Colchicine Metabolic Pathway (Bos taurus)

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1, 221Colchicine3DMC12DMCCYP3A4


Description

P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2536(74479) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC
  2. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichov√° J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
80769view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
2DMCMetabolite22210 (Chemspider)
3DMCMetabolite264748 (Chemspider)
CYP3A4ProteinENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08684
ColchicineMetabolite5933 (Chemspider)

Annotated Interactions

No annotated interactions
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