Cardiac Progenitor Differentiation (Bos taurus)

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1, 2ES/IPS cellsHypoxiaPOU5F1INSRetinoic acidNANOGSOX2LIN28ALIN28BZFP42THY1EctodermSOX1PAX6EndodermSOX17FOXA2MesodermMesodermProgenitorNCAM1TANPEPMIXL1ROR2WNT3ABMP4INHBAGSK3BFGF2Day 1Day 2CardiacMesodermMESP1MESP2KDRKITDay 3-4CXCR4PDGFRANOTCH1CardiacProgenitorISL1NKX2-5GATA4TBX5Day 5-6TBX20MEF2CMAPK14BMP1NOGNODALTGFB1WNTDKK1ImmatureCardiomyocyteMYH7TNNT2TNNI3MYLK3Day 7SIRPB1MEF2CMatureCardiomyocyteTNNT2ACTC1MYL2SCN5ADay 30+IRX4IGF2IGF-IWNT3AGGFBPP5


Description

Factors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2406(73324) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Stillitano F, Karakikes I, Fish KD, Hajjar RJ, Hulot S; ''Preclinical animal models for testing iPSC/ESC-based heart therapy''; , 2012
  2. Burridge PW, Keller G, Gold JD, Wu JC; ''Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.''; Cell Stem Cell, 2012 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
106008view11:53, 16 August 2019MaintBotHMDB identifier normalization
89249view05:27, 26 August 2016KhanspersOntology Term : 'regular cardiac myocyte' added !
89158view03:17, 23 August 2016AriuttaOntology Term : 'regulatory pathway' added !
80682view15:21, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTC1GeneProductENSBTAG00000005714 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159251
ANPEPGeneProductENSBTAG00000016881 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166825
BMP1GeneProductENSBTAG00000000917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168487
BMP4GeneProductENSBTAG00000003835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
CXCR4GeneProductENSBTAG00000001060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121966
DKK1GeneProductENSBTAG00000014218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984
FGF2GeneProductENSBTAG00000005691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
FOXA2GeneProductENSBTAG00000012407 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125798
GATA4GeneProductENSBTAG00000005425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136574
GGFBPP5GeneProductENSBTAG00000004150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157168
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000082701
IGF-IGeneProductENSBTAG00000011082 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427
IGF2GeneProductENSBTAG00000013066 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167244
INHBAGeneProductENSBTAG00000002912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122641
INSGeneProduct
IRX4GeneProductENSBTAG00000015907 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113430
ISL1GeneProductENSBTAG00000001241 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000016082
KDRGeneProductENSBTAG00000000782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128052
KITGeneProductENSBTAG00000002699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157404
LIN28AGeneProductENSBTAG00000048256 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131914
LIN28BGeneProductENSBTAG00000043973 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187772
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112062
MEF2CGeneProductENSBTAG00000020701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081189
MESP1GeneProduct
MESP2GeneProductENSBTAG00000027058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000188095
MIXL1GeneProductENSBTAG00000002139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185155
MYH7GeneProductENSBTAG00000040053 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197616
MYL2GeneProductENSBTAG00000018369 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111245
MYLK3GeneProductENSBTAG00000014818 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140795
NANOGGeneProductENSBTAG00000020916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111704
NCAM1GeneProductENSBTAG00000005710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149294
NKX2-5GeneProductENSBTAG00000020568 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183072
NODALGeneProductENSBTAG00000013090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574
NOGGeneProductENSBTAG00000040282 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691
NOTCH1GeneProductENSBTAG00000022799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
PAX6GeneProductENSBTAG00000004561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007372
PDGFRAGeneProductENSBTAG00000007173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134853
POU5F1GeneProductENSBTAG00000001873 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204531
ROR2GeneProductENSBTAG00000005092 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169071
Retinoic acidMetaboliteHMDB01852 (HMDB)
SCN5AGeneProductENSBTAG00000009155 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183873
SIRPB1GeneProductENSBTAG00000039520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198053
SOX17GeneProductENSBTAG00000005748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164736
SOX1GeneProductENSBTAG00000038272 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182968
SOX2GeneProductENSBTAG00000011598 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
TBX20GeneProductENSBTAG00000017541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164532
TBX5GeneProductENSBTAG00000011384 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089225
TGeneProductENSBTAG00000018681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164458
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
THY1GeneProductENSBTAG00000019627 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154096
TNNI3GeneProductENSBTAG00000006424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129991
TNNT2GeneProductENSBTAG00000045789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118194
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342
WNTPathwayWP399 (WikiPathways)
ZFP42GeneProductENSBTAG00000044139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179059

Annotated Interactions

No annotated interactions
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