NOD pathway (Bos taurus)

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1transcriptional reg./cleavageMuramyl Dipeptidee.g. Bacillus anthracis cleavesCleavesdirect bindingStimulantInhibitorActivated by Flagellin from L. pneumophila,S. typhimurium, Shigella flexneri, or P. aeruginosaInflammasomecleavesdownregulatesUpregulatesNigericin, Maitotoxin, Aerolysin(pore forming toxins)Asbestos, Silica Gram +ve L. monocytogenesS. aureus, M. marinum, ATPMeso-DAP cleavesMuramyl Dipeptide &ATP induce Oligomerization Restriction of L. pneumophila infectionHSP90AA1CASP7RAC1XIAPAIM2NLRP7ERBB2IPACAP1IKBKBCARD6IL1BCASP13NLRP1MEFVIKBKGNLRP2CASP1NOD1BIKBACARD9COPS6AAMPNLRP4CASP9NLRC4CHUKCARD8Nf-kappa B signalingPRDM1SUGT1NDUFA13NLRP10NLRP3RIPK2NAIPIL18NOD2NLRP12CASP8PYCARDDUOX2RELA


Description

The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1433(80018) with a 80.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Strober W, Murray PJ, Kitani A, Watanabe T; ''Signalling pathways and molecular interactions of NOD1 and NOD2.''; Nat Rev Immunol, 2006 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
80709view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AAMPGeneProductENSBTAG00000003927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127837
ACAP1GeneProductENSBTAG00000010527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072818
AIM2GeneProduct
BIKBAGeneProductENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100906
CARD6GeneProductENSBTAG00000014374 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132357
CARD8GeneProduct
CARD9GeneProductENSBTAG00000006572 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187796
CASP1GeneProduct
CASP13GeneProductENSBTAG00000020884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137757
CASP7GeneProductENSBTAG00000006615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165806
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064012
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132906
CHUKGeneProductENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341
COPS6GeneProductENSBTAG00000002871 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168090
DUOX2GeneProductENSBTAG00000016234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140279
ERBB2IPGeneProductENSBTAG00000000415 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112851
HSP90AA1GeneProductENSBTAG00000006270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080824
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365
IKBKGGeneProduct
IL18GeneProductENSBTAG00000000277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150782
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
MEFVGeneProductENSBTAG00000019123 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103313
NAIPGeneProductENSBTAG00000003326 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4671
NDUFA13GeneProduct
NLRC4GeneProductENSBTAG00000008223 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091106
NLRP10GeneProduct
NLRP12GeneProductENSBTAG00000038149 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142405
NLRP1GeneProductENSBTAG00000020433 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091592
NLRP2GeneProductENSBTAG00000047473 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000022556
NLRP3GeneProductENSBTAG00000001273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162711
NLRP4GeneProduct
NLRP7GeneProductENSBTAG00000047473 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167634
NOD1GeneProductENSBTAG00000038235 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106100
NOD2GeneProductENSBTAG00000020936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167207
Nf-kappa B signalingPathwayWP231 (WikiPathways)
PRDM1GeneProductENSBTAG00000000816 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000057657
PYCARDGeneProductENSBTAG00000020535 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103490
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136238
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039
RIPK2GeneProductENSBTAG00000015271 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104312
SUGT1GeneProductENSBTAG00000002137 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165416
XIAPGeneProduct

Annotated Interactions

No annotated interactions
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