Apoptosis Modulation and Signaling (Bos taurus)

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12DNAApoptotic factors"Amplification loop"Modulation of apoptosisApoptosomeTRAFsPIDDosomeDNA-FragmentationActivation of Caspases- extrinsic pathwayMitochondriaCa2+MAPK8MIR29B1BIRC3IL1R1JUNBIKBADAXXBIRC5BCL2A1CASP2APAF1BOKIKBKBBCL2L11BAXTOLLIPTNFRSF11BIL1R2MADDFLIPAIFM1TRADDFASLGTRAF6CASP3TRADDCASP13MAP3K14TNFRSF25MAPK3MYD88CASP6TNFRSF1BCASP2CRADDSEPT4CASP9CASP1CDKN2ABLKBAG3HSPA1APIDD1BIRC6BIKCYCSMAP3K5BADBCL2L2JUNBID2TP53CASP7MAPK8TNFRSF1AHRKPRKD1FLIPHN1NAIPXIAPCAPNS1AIFM2TNFRSF1AIL1R1MCL1BMFTNFRSF25TNFRSF6BPTRH2RIPK1PTPN13TNFRSF10DENDOGCASP2TNFSF10BAK1HTRA2DFFABNIP3BIRC5PEA15CASP10FOSBcl-BFADDDFFBFASCASP8TNFRSF10DBCL2CASP8DIABLOIRAK1MADDNFKB1TNFRSF10DRIPK1BCL2L1TNFRSF1ATRAF3BCL2L1BIRC2TRADDBIRC7FASPumaTNFRSF10DNoxaThe interactions of this pathway were computationally validated. See reference.DISCActivation of Caspases- intrinsic pathwayMIR29B2


Description

Apoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both

resulting in an activation of caspases. In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as "amplification loop".

Comments

GenMAPP notes 
Rأ¼ckert F et al. Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis.

PLoS ONE, 2010. 5: e12243

GenMAPP remarks 
Arrows: activation, broken arrows: inhibtion
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1772(80459) with a 90.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Rأ¼ckert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, Schroeder M, Schackert HK, Sipos B, Klأ¶ppel G, Kalthoff H, Saeger HD, Pilarsky C, Grأ¼tzmann R; ''Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis.''; PLoS One, 2010 PubMed
  2. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed

History

View all...
CompareRevisionActionTimeUserComment
96010view10:07, 15 February 2018DeSlRemoved licence number
96009view10:04, 15 February 2018DeSlChanged MIMconversion between metabolite and gene to Arrow.
87363view09:48, 22 July 2016MaintBotadded missing graphids
85871view10:20, 19 June 2016EgonwReplaced mim-conversions with Arrows.
80711view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AIFM1GeneProductENSBTAG00000006838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131
AIFM2GeneProductENSBTAG00000001165 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84883
APAF1GeneProductENSBTAG00000021661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:APAF1
BADGeneProductENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAD
BAG3GeneProductENSBTAG00000013641 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAG3
BAK1GeneProductENSBTAG00000000428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAK1
BAXGeneProductENSBTAG00000013340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAX
BCL2A1GeneProductENSBTAG00000000735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2A1
BCL2GeneProductENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2
BCL2L11GeneProductENSBTAG00000024105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L11
BCL2L1GeneProductENSBTAG00000006526 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L1
BCL2L2GeneProductENSBTAG00000019692 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L2
BID2GeneProductENSBTAG00000013988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BID
BIKGeneProduct
BIKBAGeneProductENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKBIA
BIRC2GeneProductENSBTAG00000035735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC2
BIRC3GeneProductENSBTAG00000024918 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC3
BIRC5GeneProductENSBTAG00000013573 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC5
BIRC6GeneProductENSBTAG00000027932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC6
BIRC7GeneProductENSBTAG00000004911 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC7
BLKGeneProductENSBTAG00000005049 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BLK
BMFGeneProductENSBTAG00000012180 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BMF
BNIP3GeneProductENSBTAG00000017804 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BNIP3
BOKGeneProductENSBTAG00000008711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BOK
Bcl-BGeneProductENSBTAG00000033967 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L10
CAPNS1GeneProductENSBTAG00000014872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CAPNS1
CASP1GeneProduct
CASP10GeneProduct
CASP13GeneProductENSBTAG00000020884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:837
CASP2GeneProduct
CASP2GeneProductENSBTAG00000018159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP2
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP3
CASP6GeneProductENSBTAG00000012537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP6
CASP7GeneProductENSBTAG00000006615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP7
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP8
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP9
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CDKN2A
CRADDGeneProductENSBTAG00000005107 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CRADD
CYCSGeneProductENSBTAG00000022613 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CYCS
Ca2+MetaboliteHMDB00464 (HMDB)
DAXXGeneProductENSBTAG00000016830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DAXX
DFFAGeneProductENSBTAG00000013535 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DFFA
DFFBGeneProductENSBTAG00000020015 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DFFB
DIABLOGeneProductENSBTAG00000004199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DIABLO
ENDOGGeneProductENSBTAG00000012484 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:ENDOG
FADDGeneProductENSBTAG00000018274 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FADD
FASGeneProductENSBTAG00000010785 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FAS
FASLGGeneProductENSBTAG00000032808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FASLG
FLIPGeneProductENSBTAG00000010998 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CFLAR
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FOS
HN1GeneProductENSBTAG00000030170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HN1
HRKGeneProductENSBTAG00000047484 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HRK
HSPA1AGeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000025441;En:ENSBTAG00000025441;
HTRA2GeneProductENSBTAG00000020124 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HTRA2
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IKBKB
IL1R1GeneProductENSBTAG00000005273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IL1R1
IL1R2GeneProductENSBTAG00000006343 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IL1R2
IRAK1GeneProductENSBTAG00000016085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IRAK1
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:JUN
MADDGeneProductENSBTAG00000021700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MADD
MAP3K14GeneProductENSBTAG00000007084 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAP3K14
MAP3K5GeneProductENSBTAG00000009065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAP3K5
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK3
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK8
MCL1GeneProductENSBTAG00000031396 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MCL1
MIR29B1Rna
MIR29B2GeneProduct
MYD88GeneProductENSBTAG00000000563 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MYD88
NAIPGeneProductENSBTAG00000003326 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4671
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKB1
NoxaGeneProduct
PEA15GeneProductENSBTAG00000005793 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8682
PIDD1GeneProductENSBTAG00000019634 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55367
PRKD1GeneProductENSBTAG00000012789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
PTPN13GeneProductENSBTAG00000014947 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PTPN13
PTRH2GeneProductENSBTAG00000016710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PTRH2
PumaGeneProduct
RIPK1GeneProductENSBTAG00000006378 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
SEPT4GeneProductENSBTAG00000015368 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:SEPT4
TNFRSF10DGeneProductENSBTAG00000047389 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10C
TNFRSF11BGeneProductENSBTAG00000007423 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF11B
TNFRSF1AGeneProductENSBTAG00000004211 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF1A
TNFRSF1BGeneProductENSBTAG00000024928 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF1B
TNFRSF25GeneProductENSBTAG00000006519 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF25
TNFRSF6BGeneProductENSBTAG00000027407 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF6B
TNFSF10GeneProductENSBTAG00000018994 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFSF10
TOLLIPGeneProductENSBTAG00000008237 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TOLLIP
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
TRADDGeneProductENSBTAG00000012642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRADD
TRAF3GeneProductENSBTAG00000013475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRAF3
TRAF6GeneProductENSBTAG00000036009 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRAF6
XIAPGeneProduct

Annotated Interactions

No annotated interactions
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