BDNF signaling pathway (Bos taurus)

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VAV3MAPK9PCDK5R1SHC2MAPK8PMAPK3Y204T202ط®آ³-secretasecomplexCa2+ELMOEndocytosis-dependentOxidativeneuronalnecrosismembraneboundBrain-derived neurotrophic factor signaling pathwayIKKDegradationSelectivepostsynapticdevelopmentNeuriteoutgrowthReduction inphosphorylationLamellipodia formationand increasedneurite outgrowthSynaptic plasticityDissociationProteinsynthesisCHUKIKBKBIKBKGBCL2L11CYFIP1NCK1NCK2SHC1PPLCG1Y783PTPN11PCDH2TRAF6CTNNB1Y654SQSTM1FYNY420SHC3PNGFRNCAM1Y734TIAM1Y829LINGO1RANBP9DOK5PSHC4PGRB2SIRPB1PKCNA3PFRS2PGRIN2BPFRS3PDOCK3PNTRK1PRAC1CDKL5PSORT1NGFBDNFGRIA2CREB1S133NSFGNB2L1GABRB3S432S433PPP2CACRTC1KSR1MAP2K2PMAPK1T185Y187MAP2K1PSH2B2PFOXO3T32S253MTORS2448KIDINS220PRPS6KB1T412S447T444EIF4EBP1T46T37AKT1S473T308BADS75S99SH2B1PGSK3BS9GRIN1PIRS2PMAPK7T219Y221IRS1PTSC2T1462GRIA1PCAMK4PCAMK2APEEF2ACACBS78PRKAA2T172MAPTS202S198S195ELK1PIGF2BP1Y396PTK2BY402RAF1S338VAV2Y172CDK5Y15NFATC4NCF2NCF1NFATC4CYNUCYNUSTAT5BCDC42CNR1NTRK3PIK3R1NTF3BDNFPDPK1S241MAP3K1ADAM17MAPK10PHRASGTPRPS6S240S236S235S244EIF4EPPIK3R2IP3SRCFOXO3PIP2DAGSTAT5ANFKB1RELAS529NFKB1RELAS529BIKBAS36S32JUNPCASP3ProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through multiple reactionsTranslocation UbiquitinationPTM stateProtein-protein interactionDephosphorylationLEGENDPhosphorylationNucleusCytoplasmPlasma membraneCYPMNUProteolytic cleavageMoleculeCalcificationNeuronal growth,differentiation,and protectionInhibition ofapoptosisNitric oxideproductionApoptosisInhibition ofapoptosisRPS6KA3S227S386YBX1S102RPS6KA1S380S221RPS6KA5S376CAMK1T177MAPK14T180Y182RASGRF1DPYSL2T514APCPTPRFDLG1GRIP1GRIA3RHOGPAKKCNN2PCFL1PBDNFBDNFPIP2PIP3PIK3CACalmodulinSOSCAMKKCalcineurinPRKAA1T196EnhancedfatoxidationReduction in FOXO3 shuttleto nucleus anddecrease in BIMMAP2K5MAP3K2MEF2CMEF2ACerebellargranuleneuronalsurvivalCYNURAP1AMAPK7Y221T219CYNURegulation of surface expression of AMPA receptorsPKCRegulation ofsynaptic plasticitySTAT5BSTAT5AGrowthconemotilityCYNURegulation of Pre-synapticplasticity CYNUCYNUHuman airwaysmooth muscle cellproliferationRelease of RNG105from RNA granulesJAK2PSTAT1STAT3PPMajor pelvicganglia neuriteoutgrowthCREB1FOSEGR1EGR2Cortical dendrite differentiationMARCKSPPRKCDY311CDK5dependentregulation of CDC42activityRadial migrationof corticalneuronsNTRK2Y722S495NTRK2K811Y723In secretorygranulesROSGSK3BS9MicrotubuleassemblyCSNK2A1RAB3AGTPcAMPPKASPP1ALPLBMP2EIF2S1EIF2S2MAPK3Y204T202MAPK1T185Y187SYN1PNeurotransmitterreleasemembraneboundBDNFBDNFBDNFAutocrinesignalingExtracellularECRPS6KA5S376ECCYDendritic developmentAxonal growthand branchingp75 NTR


Description

Brain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, behavior, mental health, learning, memory, stress, pain and apoptosis. BDNF is implicated in various neuronal disorders such as Alzheimer's disease, Huntington's disease, depression, and bipolar disorder.

