Hematopoietic Stem Cell Differentiation (Bos taurus)

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1FOSLMO2LEF1SPI1CD34GATA2IRF5HMGN5IKZF1CDH1KLF1TRIM29CBFA2T3CIITAMUC1RHOHHES6KCNH2PIM1LYL1FOSBIL5NCKAP1LTNXBVAV1ZNF835CSF3NFATC2TRAF3IP3STAT5ASEC14L2CSF1THRBMYBLMO2GATA1RUN1T1PBX1HLFPRDM5ZFP37KITLGTPOIL3EPOErythrocyteHematopoietic Stem Cell (HSC)MyeloblastMegakaryocyteCommon MyeloidProgenitorIL6IL1ACSF2IL1BKITLGIL3CSF2CSF2CXCR43MXI1RIOK3ACVR1BMIR15A3bta-mir-223MIR17MIR24AMIR155bta-mir-181a-1bta-mir-128-1MIR10Abta-mir-130aiHSC ReprogrammingFactorsMegakaryocyte-ErythrocytePrecursor (MEP)bta-mir-16a2MIR4512bta-mir-2212bta-mir-221bta-mir-1502TPO2TPOErythrocyte ProgenitorPlateletsGATA1GATA1GATA1ABOITGA2BGP9CD34CD235aSPI1RUNX1NOTCH1bta-mir-223MIR155bta-mir-223MIR155MEP TranscriptionFactor MarkersErythrocyte TranscriptionFactor MarkersMEP-Erythocyte CommonTranscription FactorsFLI1UM279ITGA2BGATA22NFE2INTB3LOXL3TXKGATA5WNT11HEXIM1ZGLP1EGFTGFB1LBX2ELF1ZNF792RCAN1FLI1HEXIM2NLKMED12LZNF789F2RPADI4MEF2CCRLF3PIM2Megakaryocyte TranscriptionFactor MarkersEosinophilBasophilNeutrophilMonocyteIL3IL6KITLGCSF2CSF3IL3IL6KITLGCSF2CSF2IL3IL3IL6KITLGCSF2


Description

Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2849(78586) with a 50.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ; ''Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.''; Cell, 2014 PubMed Europe PMC
  2. Slavov SN, Gimenes Teixeira HL, Rego EM; ''The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis.''; Braz J Med Biol Res, 2010 PubMed Europe PMC
  3. Zhang L, Sankaran VG, Lodish HF; ''MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.''; Leukemia, 2012 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
89817view11:53, 6 October 2016MkutmonModified description
80751view15:24, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABOGeneProductENSBTAG00000012525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175164
ACVR1BGeneProductENSBTAG00000013555 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135503
CBFA2T3GeneProductENSBTAG00000010927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129993
CD235aGeneProduct
CD34GeneProduct
CDH1GeneProduct
CIITAGeneProduct
CRLF3GeneProduct
CSF1GeneProductENSBTAG00000000283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371
CSF2GeneProductENSBTAG00000001570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400
CSF3GeneProductENSBTAG00000021462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108342
CXCR4GeneProductENSBTAG00000001060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121966
EGFGeneProduct
ELF1GeneProduct
EPOGeneProductENSBTAG00000003430 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427
F2RGeneProduct
FLI1GeneProduct
FOSBGeneProduct
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
GATA1GeneProductENSBTAG00000003184 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102145
GATA2GeneProduct
GATA2GeneProductENSBTAG00000019707 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179348
GATA5GeneProduct
GP9GeneProductENSBTAG00000014666 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169704
HES6GeneProduct
HEXIM1GeneProduct
HEXIM2GeneProduct
HLFGeneProduct
HMGN5GeneProduct
IKZF1GeneProductENSBTAG00000014016 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185811
IL1AGeneProductENSBTAG00000010349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115008
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
IL3GeneProduct
IL5GeneProductENSBTAG00000031235 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113525
IL6GeneProductENSBTAG00000014921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
INTB3GeneProductENSBTAG00000009987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
IRF5GeneProduct
ITGA2BGeneProductENSBTAG00000008165 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000005961
KCNH2GeneProductENSBTAG00000004078 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000055118
KITLGGeneProductENSBTAG00000017549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130
KLF1GeneProductENSBTAG00000006083 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105610
LBX2GeneProduct
LEF1GeneProduct
LMO2GeneProduct
LMO2GeneProductENSBTAG00000006951 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135363
LOXL3GeneProduct
LYL1GeneProductENSBTAG00000019329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104903
MED12LGeneProduct
MEF2CGeneProduct
MIR10ARna
MIR155Rna
MIR15AGeneProduct
MIR17Rna
MIR24ARna
MIR451GeneProduct
MUC1GeneProduct
MXI1GeneProductENSBTAG00000017263 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119950
MYBGeneProductENSBTAG00000012074 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118513
NCKAP1LGeneProductENSBTAG00000019686 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123338
NFATC2GeneProductENSBTAG00000018270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101096
NFE2GeneProductENSBTAG00000001562 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123405
NLKGeneProduct
NOTCH1GeneProductENSBTAG00000022799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
PADI4GeneProduct
PBX1GeneProduct
PIM1GeneProduct
PIM2GeneProduct
PRDM5GeneProduct
RCAN1GeneProduct
RHOHGeneProduct
RIOK3GeneProductENSBTAG00000010042 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101782
RUN1T1GeneProduct
RUNX1GeneProductENSBTAG00000004742 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159216
SEC14L2GeneProduct
SPI1GeneProductENSBTAG00000021709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066336
STAT5AGeneProductENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126561
TGFB1GeneProduct
THRBGeneProduct
TNXBGeneProduct
TPOGeneProduct
TRAF3IP3GeneProduct
TRIM29GeneProductENSBTAG00000009419 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137699
TXKGeneProduct
UM279Metabolite
  • http://www.google.com/patents/CA2862140A1?cl=en
  • Patented derivative of Pyrimido[4,5-b]indole
VAV1GeneProductENSBTAG00000039160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141968
WNT11GeneProduct
ZFP37GeneProduct
ZGLP1GeneProduct
ZNF789GeneProduct
ZNF792GeneProduct
ZNF835GeneProduct
bta-mir-128-1RnaENSBTAG00000029990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207654
bta-mir-130aRnaENSBTAG00000030122 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000208009
bta-mir-150RnaENSBTAG00000030068 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207782
bta-mir-16aGeneProductENSBTAG00000036389 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000208006
bta-mir-181a-1RnaENSBTAG00000029849 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207759
bta-mir-221RnaENSBTAG00000029803 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207870
bta-mir-223RnaENSBTAG00000036418 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207939

Annotated Interactions

No annotated interactions
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