NRF2 pathway (Bos taurus)

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12DegradationTransportPhase 2 proteinsTranscriptionOtherGrowth factor and receptorsPhase 1 proteinsAntioxidant proteinsTranscription Factors4747474747474747LigandSLC2A1CES3ME1PRDX1GSTA2SLC2A11GPX221HGFUGT1A4FGF1322BLVRBGCLCMGST3SLC7A11NFE2L2GSTA2SLC2A13ABCC2TXNABCC4ECSODSLC2A9GPX3ADH7EPHA3GSRHSP90AB1GSTT1SLC2A7SLC2A3SRXN1UGT1A722PGDCBR1ALDH3A1CYP2A6PPARDCBR3TGFB1G6PDUGT1A6TXNRD122TGFB2ABCC3UGT1A9GSTP122CES5APTGR1GSTA2UGT1A122PRDX6HSP90AA1GGT1GSTA4NQO19DNAJB1CES1CES4ATGFAGSTT1UGT2B722SLC2A10SLC2A12GSTA2GCLMABCC5MAFFGGFBPP5SLC2A5MGST2SERPINA1SQSTM1EGR1CES2SLC2A4SLC2A2UGT1A3SLC2A622SLC2A8FTLEPHA2HMOX1MAFGHBEGFHSPA1AKEAP1FTH1TGFBR2SLC2A3PDGFBAGERTXNRD3CYP4A11GenesTATA boxRXRALigandARENRF2 targetgenesGSTM5GSTM1GSTM2GSTM3GSTM1SLC5A2SGLT1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SMCT1SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14NFE2L2KEAP1NFE2L2LigandNFE2L2


Description

NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2884(79992) with a 89.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

View all...
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  48. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed
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  52. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed

