Vitamin B12 Metabolism (Bos taurus)

From WikiPathways

Revision as of 14:13, 14 August 2018 by Egonw (Talk | contribs)
Jump to: navigation, search
565, 124, 126, 155, 187...71, 289112, 126, 210, 246EnzymesNecessary stimulationMicronutrientsSelenoproteinsTranscription factorBiomarker forSelenium statusOther proteinsFrom intracellular part to the plasmaOverarching processCleavageInhibitionBindingis composed ofStimulationProtein with polymorphismReactionNegative EffectLEGENDCofactor conversionMetabolitesProtein*ConversionCatalysisProcess or metabolism involved in Se PathwayCofactorsNitrogen CompundsIntracellularPlasmaa-TocopherolPGF2a8-Isoprostaglandin F2aGIFTCN1Thromboxane A2Thromboxane B2Thromboxane B2TCN2PGE1LRP2DNA Oxidationa-TocopherolNFKB2PGF2aPGE18-Isoprostaglandin F2aRELAProtein tyrosine nitrationLipoprotein metabolismProstaglandin metabolismLipid peroxidationF2-IsoprostaneCUBNCCL2F2-IsoprostaneThromboxane B2PGE2NFKB1CCL2PGE2TCN293, 217264264151, 162, 241, 257, 258, 277219, 249717393, 217714, 102170, 177, 195, 223117, 226264118, 128, 132, 170, 177...32118, 170, 191170, 177, 195132, 219, 249151, 162, 241, 257, 258, 277718, 9714, 10211, 40, 170, 177, 184...7, 14, 19226414, 41, 8311, 40, 170, 177, 184...14, 41, 83MMABCBRMTRMAT1AMUTSHMT2MTRRMM-CoA-HMCEE260, 2831, 85, 195, 248, 254160, 17034, 150194195283, 293286CBS56NADP+NADP+NADHNADP+MPO103, 112, 279CysteineSERPINE1F7SERPINE1PLGF2F2PLATF7PLATPLG77, 14622577, 10777, 14622522522522522577, 107H2O25,10-Methylene-THF34, 1885-methyl-THFCreatinine5-methyl-THFCreatinine1, 71, 100, 188, 202...120, 273120, 2731, 71, 100, 188, 202...SOD3SOD3CTHTHF188NADPHNADNADPHNADPHMTHFR85, 188HomocysteineHomocysteine1, 93, 100, 107, 120...1, 93, 100, 107, 120...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate93, 100, 20293, 100, 202SerineSerine34, 15034, 150SCARB1APOA1VLDLAPOA1oxLDLAPOBVLDL-TAGSERPINA3-7CholesterolABCA1HDLAPOETAGAPOBLDLVLDLCholesterolLDLRTAGHDL/APOA1SAA3APOA1SAA1VLDL/APOBHDLLDLSAA4LDL-CHDL/SAAHDL-CVLDL-TAGoxLDLLDL/APOBHDL-CLDL-CSERPINA3-7SAA225, 116, 17866287185, 204287250, 287128, 249, 28797, 249, 25725, 116, 178666666, 185206, 2876666, 18528797, 249, 25728766, 22128797, 249, 257206, 28725066, 221128, 2877028797, 249, 257206, 287204, 261261, 29925, 178206, 287287261, 299206, 250, 28766Vitamin B12/Cobalamin8-OHdGFADMethylcob(III)alaminAdenosylcobalaminCob(I)alaminMethylcob(III)alaminVitamin B12/CobalaminCob(II)alamin8-OHdGAdenosylcobalamin100, 116, 167, 170, 177...195, 28332160, 19571, 195, 283, 28971, 195, 283, 28932160, 19581, 94, 100, 116, 167...98, 195, 283vitamin Dvitamin DChlorineChlorine116116CystathionineSOD2ZincZincHNO2HOClNONO3-NO2N2OO3103, 142, 248, 279248, 254HBAIFNGFibrinogenINSIFNGTNFFibrinIL1BTNFALBIL1BFibrinogenINSRD-dimerFibrinIL6D-dimerCCL5ICAM1HbA1cALBHbA1cINSHBGIL6CCL5CRP124, 132110, 12694, 110, 126, 24372, 81, 163146, 22518783, 126, 266118, 271146, 22569, 100, 11072, 8443, 22518769, 100, 110124, 132164126, 26622016472, 81, 163100, 117, 139, 220, 243...43, 225118, 27116416472, 126, 22072, 83, 126, 220, 222RiboflavinRiboflavin116, 158116, 158O2 Methylmalonic acidCbl/IF S-AdenosylhomocysteineL-Methylmalonyl-CoACbl/TC Succinyl-CoA S-Adenosylhomocysteine Methylmalonic acid S-AdenosylmethionineMethionineCbl/TCD-Methylmalonyl-CoAMethionine S-AdenosylmethionineCbl/HC170, 177, 1951, 188, 196188, 194, 237, 283188, 194, 237, 283179, 188170, 177, 195160, 167160, 170179, 188160, 170160170, 177, 195170, 177, 195, 2731, 188, 196160, 170NitrotyrosineONOO-ONOOH173FructosamineFructosamineGlucoseGlucose271163, 164271163, 164Ascorbic acidAscorbic acidAscorbic acid89, 151, 25889, 151, 25889, 151, 258


Description

Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain.

Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons.

Animals store vitamin B12 in liver and muscle and therefore eggs, milk, meat, liver are sources of the vitamin.

Problems in metabolism of vitamin B12 lead to "persistent" lack of energy to perform every day tasks.

The genes and pathways highlighted above describe several routes through which genes and metabolites involved in B12 metabolism are interconnected.

Central B12 metabolism nodes include folate metabolism and the synthesis of the citric acid cycle intermediates and succinyl-CoA, cyanocobalamin into methylcobalamin conversion, tyrosine nitration and riboflavin pathways.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP1533_96310 with a 81.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Yang P, Chan D, Felix E, Cartwright C, Menter DG, Madden T, Klein RD, Fischer SM, Newman RA; ''Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.''; J Lipid Res, 2004 PubMed Europe PMC
  2. Lykidis A, Jackson PD, Rock CO, Jackowski S; ''The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.''; J Biol Chem, 1997 PubMed Europe PMC
  3. Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S; ''Enzymology of NAD+ homeostasis in man.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  4. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  5. Eberhardt C, Gray PW, Tjoelker LW; ''Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.''; J Biol Chem, 1997 PubMed Europe PMC
  6. Helgerud P, Saarem K, Norum KR; ''Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.''; J Lipid Res, 1981 PubMed Europe PMC
  7. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC
  8. Son YH, Jeong YT, Lee KA, Choi KH, Kim SM, Rhim BY, Kim K; ''Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.''; J Cardiovasc Pharmacol, 2008 PubMed Europe PMC
  9. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.''; Diabetes Care, 2007 PubMed Europe PMC
  10. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC
  11. Sica A, Tan TH, Rice N, Kretzschmar M, Ghosh P, Young HA; ''The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.''; Proc Natl Acad Sci U S A, 1992 PubMed Europe PMC
  12. Ho AW, Wong CK, Lam CW; ''Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.''; Immunobiology, 2008 PubMed Europe PMC
  13. Marnett LJ; ''Lipid peroxidation-DNA damage by malondialdehyde.''; Mutat Res, 1999 PubMed Europe PMC
  14. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC
  15. Steinbrenner H, Sies H; ''Protection against reactive oxygen species by selenoproteins.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  16. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC
  17. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W; ''Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study.''; Eur J Clin Nutr, 2008 PubMed Europe PMC
  18. Fowler B, Leonard JV, Baumgartner MR; ''Causes of and diagnostic approach to methylmalonic acidurias.''; J Inherit Metab Dis, 2008 PubMed Europe PMC
  19. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC; ''Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression.''; Science, 1989 PubMed Europe PMC
  20. Bertran N, Camps J, Fernandez-Ballart J, Arija V, Ferre N, Tous M, Simo D, Murphy MM, Vilella E, Joven J; ''Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study.''; J Lab Clin Med, 2005 PubMed Europe PMC
  21. Reilly IA, FitzGerald GA; ''Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.''; Blood, 1987 PubMed Europe PMC
  22. Bjørke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, Refsum H; ''Determinants of cobalamin status in newborns.''; Pediatrics, 2001 PubMed Europe PMC
  23. Panee J, Stoytcheva ZR, Liu W, Berry MJ; ''Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.''; J Biol Chem, 2007 PubMed Europe PMC
  24. Bailey JM, Bryant RW, Whiting J, Salata K; ''Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.''; J Lipid Res, 1983 PubMed Europe PMC
  25. Amaral JD, Castro RE, Steer CJ, Rodrigues CM; ''p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.''; Trends Mol Med, 2009 PubMed Europe PMC
  26. Taki T, Kanfer JN; ''Phospholipase D from rat brain.''; Methods Enzymol, 1981 PubMed Europe PMC
  27. Choi SW, Mason JB; ''Folate and carcinogenesis: an integrated scheme.''; J Nutr, 2000 PubMed Europe PMC
  28. Ahlberg J, Angelin B, Björkhem I, Einarsson K, Leijd B; ''Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.''; J Lipid Res, 1979 PubMed Europe PMC
