TSLP Signaling Pathway (Bos taurus)

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MAP2K2S226MAPK3T207T202Y204DissociationSurvival and chemotaxis ofeosinophilsTSLPCRLF2STAT1STAT3Y701Y705S727STAT4Y693MAPK1T185Y187PTPN11JAK2Y542JAK1Y1007Y570Y1008Y1035IL7RY1034MAP2K1S218S222MAPK14T180Y182BIKBARELBPRELANFKB1NFKB2MAPK8Y185T183RELARELBNFKB1NFKB2TECY519PI3KRPS6S236S236EIF4EBP1T70MTORC1AKT1S473T308GAB2PSTAT6Y641Thymic stromal lymphopoietin Signaling PathwaySRCY419STAT5BY699STAT5AY694CCL11Dentritic cell-mediatedTh2 responseProliferation ofpre-ALL cellsCell proliferationAnti-apoptosisDentritic cell migrationInvasion of trophoblastsAirway inflammatory responseSTAT5BY699STAT5AY694STAT3Y705S727MAPK9T183Y185MYCCXCL8IL2RAIL6CISHTNFSF4NUCYNUCYNUCYNUCYNUCYNUCYNUCYYES1LCKY426Y394BTKY551FESY713HCKY411FYNT412Y420LYNY397Cell proliferationAirway inflammatory response


Description

Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia. Description source: NetPath

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2203(78549) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

CompareRevisionActionTimeUserComment
96066view17:59, 15 February 2018KhanspersModified description
85045view09:38, 10 April 2016EgonwReplaced a mim-conversion with mim-stimulation.
80774view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
BIKBAProteinENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792
BTKProteinENSBTAG00000019250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:695
CCL11RnaENSBTAG00000004129 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6356
CISHRnaENSBTAG00000022622 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154
CRLF2ProteinENSBTAG00000020242 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64109
CXCL8RnaENSBTAG00000019716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3576
EIF4EBP1ProteinENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
FESProteinENSBTAG00000002941 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2242
FYNProteinENSBTAG00000011851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GAB2Protein
HCKProteinENSBTAG00000007932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3055
IL2RARnaENSBTAG00000020892 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3559
IL6RnaENSBTAG00000014921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
IL7RProteinENSBTAG00000019975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3575
JAK1ProteinENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2ProteinENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
LCKProteinENSBTAG00000012695 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932
LYNProteinENSBTAG00000020034 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4067
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3ProteinENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK8ProteinENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9ProteinENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MTORC1Complex2475 (Entrez Gene)
MTORProteinENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
MYCRnaENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NFKB1ProteinENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2ProteinENSBTAG00000006017 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4791
PI3KComplex2.7.1.153 (Enzyme Nomenclature)
PI4K2AProteinENSBTAG00000002010 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55361
PIK3CAProteinENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PTPN11ProteinENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
RELAProteinENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RELBProteinENSBTAG00000038428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5971
RPS6ProteinENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT4ProteinENSBTAG00000046699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775
STAT5AProteinENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BProteinENSBTAG00000010125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
STAT6ProteinENSBTAG00000006335 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6778
TECProteinENSBTAG00000005062 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7006
TNFSF4RnaENSBTAG00000002894 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7292
TSLPProtein
YES1ProteinENSBTAG00000001523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7525

Annotated Interactions

No annotated interactions
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