Liver X Receptor Pathway (Bos taurus)

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9TranscriptionDrug and steroid metabolismTranscription factorsOtherMulti-drug resistanceNR1H320LXR ligandNR1H3LigandGenesTATA boxNR1H3LigandLXRERXRA5, 24RXRA5, 24ABCG820CYP3A421ABCG5CYP2B62021CYP7A1SREBF12121FASNLXR target genes21SCD


Description

The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2874(79886) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  14. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed
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  17. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed
  18. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed
  19. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed
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  23. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed
  24. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed
  25. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed
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  34. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed
  35. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed
  36. Nilsson S, Gustafsson JÅ; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed
  37. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed
  38. Lindsey S, Papoutsakis ET; ''''; , PubMed
  39. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed
  40. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed
  41. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed
  42. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed
  43. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed
  44. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed
  45. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed
  46. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed
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History

CompareRevisionActionTimeUserComment
88693view15:56, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
80770view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCG5GeneProductENSBTAG00000016365 (Ensembl)
  • ATP-binding cassette, sub-family G (WHITE), member 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
ABCG8GeneProductENSBTAG00000016366 (Ensembl)
  • ATP-binding cassette, sub-family G (WHITE), member 8
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
CYP2B6GeneProductENSBTAG00000003871 (Ensembl)
  • cytochrome P450, family 2, subfamily B, polypeptide 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1555
CYP3A4GeneProductENSBTAG00000047379 (Ensembl)
  • cytochrome P450, family 3, subfamily A, polypeptide 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP7A1GeneProductENSBTAG00000005287 (Ensembl)
  • cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
FASNGeneProductENSBTAG00000015980 (Ensembl)
  • fatty acid synthase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194
LXR ligandMetaboliteCHEBI:48705 (ChEBI) T3
LigandMetaboliteCHEBI:48705 (ChEBI)
NR1H3GeneProductENSBTAG00000010681 (Ensembl)
  • nuclear receptor subfamily 1, group H, member 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10062
RXRAGeneProductENSBTAG00000017851 (Ensembl)
  • retinoid X receptor, alpha
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319
SREBF1GeneProductENSBTAG00000007884 (Ensembl)
  • sterol regulatory element binding transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6720

Annotated Interactions

No annotated interactions
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