  29. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.''; J Exp Med, 2005 PubMed Europe PMC
  30. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett, 2006 PubMed Europe PMC
  31. Johnson MR, Barnes S, Diasio RB; ''Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.''; Anal Biochem, 1989 PubMed Europe PMC
  32. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW; ''cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.''; J Biol Chem, 1998 PubMed Europe PMC
  33. Burk RF, Hill KE, Motley AK; ''Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.''; J Nutr, 2003 PubMed Europe PMC
  34. Kim YI; ''Role of the MTHFR polymorphisms in cancer risk modification and treatment.''; Future Oncol, 2009 PubMed Europe PMC
  35. Kovacs E; ''The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy.''; Biomed Pharmacother, 2005 PubMed Europe PMC
  36. Walker GA, Murphy S, Huennekens FM; ''Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems.''; Arch Biochem Biophys, 1969 PubMed Europe PMC
  37. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC
  38. Refsum H, Johnston C, Guttormsen AB, Nexo E; ''Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults.''; Clin Chem, 2006 PubMed Europe PMC
  39. Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M; ''Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.''; Clin Exp Allergy, 2006 PubMed Europe PMC
  40. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, Radermacher P, Calzia E; ''Glucose metabolism and catecholamines.''; Crit Care Med, 2007 PubMed Europe PMC
  41. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ; ''Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.''; Am J Hum Genet, 2001 PubMed Europe PMC
  42. Cheng JB, Jacquemin E, Gerhardt M, Nazer H, Cresteil D, Heubi JE, Setchell KD, Russell DW; ''Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC
  43. Cali JJ, Russell DW; ''Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.''; J Biol Chem, 1991 PubMed Europe PMC
  44. MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV; ''Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.''; Appl Environ Microbiol, 1982 PubMed Europe PMC
  45. Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL; ''Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.''; Neurochem Int, 1999 PubMed Europe PMC
  46. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC
  47. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, Jenkins NA, Ferrick DA, Kastelein RA, Bazan JF, Zlotnik A; ''Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  48. Scalabrino G, Peracchi M; ''New insights into the pathophysiology of cobalamin deficiency.''; Trends Mol Med, 2006 PubMed Europe PMC
  49. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J; ''NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.''; J Biol Chem, 2006 PubMed Europe PMC
  50. el Attar TM, Lin HS; ''Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells.''; Prostaglandins Leukot Essent Fatty Acids, 1992 PubMed Europe PMC
  51. Abu Khaled M, Watkins CL, Krumdieck CL; ''Inactivation of B12 and folate coenzymes by butyl nitrite as observed by NMR: implications on one-carbon transfer mechanism.''; Biochem Biophys Res Commun, 1986 PubMed Europe PMC
  52. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC
  53. Rampersaud GC, Kauwell GP, Bailey LB; ''Folate: a key to optimizing health and reducing disease risk in the elderly.''; J Am Coll Nutr, 2003 PubMed Europe PMC
  54. Yun J, Kim JY, Kim OY, Jang Y, Chae JS, Kwak JH, Lim HH, Park HY, Lee SH, Lee JH; ''Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.''; Nutr Metab Cardiovasc Dis, 2009 PubMed Europe PMC
  55. Liu YY, Han TY, Giuliano AE, Cabot MC; ''Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.''; J Biol Chem, 1999 PubMed Europe PMC
  56. Gaughan DJ, Kluijtmans LA, Barbaux S, McMaster D, Young IS, Yarnell JW, Evans A, Whitehead AS; ''The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations.''; Atherosclerosis, 2001 PubMed Europe PMC
  57. Miyazaki M, Kanto T, Inoue M, Itose I, Miyatake H, Sakakibara M, Yakushijin T, Kakita N, Hiramatsu N, Takehara T, Kasahara A, Hayashi N; ''Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.''; J Med Virol, 2008 PubMed Europe PMC
  58. Chanarin I; ''Cobalamins and nitrous oxide: a review.''; J Clin Pathol, 1980 PubMed Europe PMC
  59. Mahley RW; ''Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.''; Science, 1988 PubMed Europe PMC