BDNF binds to tyrosine kinase receptor known as tropomyosin-related kinase B (TrkB). It also binds with low affinity to p75 neurotrophin receptor (p75NTR). BDNF and its receptors are expressed throughout the central and peripheral nervous system.

BDNF signaling is elicited when it dimerizes and binds to TrkB, resulting in the receptor dimerization and autophosphorylation. The activation of the receptor results in its interaction with molecules such as Shp2, Shc and PLC-gamma. These molecules further interact and modify their downstream targets leading to various neuronal processes. BDNF activates the signaling cascades such as PLC/PKC, PI3K/Akt, Ras/Erk, AMPK/ACC and NFκB pathways. BDNF through PLC/PKC pathway leads to release of intracellular calcium and regulation of synaptic plasticity. It also maintains synaptic plasticity through cAMP/PKA signaling. Activation of PI3K/Akt pathway through BDNF/TrkB interaction inhibits cell apoptosis by decreasing the expression of BIM. However, BDNF/p75NTR interaction activates JNK through TRAF6, which leads to apoptosis. Activation of JNK3 also leads to proteolytic cleavage of the p75NTR by TACE. PI3K/Akt also leads to activation of mTOR pathway and subsequently protein synthesis. Ras/Erk signaling is involved in cell proliferation, differentiation and protection of neurons. BDNF also leads to neuronal survival through Erk5/Mef pathway. Phosphorylation of synapsin by Erk1/2 leads to neurotransmitter release. BDNF signaling leads to nitric oxide production through NFκB pathway. BDNF induces neurite outgrowth through activation of JAK/STAT, Rac, and Cdc42 pathways. BDNF enhances oxidation of fat through AMPK mediated inhibition of ACC. It also plays role in microtubule assembly through inhibition of GSK3-beta. It leads to oxidative neuronal necrosis through activation of NCF molecules. BDNF also regulates the surface expression of AMPA and NMDA receptors. BDNF also regulates the expression of genes leading to processes such as differentiation of dendrites and calcification of cementoblast-like cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2380(79953) with a 96.0% conversion rate.

