Interactome of polycomb repressive complex 2 (PRC2) (Homo sapiens)

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2LegendPRC2Interaction identified by multiple replicatesMTF2ELLJMJTRIM35STK38THRAP3BCLAF1STK38SETXMORC31Interaction identified by few replicatesPreviously identified interactionRBBP7AEBP2EZH2EEDSUZ12EZH1RBBP4


A proposed interactome of Polycomb repressive complex 2 (PRC2), based on proteomics. PRC2 has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27, a mark of transcriptionally silent chromatin, and is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced. Based on figure 1B in Shen et al.

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Ontology Terms



  1. Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND; ''Regulation of cyclin D1 RNA stability by SNIP1.''; Cancer Res, 2008 PubMed Europe PMC Scholia
  2. Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH; ''Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.''; Cell, 2009 PubMed Europe PMC Scholia


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104425view17:56, 24 May 2019Khanspersupdated legend
104424view17:54, 24 May 2019KhanspersModified description
88672view15:36, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
87379view11:05, 22 July 2016MaintBotadded missing graphids
79908view21:10, 24 April 2015KhanspersModified description
79907view21:03, 24 April 2015KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
AEBP2GeneProductENSG00000139154 (Ensembl)
BCLAF1GeneProductENSG00000029363 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
ELLGeneProductENSG00000105656 (Ensembl)
EZH1GeneProductENSG00000108799 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
JMJGeneProductENSG00000008083 (Ensembl)
MORC3GeneProductENSG00000159256 (Ensembl)
MTF2GeneProductENSG00000143033 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RBBP7GeneProductENSG00000102054 (Ensembl)
SETXGeneProductENSG00000107290 (Ensembl)
STK38GeneProductENSG00000112079 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
THRAP3GeneProductENSG00000054118 (Ensembl)
TRIM35GeneProductENSG00000104228 (Ensembl)

Annotated Interactions

No annotated interactions

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