Differentiation of white and brown adipocyte (Homo sapiens)

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1, 211White AdipocytePRDM16BMP4Smad9PGC-1βEVA1Smad1Smad5ASC-1C/EBPδHOXC9CIDEAPPARγPGC-1αHOXC8C/EBPαZIC1LeptinAdiponectinEBF3Smad8BMP2PRDM16BMP7C/EBPβZfp423PRDM16HSPB7PLAC8Brown AdipocytePreadipocyteVascular progenitorsSmad5Smad1C/EBPβ


Description

Development of white versus brown adipocytes (figure from Handbook of Obesity). Transcription factors and nuclear regulators controlling the development of white versus brown adipocytes are shown in the pathway. At the bottom a selection of identified markers of white and brown adipocytes were added (from Nascimento et al).

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Ontology Terms

 

Bibliography

  1. Nascimento EB, Boon MR, van Marken Lichtenbelt WD; ''Fat cells gain new identities.''; Sci Transl Med, 2014 PubMed
  2. George A. Bray, Claude Bouchard; ''Handbook of Obesity (3rd edition)''; CRC Press, 2014

History

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CompareRevisionActionTimeUserComment
87889view12:47, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
79216view10:41, 13 March 2015EgonwAdded GraphId's to a number of DataNode's which didn't have one.
78904view15:40, 11 February 2015MkutmonModified description
78903view15:39, 11 February 2015MkutmonModified description
78902view15:38, 11 February 2015MkutmonModified description
78901view15:27, 11 February 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASC-1GeneProductENSG00000130876 (Ensembl)
AdiponectinGeneProductENSG00000181092 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
C/EBPαGeneProductENSG00000245848 (Ensembl)
C/EBPβGeneProductENSG00000172216 (Ensembl)
C/EBPδGeneProductENSG00000153879 (Ensembl)
CIDEAGeneProductENSG00000176194 (Ensembl)
EBF3GeneProductENSG00000108001 (Ensembl)
EVA1GeneProductENSG00000149573 (Ensembl)
HOXC8GeneProductENSG00000037965 (Ensembl)
HOXC9GeneProductENSG00000180806 (Ensembl)
HSPB7GeneProductENSG00000173641 (Ensembl)
LeptinGeneProductENSG00000174697 (Ensembl)
PGC-1αGeneProductENSG00000109819 (Ensembl)
PGC-1βGeneProductENSG00000155846 (Ensembl)
PLAC8GeneProductENSG00000145287 (Ensembl)
PPARγGeneProductENSG00000132170 (Ensembl)
PRDM16GeneProductENSG00000142611 (Ensembl)
Smad1GeneProductENSG00000170365 (Ensembl)
Smad5GeneProductENSG00000113658 (Ensembl)
Smad8GeneProductENSG00000120693 (Ensembl)
Smad9GeneProductENSG00000120693 (Ensembl)
ZIC1GeneProductENSG00000152977 (Ensembl)
Zfp423GeneProductENSG00000102935 (Ensembl)

Annotated Interactions

No annotated interactions

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