884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
SREBF2GeneProductENSBTAG00000014265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
UFAsMetaboliteCHEBI:26208 (ChEBI)
YY1GeneProductENSBTAG00000020819 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100811
bta-mir-33aRnaENSBTAG00000029975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Mb:MI0000091
bta-mir-33bRnaENSBTAG00000036437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Mb:MI0003646

Annotated Interactions

No annotated interactions
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