DNA Damage Response (only ATM dependent) (Bos taurus)

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111111111111UV radiation --> DNA damageCaption:MetabolismExtra cellularspaceCellProliferationPDifferent PathwayPI3KBCRMetabolitePhosphorylatedGene productDNA damage sourceFrizzled Ligandsmitoch-ondriumTCF-1/LEFOsxidative StressresistanceInhibitionActivationRASNucleusTCRExtra cellularspcaceCytokine receptorChange in the Cell conditionCellMembraneOrigin DNA damageresponseRBL2PIK3CAAXIN1AKT3BADWNT2BPIK3C2GWNT2WNT16CCND1WNT3Cell CycleMAP3K4TCFL2GRB2MAPK9PIK3CBRAC3MAP3K1NFKB1APCApoptosis HMGB1WNT1RAC2Apoptosis WNT10BFOXO3WNT7BCDKN2ADVL2WNT16PMAIP1MYCHRASPIK3CGMYCAKT1AKT3CDKN1BPIK3C2AWNT6WNT5BABL1AKT2LEF1SCP2CTNNB1SOS2FOSL1PPP2R5EMAPK8WNT11BCL2DVL1PIK3R5KRASBIKRAC1PIK3R3PIK3C2BBCL6SOS1PIK3R1Cell CyclePPP2R5CMAPK1MLKLWNT7ASOD2PLAUBAK1BBC3Apoptosis GSK3BG6PCTGFB1FASLGWNT10AAKT1JUNAPCAKT2TP53PIK3R4PIK3C3TCF7L1PDK1WNT4PTENMAPK9TGFB1SHC1NFKB2LDLRFRAT1PIK3R2CATCCND3BCL2L11ERBB2CCND2IRS1NRASRHOADNA damage responseBCL2L11BAXDVL3Apoptosis IR-ATP73RAC1MAP3K7SMAD3WNT5ACDKN1APIK3CDTCF7PCK2BBC3MDM2MAPK10WNT3ACCNG2ATMCDC42SMAD4


Description

This is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway.

In this pathway is only one source of DNA damage induction because most sources and their induction and involvement in the process in DNA damage are mentioned in the first DNA damage response pathway. If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this second pathway is to mention more gene products and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP710(79974) with a 94.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC
  2. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC
  3. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC
  4. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC
  5. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC
  6. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC
  7. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC
  8. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC
  9. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC
  10. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC
  11. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC
  12. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnأ¯آ؟آ½أ¯آ؟آ½أژآ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC
  13. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC
  14. Lأ¯آ؟آ½أ¯آ؟آ½أژآ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC
  15. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC
  16. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC
  17. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC

History

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80705view15:22, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000097007
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:AKT1
AKT2GeneProductENSBTAG00000001400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:AKT2
AKT3GeneProductENSBTAG00000017788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:AKT3
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
ATMGeneProductENSBTAG00000003111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149311
AXIN1GeneProductENSBTAG00000016577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
Apoptosis PathwayWP254 (WikiPathways)
BADGeneProductENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000002330
BAK1GeneProductENSBTAG00000000428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000030110
BAXGeneProductENSBTAG00000013340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087088
BBC3GeneProduct
BCL2GeneProductENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171791
BCL2L11GeneProductENSBTAG00000024105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000153094
BCL6GeneProductENSBTAG00000001511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113916
BIKGeneProduct
CATGeneProductENSBTAG00000020980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121691
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND2GeneProductENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCNG2GeneProductENSBTAG00000021768 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138764
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124762
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111276
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CDKN2A
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
Cell CyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP1530 (WikiPathways)
DVL1GeneProductENSBTAG00000010696 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
DVL2GeneProductENSBTAG00000003075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
DVL3GeneProductENSBTAG00000019336 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
ERBB2GeneProductENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141736
FASLGGeneProductENSBTAG00000032808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117560
FOSL1GeneProductENSBTAG00000006194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061
FOXO3GeneProductENSBTAG00000011234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118689
FRAT1GeneProductENSBTAG00000007956 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10023
G6PCGeneProductENSBTAG00000010184 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131482
GRB2GeneProductENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177885
GSK3BGeneProductENSBTAG00000048057 (Ensembl)
  • MOUSE:KG38 MOUSE
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
HMGB1GeneProductENSBTAG00000014862 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000189403
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IR-AGeneProductENSBTAG00000012687 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171105
IRS1GeneProductENSBTAG00000021308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169047
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KRASGeneProduct
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
LEF1GeneProductENSBTAG00000006844 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095015
MAP3K4GeneProductENSBTAG00000020079 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085511
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135341
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107643
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135679
MLKLGeneProductENSBTAG00000012216 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168404
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKB1
NFKB2GeneProductENSBTAG00000006017 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKB2
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
PCK2GeneProductENSBTAG00000011934 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5106
PDK1GeneProductENSBTAG00000016836 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152256
PIK3C2AGeneProductENSBTAG00000004901 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5286
PIK3C2BGeneProductENSBTAG00000024633 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5287
PIK3C2GGeneProductENSBTAG00000020715 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5288
PIK3C3GeneProductENSBTAG00000026290 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5289
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3CBGeneProductENSBTAG00000006909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5291
PIK3CDGeneProductENSBTAG00000018984 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293
PIK3CGGeneProductENSBTAG00000020848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PIK3R3GeneProductENSBTAG00000002979 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8503
PIK3R4GeneProductENSBTAG00000020787 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:30849
PIK3R5GeneProduct
PLAUGeneProductENSBTAG00000005947 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
PMAIP1GeneProduct
PPP2R5CGeneProductENSBTAG00000020192 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5527
PPP2R5EGeneProductENSBTAG00000019784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5529
PTENGeneProductENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171862
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAC2GeneProductENSBTAG00000011043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128340
RAC3GeneProductENSBTAG00000022927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:RAC3
RBL2GeneProductENSBTAG00000016243 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103479
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
SCP2GeneProductENSBTAG00000003746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116171
SHC1GeneProductENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160691
SMAD3GeneProductENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166949
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141646
SOD2GeneProductENSBTAG00000006523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112096
SOS1GeneProductENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115904
SOS2GeneProductENSBTAG00000005550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100485
TCF7GeneProductENSBTAG00000001002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6932
TCF7L1GeneProductENSBTAG00000010111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83439
TCFL2GeneProductENSBTAG00000021574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6934
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
TP73GeneProductENSBTAG00000005812 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078900
WNT10AGeneProductENSBTAG00000009217 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80326
WNT10BGeneProductENSBTAG00000015347 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7480
WNT11GeneProductENSBTAG00000010820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7481
WNT16GeneProductENSBTAG00000002940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51384
WNT1GeneProductENSBTAG00000015364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
WNT2BGeneProductENSBTAG00000014291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
WNT2GeneProductENSBTAG00000008097 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
WNT3GeneProductENSBTAG00000016012 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7473
WNT4GeneProductENSBTAG00000022671 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54361
WNT5AGeneProductENSBTAG00000020221 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
WNT5BGeneProductENSBTAG00000001341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81029
WNT6GeneProductENSBTAG00000013990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7475
WNT7AGeneProductENSBTAG00000001668 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7476
WNT7BGeneProductENSBTAG00000009532 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477

Annotated Interactions

No annotated interactions
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