  60. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.''; Biochim Biophys Acta, 2006 PubMed Europe PMC
  61. Fakhrzadeh H, Ghotbi S, Pourebrahim R, Nouri M, Heshmat R, Bandarian F, Shafaee A, Larijani B; ''Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study.''; BMC Public Health, 2006 PubMed Europe PMC
  62. Feghali CA, Wright TM; ''Cytokines in acute and chronic inflammation.''; Front Biosci, 1997 PubMed Europe PMC
  63. Olivier LM, Chambliss KL, Gibson KM, Krisans SK; ''Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.''; J Lipid Res, 1999 PubMed Europe PMC
  64. Northrop-Clewes CA, Thurnham DI; ''Monitoring micronutrients in cigarette smokers.''; Clin Chim Acta, 2007 PubMed Europe PMC
  65. Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR; ''Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).''; J Lipid Res, 2006 PubMed Europe PMC
  66. Nakamura MT, Nara TY; ''Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases.''; Annu Rev Nutr, 2004 PubMed Europe PMC
  67. Smith WL; ''Cyclooxygenases, peroxide tone and the allure of fish oil.''; Curr Opin Cell Biol, 2005 PubMed Europe PMC
  68. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ; ''Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.''; J Biol Chem, 1997 PubMed Europe PMC
  69. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr; ''Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.''; Biol Trace Elem Res, 2008 PubMed Europe PMC
  70. Murakami M, Nakatani Y, Tanioka T, Kudo I; ''Prostaglandin E synthase.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  71. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B; ''Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.''; J Am Coll Nutr, 1998 PubMed Europe PMC
  72. Horrobin DF; ''Fatty acid metabolism in health and disease: the role of delta-6-desaturase.''; Am J Clin Nutr, 1993 PubMed Europe PMC
  73. Shen W, Stone K, Jales A, Leitenberg D, Ladisch S; ''Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides.''; J Immunol, 2008 PubMed Europe PMC
  74. Hahn FM, Xuan JW, Chambers AF, Poulter CD; ''Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.''; Arch Biochem Biophys, 1996 PubMed Europe PMC
  75. Holleran WM, Williams ML, Gao WN, Elias PM; ''Serine-palmitoyl transferase activity in cultured human keratinocytes.''; J Lipid Res, 1990 PubMed Europe PMC
  76. Cao S, Zhang X, Edwards JP, Mosser DM; ''NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.''; J Biol Chem, 2006 PubMed Europe PMC
  77. Puig-Kröger A, Sierra-Filardi E, Domí­nguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, Ratnam M, Sánchez-Mateos P, Corbí­ AL; ''Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.''; Cancer Res, 2009 PubMed Europe PMC
  78. Bierbach H; ''Studies on long chain fatty acid:CoA ligase from human small intestine.''; Gut, 1980 PubMed Europe PMC
  79. Skacel N, Menon LG, Mishra PJ, Peters R, Banerjee D, Bertino JR, Abali EE; ''Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.''; J Biol Chem, 2005 PubMed Europe PMC
  80. Krishnaveni GV, Hill JC, Veena SR, Bhat DS, Wills AK, Karat CL, Yajnik CS, Fall CH; ''Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.''; Diabetologia, 2009 PubMed Europe PMC
  81. Momoi T, Ben-Yoseph Y, Nadler HL; ''Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls.''; Biochem J, 1982 PubMed Europe PMC
  82. Köhrle J, Jakob F, Contempré B, Dumont JE; ''Selenium, the thyroid, and the endocrine system.''; Endocr Rev, 2005 PubMed Europe PMC
  83. Packer L, Witt EH, Tritschler HJ; ''alpha-Lipoic acid as a biological antioxidant.''; Free Radic Biol Med, 1995 PubMed Europe PMC
  84. Struys EA, Jansen EE, de Meer K, Jakobs C; ''Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry.''; Clin Chem, 2000 PubMed Europe PMC
  85. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, Bishara N, Quick M, Kantham L, Collier GR; ''Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein.''; FEBS Lett, 2004 PubMed Europe PMC
  86. Das UN; ''Folic acid says NO to vascular diseases.''; Nutrition, 2003 PubMed Europe PMC
  87. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.''; Blood, 2006 PubMed Europe PMC
  88. Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M; ''Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5.''; Proc Natl Acad Sci U S A, 1986 PubMed Europe PMC
  89. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC
