Bladder Cancer (Bos taurus)

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33333332333333333Reduced expressionDegradation of extracellular matrixEndothelial cell migrationOxidative stressChemoattraction of endothelial cellsEndothelial Cell proliferationG1/S ProgressionDefect in cell-cell adhesionUrothelial cellNormal urotheliumDNAPromoter methylationCXCL8EGFMAPK Signaling PathwayRB1MAPK1VEGF Signaling PathwayCCND1VEGFACell CycleTYMPCDKN1AMMP1ErbB Signaling PathwayDAPK2Adherens junctionFGFR3ERBB2DAPK1PI3KMYCHRASp85-BetaRPS6KA5TP53MAP2K1RASSF1MDM2p53 signaling pathwayCDKN2AEGFRE-CADHERINCDKN2AHRASTHBS1AngiogenesisE2F1DAPK3PIK3R1BRAFPPP4MAP2K21PCDK4NucleusDNADNADNADNADNAHyperplasiaLow-gradenon-invasivepapillary tumourRecurrenceInvasive tumour(High-grade)MetastasisCIS / DysplasiaNormal urothelium


Description

The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF). Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway+map05219

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2828(79529) with a 88.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Wolf EM, Liang G, Jones PA; ''Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.''; http://www.ncbi.nlm.nih.gov/pubmed/16474624, 2005 PubMed Europe PMC
  2. Calderaro J, Rebouissou S, de Koning L, Masmoudi A, Hأ©rault A, Dubois T, Maille P, Soyeux P, Sibony M, de la Taille A, Vordos D, Lebret T, Radvanyi F, Allory Y; ''PI3K/AKT pathway activation in bladder carcinogenesis.''; Int J Cancer, 2014 PubMed Europe PMC
  3. ''Bladder Cancer Pathway''; http://www.genome.jp/dbget-bin/www_bget?pathway+map05219,
  4. Juanpere N, Agell L, Lorenzo M, de Muga S, Lأ³pez-Vilarأ³ L, Murillo R, Mojal S, Serrano S, Lorente JA, Lloreta J, Hernأ،ndez S; ''Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer.''; Hum Pathol, 2012 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
89145view21:56, 22 August 2016AriuttaOntology Term : 'cancer pathway' added !
89144view21:56, 22 August 2016AriuttaOntology Term : 'disease pathway' added !
87361view09:40, 22 July 2016MaintBotadded missing graphids
80685view15:22, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Adherens junction Pathway
AngiogenesisPathwayWP1539 (WikiPathways)
BRAFGeneProductENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
CXCL8GeneProductENSBTAG00000019716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3576
Cell Cycle PathwayWP179 (WikiPathways)
DAPK1GeneProductENSBTAG00000000738 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1612
DAPK2GeneProductENSBTAG00000011820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23604
DAPK3GeneProductENSBTAG00000020417 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1613
E-CADHERINGeneProductENSBTAG00000015991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
EGFGeneProduct
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
ERBB2GeneProductENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
ErbB Signaling PathwayPathwayWp673 (WikiPathways)
FGFR3GeneProductENSBTAG00000007164 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000068078
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MMP1GeneProductENSBTAG00000048029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4312
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
PI3KProtein
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
RASSF1GeneProductENSBTAG00000020963 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11186
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
THBS1GeneProductENSBTAG00000002006 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
TYMPGeneProduct
VEGF Signaling PathwayPathwayWP1919 (WikiPathways)
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
p53 signaling pathwayPathwayWP1742 (WikiPathways)
p85-BetaGeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;

Annotated Interactions

No annotated interactions
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