Nuclear Receptors Meta-Pathway (Homo sapiens)

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10, 48CAR/PXR LigandOtherOtherCAR target genesOtherOtherOther1791750SULT2A1TGFB2GSTA3STOMSMC1AGSTT1SERPINB2CYP3A4UGT1A3ETNK2DNAJC7CYP4A11NCOA6UGT1A4UGT1A7SPINK13SULT2A1NCOA2FGFBP1HGFSLC2A7IL17BGSRSP1GPR153ALAS1SLC27A5PPARACES2CYP1B1GSTA2Co-activatorsSLC2A13CYP4A11CDC42EP3CYP2A6HSP90AB1GPAMPRRG4UGT1A4CDKN1CUGT1A6NR1H3ENC1Cell proliferationand apoptosisBIRC3EPB41L4BUGT1A1ALOX5APSEC14L1GCLMCBR3UGT1A9TSC22D3UGT1A9TGFB1SLC2A4MYOFMGST1FTLAntioxidantproteinsFTH1UGT2B4ABCB1FASNRGS2B3GNT5CYP1A2CES3FGD4NR3C1DNERMAFFCES5ANRG1NQO1NR0B2TGFB1FGF13SDPRIRS2EDN2SLC2A6AKAP13POU5F1NR0B2ABCC5PRDX6TNFAIP3ABCC2SPRY1HSPA1AKEAP1IP6K3TGFBR2BLVRBSERTAD2CYP2C9CAP2BIRC2POLKCYP2B6SLC10A1GPX2MGST3CYP3A4PDE4BGSTA1TGFAInflammationPPARGC1AGCLCUGT1A6ABCB11TranscriptionfactorsHMOX1KTN1CYP1A1SLC19A2JUNBIFNGEHHADHSTAT3MAFGSLC2A5RXRACYP2A6EPHA2UGT2B7SLCO2B1PTGR1CYP8B1CES4ASERPINB9TGFBR3SULT2A1ARL5BCYP7A1SRXN1PPP1R14CDrug and steroidmetabolismCCL2ABCC3IL11SP1JUNFGF19SLC2A3UGT1A3GSTT2PGDCYP7A1PMP2CES1bile acidconjugationABCB4PRDX1GSTA4NR1I3CBR1EGR1Bile acidneosynthesisSRCSLC2A1Phase 2metabolismSLC2A10CUL1SOD3AMIGO2ANGPTL4NR1H4CYP2A6CPEB4ABCC4NR0B2GGT1KAT2BPCK1NCOA1SRGNABCC2GADD45BCYP2B6TXNRD3PPARGC1ATXNBile acid &xenobiotics transportDNAJC15IL1BZIC2PDGFBSLC26A2MGAMABCG8S100PSERPINA1PLK2CYP3A4ACAA1UGT1A1ALDH3A1CYP3A5PDK4ABHD2SMARCA1EP300SLC2A8ADH7BHLHE40CXCR7EPHA3SNAI2LRRC8ASLC7A5G6PDUGT1A3SLC2A14ANKRD1SCNN1AESR1GSTP1IL12BFKBP5MFGE8GPX3CYP7A1ME1NFKB2Cell proliferationand differentiationMetabolismPPP2R4NFE2L2JUNUGT1A4SLC2A9DNAJB1UGT1A9CYP2C19CCL20TNS4GPR115CYP3A7SREBF1NAV3GSTA2THBDHBEGFPTGS2SQSTM1HSP90AA1CES3MT1IPBAATACOX1SLC2A12HSP90AA1MGST2UGT1A7SLC2A11ABCC3AGERSLC2A2ABCG5GCC1PPARDPPARASLC7A11TranscriptionfactorsSULT1A1TXNRD1IL12AGSTA516164512122520372912144121612130131NR1I316123538381144125127124512314412387474219441220129244629127445934116121633124116328, 4912145293938LigandDNAJC7HSP90AA1CoregulatorsGenesTATA boxPBREMRXRANR1I3LigandCo-activatorsNCOA1EGFR pathwayEP300UGT1A6AHRR12, 16, 40SRC44CDKN1B44AIPCYP1B116, 20, 40, 44, 45UGT1A1ALDH3A112, 16, 4045GSTA216, 40AHRJUND13NQO116, 40IGFBP1NFE2L215BAX4044JUN4CYP1A2EGFR16, 20, 40, 44, 45HSP90AA1TNFPTGES3IL251HES1ARNT8CDC37CYP1A1AHR16, 20, 40, 44, 45ARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxUGT1A9Hepatocyteproliferation11, 12NR1H311SCP211CPT1AAPOC31111FABP1CCND111PLTP11DBI11APOA211CPT21111APOA111CYP4A1111ACADM11CDK4CYP7A11111MYCmitochondrialomega-oxidation11SLC27A1Cholesterolcatabolism11peroxisomalbeta-oxidationKLK1511APOA511CDK111CYP8B111PPAR alpha ligandPPARAGenesTATA boxPPREPPARARXRALigandlipoproteinmetabolismfatty acidtransportmitochondrialbeta-oxidationPXR target genes14, 38SLCO1B1HSP90AA114NR1I2SRPX2NCOA3FOXO1CYP4F1232CYP3A414UGT1A116DNAJC714ABCC4NRIP114UnknownCYP2B616GSTA2PSMC514PPARGC1ANCOA1NCOA2ABCB1NR1I214LigandCoregulatorsGenesTATA boxXRERXRANR1I2LigandAhR LigandCo-activatorsGenesTATA boxNR1I3NR1I2NR3C1RXRA28, 49NR1I3NR1I2NR3C1HSP90AA1GR ligandp23HSP90AA1p23NR3C1HSP90AA118, 42p23NR3C1Ligand42NR3C1Ligand42LigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGRECoregulatorsGR inhibitorytarget genesLXR ligandNR1H3LigandRXRA28, 49PTGES3RXRA28, 49NR1H3CYP2B6CYP2C911GenesTATA boxVDREVDR target genes23, 42VDRLigandRXRACYP3A41VDRVDR ligandRXRAVDRLigandER ligandESR1ESR1LigandLigandGenesTATA boxEREESR1LigandESR1LigandESR139ESR1ESR1LigandLigandCoregulatorsER target genes25GenesTATA boxNR1H3LigandLXRERXRA28, 49LXR target genesFXR ligandNR1H4RXRA33LigandGenesTATA boxNR1H4RXRA33LigandFXREBile aciddetoxification5NR1H433LigandUGT1A412UGT1A612UGT1A912UGT1A3CYP2C912CYP3A51616CYP2C19SULT2A11631ABCC21ABCC31EHHADH29FOXO132InflammationGrowth andapoptosis1717Signaltransduction17InflammationGrowth andapoptosis1717Signaltransduction17MetabolismTransport1717NuclearreceptorsFXR Target genesGR stimulatorytarget genesMulti-drugresistanceDrug and steroidmetabolismPhase 2metabolismMulti-drugresistancePhase 2metabolismDrug and steroidmetabolismPhase 2metabolismDrug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsDrug and steroidmetabolismTranscriptionfactorsDrug and steroidmetabolismPPAR alphatarget genesAhR target genesGenesTATA boxRXRALigandARENRF2 targetgenesPhase 1proteins9Phase 2proteinsGSTM59GSTM1GSTM2GSTM3GSTM4Transport9SLC5A2SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14Growth factorsand receptors9NFE2L2NRF2 ligandKEAP1NFE2L2LigandNFE2L2NFE2L2SCDOtherOtherOtherOtherOther