  90. Abate A, Yang G, Dennery PA, Oberle S, Schröder H; ''Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.''; Free Radic Biol Med, 2000 PubMed Europe PMC
  91. Johnsen IB, Nguyen TT, Ringdal M, Tryggestad AM, Bakke O, Lien E, Espevik T, Anthonsen MW; ''Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.''; EMBO J, 2006 PubMed Europe PMC
  92. Sniderman AD; ''How, when, and why to use apolipoprotein B in clinical practice.''; Am J Cardiol, 2002 PubMed Europe PMC
  93. Franken PA, Van den Berg L, Huang J, Gunyuzlu P, Lugtigheid RB, Verheij HM, De Haas GH; ''Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.''; Eur J Biochem, 1992 PubMed Europe PMC
  94. Hussein O, Rosenblat M, Refael G, Aviram M; ''Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients.''; Transplantation, 1997 PubMed Europe PMC
  95. Yamashita S, Hosaka K, Numa S; ''Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes.''; Eur J Biochem, 1973 PubMed Europe PMC
  96. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  97. Huerta C, Borek D, Machius M, Grishin NV, Zhang H; ''Structure and mechanism of a eukaryotic FMN adenylyltransferase.''; J Mol Biol, 2009 PubMed Europe PMC
  98. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.''; J Trace Elem Med Biol, 2002 PubMed Europe PMC
  99. Wang LH, Kulmacz RJ; ''Thromboxane synthase: structure and function of protein and gene.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  100. Bills TK, Smith JB, Silver MJ; ''Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.''; J Clin Invest, 1977 PubMed Europe PMC
  101. Navab M, Anantharamaiah GM, Reddy ST, Van Lenten BJ, Fogelman AM; ''HDL as a biomarker, potential therapeutic target, and therapy.''; Diabetes, 2009 PubMed Europe PMC
  102. Politis A, Olgiati P, Malitas P, Albani D, Signorini A, Polito L, De Mauro S, Zisaki A, Piperi C, Stamouli E, Mailis A, Batelli S, Forloni G, De Ronchi D, Kalofoutis A, Liappas I, Serretti A; ''Vitamin B12 levels in Alzheimer's disease: association with clinical features and cytokine production.''; J Alzheimers Dis, 2010 PubMed Europe PMC
  103. Brigelius-Flohé R; ''Tissue-specific functions of individual glutathione peroxidases.''; Free Radic Biol Med, 1999 PubMed Europe PMC
  104. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.''; J Biol Chem, 2007 PubMed Europe PMC
  105. Peters-Golden M, Brock TG; ''5-lipoxygenase and FLAP.''; Prostaglandins Leukot Essent Fatty Acids, 2003 PubMed Europe PMC
  106. Okuma M, Yamashita S, Numa S; ''Enzymic studies on phosphatidic acid synthesis in human platelets.''; Blood, 1973 PubMed Europe PMC
  107. Simmons DL, Botting RM, Hla T; ''Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.''; Pharmacol Rev, 2004 PubMed Europe PMC
  108. Hesse-Bähr K, Dreher I, Köhrle J; ''The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2.''; Biofactors, 2000 PubMed Europe PMC
  109. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.''; Am J Hum Genet, 1998 PubMed Europe PMC
  110. Semnani RT, Venugopal PG, Leifer CA, Mostböck S, Sabzevari H, Nutman TB; ''Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.''; Blood, 2008 PubMed Europe PMC
  111. Birn H, Willnow TE, Nielsen R, Norden AG, Bönsch C, Moestrup SK, Nexø E, Christensen EI; ''Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).''; Am J Physiol Renal Physiol, 2002 PubMed Europe PMC
  112. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; J Biol Chem, 1992 PubMed Europe PMC
  113. Singh S, Madzelan P, Banerjee R; ''Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.''; Nat Prod Rep, 2007 PubMed Europe PMC
  114. Zamocky M, Furtmüller PG, Obinger C; ''Evolution of catalases from bacteria to humans.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  115. Ferré P; ''The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.''; Diabetes, 2004 PubMed Europe PMC
  116. Klebanoff SJ; ''Myeloperoxidase: friend and foe.''; J Leukoc Biol, 2005 PubMed Europe PMC
  117. Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW; ''The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.''; J Clin Invest, 2000 PubMed Europe PMC
  118. Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S; ''Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.''; J Biol Chem, 2001 PubMed Europe PMC
  119. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.''; Biochem Pharmacol, 2008 PubMed Europe PMC
