Structural Pathway of Interleukin 1 (IL-1) (Bos taurus)

From WikiPathways

Revision as of 09:09, 25 July 2016 by Mkutmon (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
2-81RELAIL1,8,6, TNFa, IFNg, COX2, iNOSMBPIRAK2IRAK4HSP27ModificationMAPK11ELK1BIKBAMEKK3B-defensin2 etcMAP3K7TranslationIRAK1MYD88IL1R1cyclinD1etc.CHUKMAP3K8NF-kappaB p50CellCycleMAP3K1MAP3K7IP1MAPKAPK2IRF7NFKB1MAPK8TOLLIPTRAF6MAP2K3RPS6KA5MAPK3IFNalpha/betaMAP3K14IL1AIL1AIL1RAPTAB2TAB3MAP2K6MAP2K4MAP2K7MAP2K1MAP2K2TANKIKBKBMAPK14MAPK9MAPK10MAPK1NFKBIBATF2MKNK1MAPK9FOSc-MycMKNK2CREB341Histone H3EIF4E


Description

Pathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470

IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions and the resulting cellular events. The colored nodes represent proteins having experimentally identified 3D structures and the white nodes are the proteins without 3D structures. The edges represent protein-protein interactions (straight/dashed arrows relate to available/unavailable 3D structures of proteins) or associations leading to cellular events such as cell cycle or gene expression (dashed arrows beginning with circular heads).

doi:10.1371/journal.pcbi.1003470.g002

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2637(80029) with a 90.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM; ''O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.''; EMBO J, 2012 PubMed Europe PMC
  2. Pizarro TT, Cominelli F; ''Cloning IL-1 and the birth of a new era in cytokine biology.''; J Immunol, 2007 PubMed Europe PMC
  3. Martinon F, Mayor A, Tschopp J; ''The inflammasomes: guardians of the body.''; Annu Rev Immunol, 2009 PubMed Europe PMC
  4. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR; ''A new nomenclature for IL-1-family genes.''; Trends Immunol, 2001 PubMed Europe PMC
  5. Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O; ''The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer.''; PLoS Comput Biol, 2014 PubMed Europe PMC
  6. Lawson C, Al-Akoum M, Maheux R, Akoum A; ''Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions.''; Reproduction, 2007 PubMed Europe PMC
  7. Chang L, Karin M; ''Mammalian MAP kinase signalling cascades.''; Nature, 2001 PubMed Europe PMC
  8. Dunn E, Sims JE, Nicklin MJ, O'Neill LA; ''Annotating genes with potential roles in the immune system: six new members of the IL-1 family.''; Trends Immunol, 2001 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
87709view09:09, 25 July 2016MkutmonOntology Term : 'interleukin-1 signaling pathway' added !
87593view08:05, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
80756view15:24, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF2GeneProductENSBTAG00000002295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115966
B-defensin2
etc
Pathway
BIKBAGeneProductENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P25963
CHUKGeneProductENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341
CREB341GeneProduct
Cell CyclePathway
EIF4EGeneProductENSBTAG00000009522 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151247
ELK1GeneProductENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126767
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
HSP27GeneProductENSBTAG00000035584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160633
Histone H3GeneProduct
IFNalpha/betaPathway
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365
IL1,8,6, TNFa, IFNg, COX2, iNOSPathway
IL1AGeneProductENSBTAG00000010349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115008
IL1R1GeneProductENSBTAG00000005273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115594
IL1RAPGeneProductENSBTAG00000013205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196083
IRAK1GeneProductENSBTAG00000016085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184216
IRAK2GeneProductENSBTAG00000006193 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134070
IRAK4GeneProductENSBTAG00000021105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198001
IRF7GeneProductENSBTAG00000047680 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185507
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126934
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000034152
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065559
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108984
MAP2K7GeneProductENSBTAG00000010639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076984
MAP3K14GeneProductENSBTAG00000007084 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095015
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135341
MAP3K7IP1GeneProductENSBTAG00000019828 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100324
MAP3K8GeneProductENSBTAG00000011600 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107968
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53779
MAPK11GeneProductENSBTAG00000030182 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185386
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112062
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102882
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P45983
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000050748
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162889
MBPGeneProductENSBTAG00000022890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
MEKK3GeneProduct
MKNK1GeneProductENSBTAG00000019933 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079277
MKNK2GeneProductENSBTAG00000018049 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099875
MYD88GeneProductENSBTAG00000000563 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172936
ModificationPathway
NF-kappaB p50GeneProduct
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P19838
NFKBIBGeneProductENSBTAG00000001778 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15653
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100784
TAB2GeneProductENSBTAG00000013454 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000055208
TAB3GeneProductENSBTAG00000048159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157625
TANKGeneProductENSBTAG00000006654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136560
TOLLIPGeneProductENSBTAG00000008237 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078902
TRAF6GeneProductENSBTAG00000036009 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175104
TranslationPathway
c-MycGeneProduct
cyclinD1 etc.Pathway

Annotated Interactions

No annotated interactions
Personal tools