DNA Damage Response (Bos taurus)

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1597731, 2, 5, 12-14, 17...73, 163, 16183881, 2, 5, 12-14, 17...73, 1678971, 2, 5, 12-14, 17...91677715773, 161, 2, 5, 12-14, 17...1, 2, 5, 12-14, 17...1, 2, 5, 12-14, 17...71, 2, 5, 12-14, 17...3, 161531, 4, 6, 10, 1178Extral cellularSpaceSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingROSDNA damage sourceChromatinremodellingG2/M transitionBulky DNA lesionG2/M checkpointDouble-strand breaksEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)InhibitionDifferent pathwayROSG1/S transitionCell survivalBlocked transcriptionChromatin alterationCaptionCellDNA repairDNA damage ATM dependentExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsReplication stressActivationDNA adductCell-cycle progressionBlocked replicationmitoch-ondrionMembraneGene productG2âˆڑأ‰آ¬آ¢âˆڑأ‡آ¬أ„âˆڑأ‡آ¬أ¬MCheckpointMetaboliteChange in the Cell conditionDNA repair and damage preventionAlkylating agentsRAD51MYCGADD45AAPAF1CCND3Cell CycleCDKN1AHUS1TNFRSF10DCCNB2CDC25CGADD45GMRE11AGADD45GSFNSenescenceRRM2BCCND2CASP9H2AFXCCND17-hydroxystaurosporinePIDD1BAXGADD45ARFC1CDK6BBC3TLK2CCNB3PMLCHEK2FANCD2RB1CDC25AABL1ATMCASP3BID2RAD9ACCNE2CDK1CHEK1NBNRAD50ApoptosisATRIPRB1SMC1AEstradiolRAD1CREB1MDM2FASGADD45BGADD45BATRRAD17RPA2PRKDCCYCSCDK4CaffeineTP53AIP1E2F1E2F1CDK2TP53RAD52TLK1SESN1DDB2PMAIP1CCNE1CCNB1CDK5CDKN1BBRCA1CASP8


Description

This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.

If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP707(79975) with a 94.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC
  2. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC
  3. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC
  4. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC
  5. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC
  6. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC
  7. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnâˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أ©âˆڑأ‡آ¬آ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC
  8. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC
  9. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC
  10. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC
  11. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC
  12. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC
  13. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC
  14. Lâˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أ©âˆڑأ‡آ¬آ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC
  15. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC
  16. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC
  17. Toledo F, Wahl GM; ''Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.''; Nat Rev Cancer, 2006 PubMed Europe PMC
  18. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U; ''Dynamics of the p53-Mdm2 feedback loop in individual cells.''; Nat Genet, 2004 PubMed Europe PMC
  19. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
107059view14:14, 17 September 2019MaintBotChEBI identifier normalization
80664view15:21, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000097007
APAF1GeneProductENSBTAG00000021661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120868
ATMGeneProductENSBTAG00000003111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149311
ATRGeneProductENSBTAG00000011529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175054
ATRIPGeneProductENSBTAG00000008399 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84126
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSBTAG00000013340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087088
BBC3GeneProduct
BID2GeneProductENSBTAG00000013988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000015475
BRCA1GeneProductENSBTAG00000022520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000012048
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064012
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132906
CCNB1GeneProductENSBTAG00000014239 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134057
CCNB2GeneProductENSBTAG00000005269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157456
CCNB3GeneProductENSBTAG00000046286 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147082
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110092
CCND2GeneProductENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118971
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112576
CCNE1GeneProductENSBTAG00000004735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105173
CCNE2GeneProductENSBTAG00000004906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175305
CDC25AGeneProductENSBTAG00000009586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164045
CDC25CGeneProductENSBTAG00000005293 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158402
CDK1GeneProductENSBTAG00000010109 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170312
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123374
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135446
CDK5GeneProductENSBTAG00000007766 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164885
CDK6GeneProductENSBTAG00000044023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105810
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124762
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111276
CHEK1GeneProductENSBTAG00000017582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149554
CHEK2GeneProductENSBTAG00000004956 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183765
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CYCSGeneProductENSBTAG00000022613 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172115
CaffeineMetabolite2424 (Chemspider)
Cell CyclePathwayWP179 (WikiPathways)
DDB2GeneProductENSBTAG00000020999 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134574
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101412
EstradiolMetaboliteCHEBI:16469 (ChEBI)
FANCD2GeneProductENSBTAG00000010077 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000144554
FASGeneProductENSBTAG00000010785 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000026103
GADD45AGeneProductENSBTAG00000013860 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116717
GADD45BGeneProductENSBTAG00000025462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099860
GADD45GGeneProductENSBTAG00000003033 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130222
H2AFXGeneProductENSBTAG00000038047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000188486
HUS1GeneProduct
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135679
MRE11AGeneProductENSBTAG00000008925 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4361
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NBNGeneProductENSBTAG00000013225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4683
PIDD1GeneProductENSBTAG00000019634 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55367
PMAIP1GeneProduct
PMLGeneProductENSBTAG00000015779 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140464
PRKDCGeneProductENSBTAG00000017019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729
RAD17GeneProductENSBTAG00000002073 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152942
RAD1GeneProductENSBTAG00000019209 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113456
RAD50GeneProductENSBTAG00000011252 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113522
RAD51GeneProductENSBTAG00000002918 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000051180
RAD52GeneProductENSBTAG00000005225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000002016
RAD9AGeneProductENSBTAG00000012141 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172613
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139687
RFC1GeneProductENSBTAG00000014515 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5981
RPA2GeneProductENSBTAG00000006225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117748
RRM2BGeneProductENSBTAG00000021208 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000048392
SESN1GeneProductENSBTAG00000003015 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080546
SFNGeneProductENSBTAG00000009223 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175793
SMC1AGeneProductENSBTAG00000017761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072501
SenescencePathwayWP615 (WikiPathways)
TLK1GeneProductENSBTAG00000006918 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198586
TLK2GeneProductENSBTAG00000015713 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146872
TNFRSF10DGeneProductENSBTAG00000047389 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120889
TP53AIP1GeneProduct
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510

Annotated Interactions

No annotated interactions
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