  120. Shimojo T, Akino T, Miura Y, Schroepfer GJ Jr; ''Sphingolipid base metabolism. Stereospecific uptake of proton in the enzymatic conversion of sphinganine 1-phosphate to ethanolamine 1-phosphate.''; J Biol Chem, 1976 PubMed Europe PMC
  121. Edmondson DE, Newton-Vinson P; ''The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.''; Antioxid Redox Signal, 2001 PubMed Europe PMC
  122. Moore SA, Hurt E, Yoder E, Sprecher H, Spector AA; ''Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.''; J Lipid Res, 1995 PubMed Europe PMC
  123. Salem N Jr, Pawlosky R, Wegher B, Hibbeln J; ''In vivo conversion of linoleic acid to arachidonic acid in human adults.''; Prostaglandins Leukot Essent Fatty Acids, 1999 PubMed Europe PMC
  124. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J; ''Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  125. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.''; Biochem J, 2002 PubMed Europe PMC
  126. Schäfer M, Werner S; ''Oxidative stress in normal and impaired wound repair.''; Pharmacol Res, 2008 PubMed Europe PMC
  127. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y; ''A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.''; J Biol Chem, 1997 PubMed Europe PMC
  128. Kovachy RJ, Copley SD, Allen RH; ''Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase.''; J Biol Chem, 1983 PubMed Europe PMC
  129. Jakobsson A, Westerberg R, Jacobsson A; ''Fatty acid elongases in mammals: their regulation and roles in metabolism.''; Prog Lipid Res, 2006 PubMed Europe PMC
  130. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT; ''Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes.''; J Lipid Res, 1987 PubMed Europe PMC
  131. Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA; ''Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.''; Eur J Biochem, 1993 PubMed Europe PMC
  132. Chatterjee S, Castiglione E; ''UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.''; Biochim Biophys Acta, 1987 PubMed Europe PMC
  133. Verkleij-Hagoort AC, van Driel LM, Lindemans J, Isaacs A, Steegers EA, Helbing WA, Uitterlinden AG, Steegers-Theunissen RP; ''Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study.''; Mol Genet Metab, 2008 PubMed Europe PMC
  134. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F; ''Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.''; Eur J Immunol, 2005 PubMed Europe PMC
  135. Ogawa H, Gomi T, Fujioka M; ''Serine hydroxymethyltransferase and threonine aldolase: are they identical?''; Int J Biochem Cell Biol, 2000 PubMed Europe PMC
  136. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.''; Biochim Biophys Acta, 1998 PubMed Europe PMC
  137. Giera M, Renard D, Plössl F, Bracher F; ''Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.''; Steroids, 2008 PubMed Europe PMC
  138. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA; ''A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.''; Nature, 2004 PubMed Europe PMC
  139. Swanson DA, Pangilinan F, Mills JL, Kirke PN, Conley M, Weiler A, Frey T, Parle-McDermott A, O'Leary VB, Seltzer RR, Moynihan KA, Molloy AM, Burke H, Scott JM, Brody LC; ''Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.''; Birth Defects Res A Clin Mol Teratol, 2005 PubMed Europe PMC
  140. Correa-Cerro LS, Porter FD; ''3beta-hydroxysterol Delta7-reductase and the Smith-Lemli-Opitz syndrome.''; Mol Genet Metab, 2005 PubMed Europe PMC
  141. Bailey SW, Ayling JE; ''The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC
  142. Whitaker MO, Wyche A, Fitzpatrick F, Sprecher H, Needleman P; ''Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  143. Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A; ''Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.''; Ann Neurol, 2009 PubMed Europe PMC
  144. Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM; ''Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.''; J Biol Chem, 2003 PubMed Europe PMC
  145. Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld EJ, Notarangelo LD; ''Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.''; Clin Immunol, 2009 PubMed Europe PMC
  146. Engels F, Nijkamp FP; ''Pharmacological inhibition of leukotriene actions.''; Pharm World Sci, 1998 PubMed Europe PMC
  147. Watanabe F, Oki Y, Nakano Y, Kitaoka S; ''Occurrence and characterization of cyanocobalamin reductase (NADPH; CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis.''; J Nutr Sci Vitaminol (Tokyo), 1988 PubMed Europe PMC