History

CompareRevisionActionTimeUserComment
87958view13:11, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
80773view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProduct
ABCC3GeneProduct
ABCC4GeneProductENSBTAG00000046611 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125257
ABCC5GeneProductENSBTAG00000017666 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114770
ADH7GeneProductENSBTAG00000015729 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196344
AGERGeneProductENSBTAG00000014420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204305
ALDH3A1GeneProductENSBTAG00000021113 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108602
BLVRBGeneProductENSBTAG00000010508 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090013
CBR1GeneProduct
CBR3GeneProductENSBTAG00000018688 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159231
CES1GeneProductENSBTAG00000011021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198848
CES2GeneProductENSBTAG00000005093 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172831
CES3GeneProductENSBTAG00000040413 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172828
CES4AGeneProductENSBTAG00000038325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172824
CES5AGeneProductENSBTAG00000011164 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159398
CYP2A6GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
CYP4A11GeneProductENSBTAG00000000229 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048
DNAJB1GeneProductENSBTAG00000045858 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132002
ECSODGeneProductENSBTAG00000013980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109610
EGR1GeneProductENSBTAG00000010069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120738
EPHA2GeneProductENSBTAG00000000815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142627
EPHA3GeneProductENSBTAG00000006811 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000044524
FGF13GeneProductENSBTAG00000020194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129682
FTH1GeneProduct
FTLGeneProductENSBTAG00000019709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087086
G6PDGeneProductENSBTAG00000019512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160211
GCLCGeneProductENSBTAG00000015571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001084
GCLMGeneProductENSBTAG00000007842 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023909
GGFBPP5GeneProductENSBTAG00000004150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157168
GGT1GeneProductENSBTAG00000046900 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100031
GPX2GeneProductENSBTAG00000048112 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176153
GPX3GeneProductENSBTAG00000043553 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000211445
GSRGeneProductENSBTAG00000007115 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104687
GSTA2GeneProductENSBTAG00000006546 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000244067
GSTA4GeneProductENSBTAG00000004288 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170899
GSTM1GeneProduct
GSTM1GeneProductENSBTAG00000031788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168765
GSTM2GeneProduct
GSTM3GeneProductENSBTAG00000001842 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134202
GSTM5GeneProduct
GSTP1GeneProductENSBTAG00000003548 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084207
GSTT1GeneProduct
GSTT1GeneProductENSBTAG00000040298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099984
HBEGFGeneProductENSBTAG00000021766 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113070
HGFGeneProductENSBTAG00000017664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991
HMOX1GeneProductENSBTAG00000015582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100292
HSP90AA1GeneProductENSBTAG00000006270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080824
HSP90AB1GeneProductENSBTAG00000047699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096384
HSPA1AGeneProductENSBTAG00000025441 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204389
KEAP1GeneProductENSBTAG00000003543 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079999
LigandMetaboliteCHEBI:48705 (ChEBI)
MAFFGeneProductENSBTAG00000021435 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185022
MAFGGeneProductENSBTAG00000000040 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197063
ME1GeneProductENSBTAG00000005681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065833
MGST2GeneProductENSBTAG00000021779 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085871
MGST3GeneProductENSBTAG00000010265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143198
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116044
NQO1GeneProductENSBTAG00000020632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181019
PDGFBGeneProductENSBTAG00000021697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311
PGDGeneProductENSBTAG00000013527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142657
PPARDGeneProductENSBTAG00000017542 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112033
PRDX1GeneProductENSBTAG00000003642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117450
PRDX6GeneProductENSBTAG00000004855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117592
PTGR1GeneProductENSBTAG00000011027 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106853
RXRAGeneProductENSBTAG00000017851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186350
SERPINA1GeneProductENSBTAG00000018843 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197249
SGLT1GeneProductENSBTAG00000012851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100170
SLC2A10GeneProductENSBTAG00000002942 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197496
SLC2A11GeneProductENSBTAG00000018647 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133460
SLC2A12GeneProductENSBTAG00000019002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146411
SLC2A13GeneProductENSBTAG00000043962 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151229
SLC2A1GeneProductENSBTAG00000009617 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117394
SLC2A2GeneProductENSBTAG00000005386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163581
SLC2A3GeneProductENSBTAG00000004556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000059804
SLC2A4GeneProductENSBTAG00000009190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181856
SLC2A5GeneProductENSBTAG00000007302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142583
SLC2A6GeneProductENSBTAG00000001824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160326
SLC2A7GeneProduct
SLC2A8GeneProductENSBTAG00000006957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136856
SLC2A9GeneProductENSBTAG00000039197 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109667
SLC39A10GeneProductENSBTAG00000016782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196950
SLC39A11GeneProductENSBTAG00000018837 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133195
SLC39A12GeneProductENSBTAG00000015525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148482
SLC39A13GeneProductENSBTAG00000019436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165915
SLC39A14GeneProductENSBTAG00000019225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104635
SLC39A1GeneProductENSBTAG00000011284 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143570
SLC39A2GeneProductENSBTAG00000000936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165794
SLC39A3GeneProductENSBTAG00000017706 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141873
SLC39A4GeneProductENSBTAG00000046026 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147804
SLC39A5GeneProductENSBTAG00000002799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139540
SLC39A6GeneProductENSBTAG00000000998 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141424
SLC39A7GeneProductENSBTAG00000008191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112473
SLC39A8GeneProductENSBTAG00000005668 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138821
SLC39A9GeneProductENSBTAG00000017811 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000029364
SLC5A10GeneProductENSBTAG00000003700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154025
SLC5A11GeneProductENSBTAG00000003467 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158865
SLC5A12GeneProductENSBTAG00000021858 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148942
SLC5A2GeneProductENSBTAG00000010096 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140675
SLC5A3GeneProduct
SLC5A4GeneProductENSBTAG00000008117 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100191
SLC5A5GeneProductENSBTAG00000015830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105641
SLC5A6GeneProductENSBTAG00000006832 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138074
SLC5A7GeneProductENSBTAG00000004352 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115665
SLC5A9GeneProductENSBTAG00000014225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117834
SLC6A11GeneProductENSBTAG00000038962 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132164
SLC6A13GeneProductENSBTAG00000014525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000010379
SLC6A14GeneProduct
SLC6A15GeneProductENSBTAG00000018432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072041
SLC6A16GeneProductENSBTAG00000030543 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000063127
SLC6A17GeneProductENSBTAG00000001981 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197106
SLC6A18GeneProductENSBTAG00000012559 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164363
SLC6A19GeneProductENSBTAG00000045695 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174358
SLC6A1GeneProductENSBTAG00000005857 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157103
SLC6A20GeneProductENSBTAG00000031340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163817
SLC6A2GeneProductENSBTAG00000003353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103546
SLC6A3GeneProductENSBTAG00000015843 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142319
SLC6A4GeneProductENSBTAG00000019349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108576
SLC6A5GeneProductENSBTAG00000014300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165970
SLC6A6GeneProductENSBTAG00000011088 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131389
SLC6A7GeneProductENSBTAG00000000910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000011083
SLC6A8GeneProductENSBTAG00000009959 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130821
SLC6A9GeneProductENSBTAG00000006043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196517
SLC7A11GeneProductENSBTAG00000034075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151012
SMCT1GeneProductENSBTAG00000011525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000256870
SQSTM1GeneProductENSBTAG00000015591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161011
SRXN1GeneProduct
TGFAGeneProductENSBTAG00000000783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163235
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
TGFB2GeneProductENSBTAG00000005359 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000092969
TGFBR2GeneProductENSBTAG00000019832 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163513
TXNGeneProductENSBTAG00000002953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136810
TXNRD1GeneProductENSBTAG00000013912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198431
TXNRD3GeneProduct
UGT1A1GeneProductENSBTAG00000026181 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241635
UGT1A3GeneProductENSBTAG00000048275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243135
UGT1A4GeneProductENSBTAG00000048275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000244474
UGT1A6GeneProduct
UGT1A7GeneProduct
UGT1A9GeneProduct
UGT2B7GeneProductENSBTAG00000040337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171234

Annotated Interactions

No annotated interactions
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