SREBF and miR33 in cholesterol and lipid homeostasis (Bos taurus)

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1-9PPARGC1APPARASREBF1SCDHMGCRMTORbta-mir-33aFASNSIRT6SIRT1MED15NR1H3SREBF2bta-mir-33bHMGCS1LDLRABCA1PRKAA1


Description

This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2011(75253) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT; ''Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.''; J Biol Chem, 2010 PubMed
  2. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM; ''Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.''; Genes Dev, 2010 PubMed
  3. Joseph T Rodgers, Pere Puigserver; ''The nuclear hormone receptor LXR—best known for sensing cholesterol metabolites—also responds to glucose. The findings give LXR a central role in modulating the body's response to metabolic inputs.''; Nature Medicine, 2007
  4. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P; ''mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.''; Nature, 2007 PubMed
  5. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T; ''MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.''; Proc Natl Acad Sci U S A, 2010 PubMed
  6. Rodgers JT, Puigserver P; ''Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.''; Proc Natl Acad Sci U S A, 2007 PubMed
  7. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH; ''SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.''; EMBO J, 2007 PubMed
  8. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P; ''Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.''; EMBO J, 2007 PubMed
  9. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM; ''An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.''; Nature, 2006 PubMed

History

CompareRevisionActionTimeUserComment
89948view14:13, 6 October 2016MkutmonModified description
87684view08:55, 25 July 2016LindarieswijkOntology Term : 'homeostasis pathway' added !
80695view15:22, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCA1GeneProductENSBTAG00000020661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
FASNGeneProductENSBTAG00000015980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
HMGCS1GeneProductENSBTAG00000011839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
MED15GeneProductENSBTAG00000018048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
NR1H3GeneProductENSBTAG00000010681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000025434
PPARAGeneProductENSBTAG00000008063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951
PPARGC1AGeneProductENSBTAG00000017024 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109819
PRKAA1GeneProductENSBTAG00000000013 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5562
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319
SIRT1GeneProductENSBTAG00000014023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
SIRT6GeneProductENSBTAG00000019909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077463
SREBF1GeneProductENSBTAG00000007884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
SREBF2GeneProductENSBTAG00000014265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
bta-mir-33aRnaENSBTAG00000029975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932
bta-mir-33bRnaENSBTAG00000036437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839

Annotated Interactions

No annotated interactions
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