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History

CompareRevisionActionTimeUserComment
89804view11:38, 6 October 2016Mkutmonfixed special characters in description
80702view15:22, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACACBProteinENSBTAG00000022058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:32
ADAM17ProteinENSBTAG00000001141 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6868
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
ALPLRnaENSBTAG00000008951 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:249
APCProteinENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
BADProteinENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:572
BCL2L11RnaENSBTAG00000024105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10018
BDNFRnaENSBTAG00000008134 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:627
BIKBAProteinENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792
BMP2RnaENSBTAG00000005111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650
CAMK1ProteinENSBTAG00000007780 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8536
CAMK2AProteinENSBTAG00000020087 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:815
CAMK4ProteinENSBTAG00000035662 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:814
CASP3ProteinENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
CDC42ProteinENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CDH2ProteinENSBTAG00000021190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1000
CDK5ProteinENSBTAG00000007766 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1020
CDK5R1ProteinENSBTAG00000004475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8851
CDKL5ProteinENSBTAG00000007428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6792
CFL1ProteinENSBTAG00000021455 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1072
CHUKGeneProductENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
CNR1ProteinENSBTAG00000046006 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1268
CREB1ProteinENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CRTC1ProteinENSBTAG00000010379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23373
CSNK2A1ProteinENSBTAG00000012341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1457
CTNNB1ProteinENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
CYFIP1GeneProduct
DAGMetabolite
DLG1ProteinENSBTAG00000020378 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1739
DOCK3ProteinENSBTAG00000001874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1795
DOK5ProteinENSBTAG00000047975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55816
DPYSL2ProteinENSBTAG00000018373 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1808
EEF2ProteinENSBTAG00000004258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1938
EGR1RnaENSBTAG00000010069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1958
EGR2RnaENSBTAG00000046409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1959
EIF2S1ProteinENSBTAG00000016311 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1965
EIF2S2ProteinENSBTAG00000005969 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8894
EIF4EBP1ProteinENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
EIF4EProteinENSBTAG00000009522 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1977
ELK1ProteinENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
FOSRnaENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXO3ProteinENSBTAG00000011234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2309
FRS2ProteinENSBTAG00000019155 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10818
FRS3ProteinENSBTAG00000009861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10817
FYNProteinENSBTAG00000011851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GABRB3ProteinENSBTAG00000013422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2562
GNB2L1ProteinENSBTAG00000019648 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10399
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
GRIA1ProteinENSBTAG00000005800 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2890
GRIA2ProteinENSBTAG00000004775 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2891
GRIA3ProteinENSBTAG00000011833 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2892
GRIN1ProteinENSBTAG00000047202 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2902
GRIN2BProtein
GRIP1ProteinENSBTAG00000033726 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23426
GSK3BProteinENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
HRASProteinENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IGF2BP1ProteinENSBTAG00000011736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10642
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKGGeneProductENSBTAG00000006268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
IP3MetaboliteHMDB01143 (HMDB)
IRS1ProteinENSBTAG00000021308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667
IRS2ProteinENSBTAG00000012019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
JAK2ProteinENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JUNProteinENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KCNA3ProteinENSBTAG00000047879 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3738
KCNN2ProteinENSBTAG00000011076 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3781
KIDINS220ProteinENSBTAG00000007963 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57498
KSR1ProteinENSBTAG00000006601 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8844
LINGO1ProteinENSBTAG00000023147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84894
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K5ProteinENSBTAG00000000218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP3K1ProteinENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K2ProteinENSBTAG00000004216 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10746
MAPK10ProteinENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3ProteinENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK7ProteinENSBTAG00000001014 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MAPK8ProteinENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9ProteinENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MAPTProteinENSBTAG00000017512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4137
MARCKSProtein
MEF2AProteinENSBTAG00000010649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4205
MEF2CProteinENSBTAG00000020701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
MTORProteinENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
NCAM1ProteinENSBTAG00000005710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4684
NCF1ProteinENSBTAG00000003305 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:653361
NCF2ProteinENSBTAG00000008004 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4688
NCK1ProteinENSBTAG00000018427 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4690
NCK2ProteinENSBTAG00000015205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8440
NFATC4ProteinENSBTAG00000006366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4776
NFKB1ProteinENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NGFProteinENSBTAG00000007446 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4803
NGFRProteinENSBTAG00000020979 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4804
NSFProteinENSBTAG00000008442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4905
NTF3ProteinENSBTAG00000010223 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4908
NTRK1ProteinENSBTAG00000003060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4914
NTRK2ProteinENSBTAG00000010647 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4915
NTRK3ProteinENSBTAG00000047543 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4916
PDPK1ProteinENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PIK3CAProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PIP2Metabolite
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCG1ProteinENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
PPP2CAProteinENSBTAG00000000469 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5515
PRKAA1ProteinENSBTAG00000000013 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5562
PRKAA2ProteinENSBTAG00000018747 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5563
PRKCDProteinENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PTK2BProteinENSBTAG00000005958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185
PTPN11ProteinENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
PTPRFProteinENSBTAG00000000253 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5792
RAB3AProteinENSBTAG00000010635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5864
RAC1ProteinENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RANBP9ProteinENSBTAG00000021556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10048
RAP1AProteinENSBTAG00000014710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RASGRF1ProteinENSBTAG00000019940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5923
RELAProteinENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RHOGProteinENSBTAG00000000347 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:391
RPS6ProteinENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KA1ProteinENSBTAG00000014447 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
RPS6KA3ProteinENSBTAG00000017639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6197
RPS6KA5ProteinENSBTAG00000010906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
RPS6KB1ProteinENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
SH2B1ProteinENSBTAG00000019219 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25970
SH2B2ProteinENSBTAG00000009691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10603
SHC1ProteinENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SHC2ProteinENSBTAG00000016072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25759
SHC3ProteinENSBTAG00000011375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53358
SHC4ProteinENSBTAG00000022583 (Ensembl)