FSH signaling pathway (Bos taurus)

From WikiPathways

Jump to: navigation, search
SteroidogenesisFSH Signaling PathwayMAPK1PFSHBFSHRCGAMAPK3AKT1PPFSHBCGARPS6TSC2PCREB1PPHIST3H3PRPS6KB1FOXO1DePMAPK14PGRK6PRPS6KB2RAF1PEIF4EBP1PPSRCSGK1PPMTORPAPPL1PRKCACYP19A1PRKACAAREGBDNFRHEBFSHRPProteinProteinmRNALigandReceptorProteinProtein - protein dissociationEnzyme ComplexSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMolecule


Description

The Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH) and Chorionic Gonadotropin. FSH controls the growth and maturation of follicles in the females and spermatogenesis in males. FSH is a heterodimer and shares a common alpha sub-unit with the other glycoprotein hormones in its family and has a specific beta subunit that confers receptor specificity and biological activity to the hormone. FSH acts through the FSH receptor (FSHR), a G protein coupled receptor that is expressed exclusively on the granulosa cells of ovaries and Sertoli cells of the testis in humans. FSH signaling involves activation of adenylyl cyclase activity and the increased production of cAMP. This activates the cAMP dependent protein kinases such as PKA, PKB and PKC that, in turn, lead to the phosphorylation of specific transcription factors such as cAMP response element binding protein (CREB) and Forkhead box protein O1 (FOXO1). In addition to activation of PI3K/Akt module, PKA also induces p38 mapk which, in turn, controls other kinase cascades. Activated Akt also induces the mTOR axis that stimulates mRNA translation by phosphorylating p70 S6 kinase and, consequently, the 40 S ribosomal protein S6 that results in the activation of eukaryotic initiation factor (eIF) 4E. It also indirectly aids in the activation of extracellular signal-regulated protein kinases (ERKs). FSH induces important genes required for steroidogenesis as well as growth and maturation of germ cells. The important target genes include aromatase (CYP19A1), the lutenizing hormone receptor (LHR) and the vascular endothelial growth factor (VEGF).

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper: Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., Prasad, T. S. K., Ramachandra, Y. L., Mohan, S. S., Maharudraiah, J., Mukherjee, S. and Pandey, A. (2011). A comprehensive curated resource for Follicle Stimulating Hormone signaling. BMC Research Notes. 4, 408.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2035(78536) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

CompareRevisionActionTimeUserComment
80724view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
APPL1ProteinENSBTAG00000006824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26060
AREGRnaENSBTAG00000018134 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:374
BDNFRnaENSBTAG00000008134 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:627
CGAProteinENSBTAG00000016138 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1081
CREB1ProteinENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CYP19A1RnaENSBTAG00000014890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1588
EIF4EBP1ProteinENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
FOXO1ProteinENSBTAG00000044105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2308
FSHBProteinENSBTAG00000039236 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2488
FSHRProteinENSBTAG00000032424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2492
GRK6ProteinENSBTAG00000043994 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2870
HIST3H3ProteinENSBTAG00000031721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8290
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3ProteinENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MTORProteinENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
PRKACAProteinENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
PRKCAProteinENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RHEBProteinENSBTAG00000031861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6009
RPS6ProteinENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KB1ProteinENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
RPS6KB2ProteinENSBTAG00000009175 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6199
SGK1ProteinENSBTAG00000004269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6446
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
TSC2ProteinENSBTAG00000020617 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7249

Annotated Interactions

No annotated interactions
Personal tools