Vitamin B12 Metabolism (Bos taurus)

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565, 124, 126, 155, 187...71, 289112, 126, 210, 246MicronutrientsStimulationFrom intracellular part to the plasmaCofactor conversionBindingConversionMetabolitesTranscription factorOther proteinsSelenoproteinsLEGENDNegative Effectis composed ofProcess or metabolism involved in Se PathwayProtein*ReactionProtein with polymorphismBiomarker forSelenium statusCatalysisInhibitionEnzymesCleavageNecessary stimulationCofactorsOverarching processNitrogen CompundsIntracellularPlasmaCCL2GIFTCN28-Isoprostaglandin F2aProtein tyrosine nitrationPGE2F2-IsoprostaneDNA OxidationPGE1Thromboxane B2CCL2TCN2PGE1Thromboxane B2a-TocopherolLipid peroxidationPGF2aCUBNPGF2aRELA8-Isoprostaglandin F2aLipoprotein metabolismProstaglandin metabolismTCN1Thromboxane A2a-TocopherolThromboxane B2NFKB2NFKB1LRP2F2-IsoprostanePGE27, 14, 192726432170, 177, 195, 22393, 21714, 102117, 226264219, 24926477173118, 170, 19114, 102151, 162, 241, 257, 258, 27711, 40, 170, 177, 184...18, 9726414, 41, 8311, 40, 170, 177, 184...118, 128, 132, 170, 177...151, 162, 241, 257, 258, 277170, 177, 19593, 21714, 41, 83132, 219, 249MTRRMM-CoA-HMAT1ACBRMTRMUTMMABSHMT2MCEE286260, 283160, 1701, 85, 195, 248, 254194195283, 29334, 150CBS56NADHNADP+NADP+NADP+MPO103, 112, 279CysteineF2F2PLGSERPINE1F7PLGPLATPLATSERPINE1F777, 10722522522522522577, 14677, 14677, 107225H2O25,10-Methylene-THF34, 1885-methyl-THFCreatinineCreatinine5-methyl-THF120, 2731, 71, 100, 188, 202...1, 71, 100, 188, 202...120, 273SOD3SOD3CTHTHF188NADPHNADNADPHNADPHMTHFR85, 188HomocysteineHomocysteine1, 93, 100, 107, 120...1, 93, 100, 107, 120...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate93, 100, 20293, 100, 202SerineSerine34, 15034, 150VLDLLDLSERPINA3-7APOA1HDLTAGVLDLLDL-CSAA1TAGVLDL/APOBSAA3APOBAPOA1LDLVLDL-TAGoxLDLSCARB1HDLoxLDLLDL-CHDL-CHDL-CLDLRAPOBABCA1SAA4CholesterolHDL/SAAVLDL-TAGAPOESAA2HDL/APOA1CholesterolSERPINA3-7APOA1LDL/APOB28728770204, 261261, 29966, 221261, 29997, 249, 25728728728725, 17897, 249, 257206, 28766, 18566206, 250, 287128, 249, 28725, 116, 17866, 221250, 28797, 249, 2576628766206, 28766250287206, 28797, 249, 257206, 287128, 28766, 18525, 116, 17866185, 204Vitamin B12/CobalaminCob(I)alaminCob(II)alaminMethylcob(III)alaminVitamin B12/CobalaminAdenosylcobalamin8-OHdGAdenosylcobalaminFAD8-OHdGMethylcob(III)alamin81, 94, 100, 116, 167...71, 195, 283, 28932100, 116, 167, 170, 177...160, 19598, 195, 283195, 283160, 19571, 195, 283, 28932Chlorinevitamin DChlorinevitamin D116116CystathionineSOD2ZincZincO3NONO3-N2ONO2HOClHNO2103, 142, 248, 279248, 254IFNGHbA1cTNFINSRD-dimerHBGCRPFibrinogenD-dimerIL1BIL6FibrinTNFALBALBFibrinIL1BHbA1cIL6CCL5FibrinogenINSCCL5INSICAM1HBAIFNG18769, 100, 11022072, 81, 16394, 110, 126, 24383, 126, 266126, 26672, 84164118, 27118772, 81, 163124, 132110, 12616443, 22572, 126, 22043, 225124, 132164146, 22516469, 100, 110118, 27172, 83, 126, 220, 222146, 225100, 117, 139, 220, 243...RiboflavinRiboflavin116, 158116, 158O2MethionineCbl/TCL-Methylmalonyl-CoA S-AdenosylmethionineCbl/HCMethionine Methylmalonic acid S-AdenosylmethionineD-Methylmalonyl-CoACbl/IF Methylmalonic acidCbl/TC S-Adenosylhomocysteine S-Adenosylhomocysteine Succinyl-CoA160, 170160, 170188, 194, 237, 283170, 177, 195160170, 177, 195, 273170, 177, 195179, 1881, 188, 196170, 177, 195179, 188188, 194, 237, 283160, 1671, 188, 196160, 170ONOO-ONOOHNitrotyrosine173GlucoseFructosamineFructosamineGlucose271271163, 164163, 164Ascorbic acidAscorbic acidAscorbic acid89, 151, 25889, 151, 25889, 151, 258


Description

Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain.

Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons.

Animals store vitamin B12 in liver and muscle and therefore eggs, milk, meat, liver are sources of the vitamin.

Problems in metabolism of vitamin B12 lead to "persistent" lack of energy to perform every day tasks.

The genes and pathways highlighted above describe several routes through which genes and metabolites involved in B12 metabolism are interconnected.

Central B12 metabolism nodes include folate metabolism and the synthesis of the citric acid cycle intermediates and succinyl-CoA, cyanocobalamin into methylcobalamin conversion, tyrosine nitration and riboflavin pathways.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP1533_96310 with a 81.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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