SIDS Susceptibility Pathways (Bos taurus)

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7013791239462837626435, 53422610355675784124323, 1245, 89, 114718911739384864111801152414, 74, 9096806360283811512283111563822811928381151059910510910599471051051094110599810912110510916, 9910516, 991092975, 12229105105NHNucleusSIDS Susceptibility PathwaysThermoregulationOtherSoma MembranePutative TRsSph: SIDS Phenotype Animal ModelTR: Transcriptional RegulationG2989TG-proteinMiscelaneous SIDS AssociatedNa+IVS-191_190insABrainC825TAssociated with Infection and SIDS BrownAdiposeSPhIncreased relative SIDS expressionAssociated with Energy Metabolism and SIDSPutative TRsp+SPhPutative TRsCardiac myocyteNucleusRapidly-activating K+ CurrentBradycardiaInfant (<1 year in age)SleepSPhSerotoninTransporterDecreased relative SIDS expressionStabilizationPutative TR4R/4RFocal AdhesionsK+Putative TRsTRr Slowly-Activating K+ CurrentNerve TerminalCaTRrHNPutative TRPutative TRsPutative TRPutative TRSPhIncreased long-QT with SIDSHOPutative TRPutative TRsVagal ToneG5477APutative TRSerotonin SignalingGi signalingSarcoplasmic ReticulumcircadianSIDS associated polymorphismsrs2856966depressionHeartBrainstem neuronSerotonin Synthesis and MetabolismGq signalingK+Cell MembraneIncreased brainstem hypoplasia with SIDSGs signaling2+Putative TRPutative TRs2684681148193141810812511GATA3TNFTCF35-HTCREB1CXCL8MAOACREBBPTLX3DDCSLC6A4VIPR1HTR2AMGC157163PBX1KCNQ1MEF2CSP3bta-mir-130aPKNOX15-HTADCYAP15-HTTP73NK1RALDOAGR-AKCNH2JUNCDCA7LSSTR1HES1RORAGNB3SP1KCNQ1SCN5AADCYAP1MGC157163NicotineC4APPARGC1BNGFYBX15HTR1AGR-Abta-mir-210RETTPH25-HIAANKX3-1ESR2C4BNFYASP1HSPD1CAV3MGC157163TPH1SP1CC2D1ARUNX3IL6RMAOAGATA2SSTR2HES1AVPNEUROD1MGC157163HES5FEVRYR2IL6KCNH2LMX1BEN1HIF1AGlial Cell DifferentiationDLX2ECE1FEVSP1HADHAL-TryptophanFluoxetineBHLHE40THRBDEAF1CAV3CHRNA4CREB1HIF1AMGC1571635-HTPDDCACADMCHRNB4PHOX2AMAZCTCFSP1EGR1IL10ASCL1RYR2ARADCYAP1R1TPH2NFKB1PHOX2BFOXM1NFKB1NKX2-2POU3F2bta-mir-16a5HTR1APPARGC1AEP300VIPR2TPH1CREB1PLP1POU3F26650408865112345287115678583569811837, 601078549214834289958972752211061Putative TRsCTNNB1SOX2NANOGPOU5F161MAPK pathway99BDNFNTRK2Gi signalingGABAGABRA11973CHRM2GJA110SNTA1Na+H+25K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction120SLC9A3CASP3FMO317G6PC51GCKGPD1L5GRIN1HADHB20HTR3ASCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia235-HTGlutamateCa2+43H2OH2OAQP4ApoptosisCPT1A59IL1A92IL1BIL1RN92102IL13101TSPYL1VEGFA11654SCN5A104DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP15Gq signalingMAP-2TAC176MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate76SSTTAC176HTR3ATH7913CHAT418SLC9A3BDNFNTRK299AQP443GRIN162SP144NFKB2JUN27HDAC9MYB91CEBPB94SNTA110GPD1LSP1JUNGR-AMGC1571638497JUNCREB1POU2F2CREM33MGC157163NFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA119CREB130VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs9628