  148. Pesch J, Brehm U, Staib C, Grummt F; ''Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53.''; J Interferon Cytokine Res, 1996 PubMed Europe PMC
  149. Eklund CM; ''Proinflammatory cytokines in CRP baseline regulation.''; Adv Clin Chem, 2009 PubMed Europe PMC
  150. Wu C, Bates SM; ''Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism?''; Pol Arch Med Wewn, 2009 PubMed Europe PMC
  151. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.''; Science, 2003 PubMed Europe PMC
  152. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  153. Wickremasinghe MI, Thomas LH, O'Kane CM, Uddin J, Friedland JS; ''Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis.''; J Biol Chem, 2004 PubMed Europe PMC
  154. Huijghebaert SM, Hofmann AF; ''Influence of the amino acid moiety on deconjugation of bile acid amidates by cholylglycine hydrolase or human fecal cultures.''; J Lipid Res, 1986 PubMed Europe PMC
  155. White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB; ''Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708.''; J Lipid Res, 1981 PubMed Europe PMC
  156. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T; ''Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.''; Arterioscler Thromb Vasc Biol, 2002 PubMed Europe PMC
  157. Abu-Soud HM, Hazen SL; ''Nitric oxide is a physiological substrate for mammalian peroxidases.''; J Biol Chem, 2000 PubMed Europe PMC
  158. Chen D, Zhang XY, Shi Y; ''Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.''; Biochem J, 2006 PubMed Europe PMC
  159. Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M; ''Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c -->t methylenetetrahydrofolate reductase and 2756a -->g methionine synthase genotypes.''; Mol Genet Metab, 2000 PubMed Europe PMC
  160. Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M; ''Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  161. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC
  162. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN; ''Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.''; Biochem Soc Trans, 2007 PubMed Europe PMC
  163. Cipollone F, Cicolini G, Bucci M; ''Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.''; Pharmacol Ther, 2008 PubMed Europe PMC
  164. Kypreos KE, van Dijk KW, van Der Zee A, Havekes LM, Zannis VI; ''Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.''; J Biol Chem, 2001 PubMed Europe PMC
  165. Bianco AC, Kim BW; ''Deiodinases: implications of the local control of thyroid hormone action.''; J Clin Invest, 2006 PubMed Europe PMC
  166. Shigenaga MK, Gimeno CJ, Ames BN; ''Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC
  167. Erickson SK, Bösterling B; ''Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.''; J Lipid Res, 1981 PubMed Europe PMC
  168. Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR; ''Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.''; Cytokine, 2006 PubMed Europe PMC
  169. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.''; J Biol Chem, 1998 PubMed Europe PMC
  170. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN; ''Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.''; Am J Physiol, 1998 PubMed Europe PMC
  171. Häberle J, Pauli S, Berning C, Koch HG, Linnebank M; ''TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations.''; J Hum Genet, 2009 PubMed Europe PMC
  172. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol., 2002 PubMed Europe PMC
  173. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T; ''Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.''; J Biol Chem, 2004 PubMed Europe PMC
  174. Schumm K, Rocha S, Caamano J, Perkins ND; ''Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.''; EMBO J, 2006 PubMed Europe PMC
  175. Nitahara Y, Aoyama Y, Horiuchi T, Noshiro M, Yoshida Y; ''Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.''; J Biochem, 1999 PubMed Europe PMC
  176. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC
  177. Anderson ME, Allison RD, Meister A; ''Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.''; Proc Natl Acad Sci U S A, 1982 PubMed Europe PMC
  178. Jakubowski H; ''Molecular basis of homocysteine toxicity in humans.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  179. Bakovic M, Fullerton MD, Michel V; ''Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2).''; Biochem Cell Biol, 2007 PubMed Europe PMC<