Estrogen Receptor Pathway (Homo sapiens)

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46MetabolismTranscription factorsDrug and steroid metabolismCell proliferation and apoptosisLigandEstrogenSP1ESR1JUN10ESR1ESR1EREESR1ESR1ESR1ESR110ESR1LigandLigandCoregulatorsPDK4STAT3ACOX1GPAMPCK1CYP1A1PPARACYP1A2NR0B2CYP1B1LigandLigandLigand


Description

The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian). Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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History

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CompareRevisionActionTimeUserComment
106406view21:34, 28 August 2019KhanspersModified description
105586view04:43, 10 August 2019KhanspersModified description
94937view16:36, 15 October 2017Khanspersadded ligand and updated transctiption
94788view22:57, 5 October 2017AlexanderPicoConverted lines and compacted layout
94786view22:46, 5 October 2017AlexanderPicoConverted lines and compacted layout
88032view13:34, 25 July 2016SusanOntology Term : 'estrogen signaling pathway' added !
88030view13:34, 25 July 2016SusanOntology Term : 'PW:0001303' removed !
88029view13:33, 25 July 2016SusanOntology Term : 'steroid metabolic pathway' added !
79603view06:03, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79557view13:13, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79519view09:39, 24 March 2015Riannefijtenadded reference
79517view09:33, 24 March 2015Riannefijtensolved unconnected lines
79492view13:35, 23 March 2015RiannefijtenModified description
79491view13:31, 23 March 2015Riannefijtenconnected unconnected lines and changed function groups to labels instead of pathway boxes
78550view10:30, 7 January 2015MaintBotadded missing graphIds
78259view22:24, 17 December 2014KhanspersModified title
78228view15:35, 14 December 2014MaintBotUpdated the GPML schema.
78223view15:26, 14 December 2014MaintBotModified title
78094view11:38, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACOX1GeneProductENSG00000161533 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
ESR1GeneProductENSG00000091831 (Ensembl)
EstrogenMetaboliteCHEBI:4903 (ChEBI)
GPAMGeneProductENSG00000119927 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LigandMetaboliteCHEBI:48705 (ChEBI)
NR0B2GeneProductENSG00000131910 (Ensembl)
PCK1GeneProductENSG00000124253 (Ensembl)
PDK4GeneProductENSG00000004799 (Ensembl)
PPARAGeneProductENSG00000186951 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)

Annotated Interactions

No annotated interactions

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