SIDS Susceptibility Pathways (Bos taurus)

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7013791239462837626435, 53422610355675784124323, 1245, 89, 114718911739384864111801152414, 74, 9096806360283811512283111563822811928381151059910510910599471051051094110599810912110510916, 9910516, 991092975, 12229105105Putative TRSPhHeartSPhSIDS associated polymorphismsC825TIVS-191_190insArs28569662+TR: Transcriptional RegulationIncreased long-QT with SIDSOtherHNCell MembranePutative TRsPutative TRPutative TRGs signalingFocal AdhesionscircadianSleepSPhG2989TPutative TRsDecreased relative SIDS expression BrownAdiposePutative TRG-proteinNucleusPutative TRsNHGi signalingStabilizationTRrp+Putative TRsSIDS Susceptibility PathwaysPutative TRsSerotonin Synthesis and MetabolismK+SPh2HONucleusCaGq signalingG5477A Slowly-Activating K+ CurrentThermoregulationdepressionSerotoninTransporterSph: SIDS Phenotype Animal ModelAssociated with Infection and SIDSNerve TerminalNa+Associated with Energy Metabolism and SIDSBradycardiaPutative TRCardiac myocyteIncreased brainstem hypoplasia with SIDSPutative TRsPutative TRBrainstem neuronSoma MembraneBrainSerotonin SignalingTRrMiscelaneous SIDS AssociatedVagal ToneK+Increased relative SIDS expressionRapidly-activating K+ Current4R/4RPutative TRInfant (<1 year in age)Sarcoplasmic ReticulumPutative TRs6846811481931418108125115HTR1APPARGC1BDLX2HTR2AFOXM1JUNHES1HES1EN1TNF5-HIAARYR2PHOX2AFEVbta-mir-130aEP300SP3CREB1NGFPBX1ADCYAP1MGC157163MAOASP1HIF1AHSPD1CDCA7Lbta-mir-16aPPARGC1AC4ASSTR2VIPR1AVPKCNH2LMX1BIL10RORANFKB1DEAF1MAZKCNQ1ADCYAP1CREBBPARTPH2bta-mir-210NFKB1ECE1GATA2KCNQ1VIPR2HADHANKX3-1SLC6A45-HTFEVDDCPOU3F2CREB1PKNOX1ADCYAP1R1CREB15-HTCAV3PHOX2BNK1RNEUROD1IL6GR-ABHLHE40ASCL1CHRNA4HES5IL6RSCN5APOU3F2ESR2THRBALDOARUNX3TLX3DDCSP1ACADMGR-ASSTR1TCF3PLP1RYR2TPH1MGC157163YBX1HIF1ATP735-HTPCTCFC4BCXCL85-HTRETMEF2CNicotineEGR1MGC157163MAOAKCNH2CC2D1ANKX2-2SP1CAV3TPH2GATA3MGC157163TPH1L-TryptophanFluoxetineMGC157163NFYAGNB3SP1CHRNB4SP1Glial Cell Differentiation5HTR1A6650408865112345287115678583569811837, 601078549214834289958972752211061Putative TRsCTNNB1SOX2NANOGPOU5F161MAPK pathway99BDNFNTRK2Gi signalingGABAGABRA11973CHRM2GJA110SNTA1Na+H+25K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction120SLC9A3CASP3FMO317G6PCGCK515GPD1LGRIN1HADHB20HTR3ASCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia235-HTGlutamateCa2+43H2OH2OAQP4ApoptosisCPT1A59IL1AIL1B92IL1RN92102IL13101TSPYL1VEGFA116SCN5A54104DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP15Gq signalingMAP-276TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate76SST76TAC1HTR3A79THCHAT13418SLC9A3BDNFNTRK299AQP443GRIN162SP1NFKB244JUNHDAC927MYB91CEBPB94SNTA110GPD1LSP1JUNGR-A84MGC15716397JUNCREB1POU2F2CREM33MGC157163NFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA119CREB130VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs9628